Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom

Rayman, Margaret P.; Bode, P.; Redman, Christopher W.G.

doi:10.1067/s0002-9378(03)00723-3

Cited by 138 publications

(103 citation statements)

References 22 publications

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“…In animal models selenium deficiency is associated with infertility and miscarriage, and selenium supplementation in sheep has been shown to prevent early miscarriage [42]. In humans, low levels of selenium have been shown to be associated with miscarriage [43], recurrent miscarriage in particular [44] and pre-eclampsia [45]. Previous studies have demonstrated an important role for GSHPx activity in human follicular fluid.…”

Section: Discussionmentioning

confidence: 99%

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Dickerson¹,

Sathyapalan

Knight

et al. 2011

J Assist Reprod Genet

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Purpose There is increasing concern that environmental chemicals have a direct effect on fertility. Heavy metals such as mercury have been shown to affect various organ systems in humans including nervous system and skin, however they could also act as endocrine disrupting chemicals adversely affecting fertility. Metals such as zinc and selenium are essential micronutrients with diverse functions that may be important for reproductive outcomes. We measured mercury, zinc and selenium levels in the hair, a reliable reflection of long term environmental exposure and dietary status, to correlate with the outcome of ovarian hyperstimulation for in vitro fertilisation (IVF) treatment. Methods We analysed the hair of 30 subfertile women for mercury, zinc and selenium using inductively coupled mass spectrometry. Each woman underwent one cycle of IVF treatment. Correlation between the levels of these trace metals and treatment outcomes was investigated.Results Thirty women were recruited with mean (±SD) age of 32.7(4.4) years and BMI of 25.4(5.0)kg/m 2 . Hair mercury concentration showed a negative correlation with oocyte yield (p<0.05,βcoefficient 0.38) and follicle number (p=0.03,β coefficient0.19) after ovarian stimulation. Zinc and selenium levels in hair correlated positively with oocyte yield after ovarian stimulation (p<0.05,β coefficient0.15) and (p=0.03,β coefficient0.21) respectively. Selenium levels in hair correlated significantly with follicle number following stimulation (p=0.04, βcoefficient0.22). There was no correlation between mercury, zinc and selenium in hair and their corresponding serum levels. Conclusion These data suggest that mercury had a deleterious effect whilst there was a positive effect for zinc and selenium in the ovarian response to gonadotrophin therapy for IVF. Hair analysis offers a novel method of investigating the impact of long-term exposure to endocrine disruptors and nutritional status on reproductive outcomes. Keywords IVF . Heavy metals . Endocrine disruptorsSubfertility affects approximately 1 in 6 couples in the developed world [1], a prevalence that is likely to increase as more women delay childbirth to a later age [2]; approximately 28% of couples investigated for subfertility have a diagnosis of 'unexplained subfertility' [3]. Current treatment largely consists of assisted reproductive techniques (ART) such as IVF or IVF-ICSI, often regardless of the underlying cause. The average success rate of 25-30% for ART in Europe remains unchanged over recent years [4], prompting the search for additional factors which may influence fertility treatments and optimise success, and the identification of adverse factors such as endocrine disrupting chemicals.Capsule Mercury concentration in hair had a deleterious effect where as zinc and selenium had a beneficial effect in ovarian response to gonadotrophin therapy for IVF.

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Section: Discussionmentioning

confidence: 99%

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Dickerson¹,

Sathyapalan

Knight

et al. 2011

J Assist Reprod Genet

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“…The selenoproteins phospholipid GPx4 and sperm nuclei selenoprotein are required for sperm motility and sperm maturation, while selenoprotein-P is required for Se supply to the testes Summarised in Rayman (9) Sufficiency of Se intake improves male fertility, reduces the risk of miscarriage and may reduce the risk of pre-eclampsia Summarised in Rayman (9) , Rayman et al (73) Immune function Randomised placebo-controlled trials show that Se supplementation of UK adults enhances the cellular response, while supplementation of elderly Belgians restores the age-related decline in immune response Broome et al (74) , Peretz et al (75) Mortality A 12-year follow-up of 13 887 adult participants in the US NHANES III whose serum Se was measured at baseline shows that increasing Se is associated with decreased mortality up to a serum concentration of 130 mg/l Bleys et al (76) A study of 1389 elderly French subjects suggests that low plasma Se concentration at baseline is significantly associated with higher mortality over 9 years…”

Section: Antiviral Effects and Hivmentioning

confidence: 99%

Symposium on ‘Geographical and geological influences on nutrition’ Factors controlling the distribution of selenium in the environment and their impact on health and nutrition

2009

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Se is essential to human and animal health but can be toxic in excess. An interest in its geochemistry has developed alongside a greater understanding of its function in a number of health conditions. Geology exerts a strong control on the Se status of the surface environment; low-Se rock-types (0·05–0·09 mg Se/kg) make up the majority of rocks occurring at the Earth's surface, which in turn account for the generally low levels of Se in most soils. However, there are exceptions such as associations with sulfide mineralisation and in some types of sedimentary rocks (e.g. black shales) in which contents of Se can be much higher. Baseline geochemical data now enable a comparison to be made between environmental and human Se status, although a direct link is only likely to be seen if the population is dependent on the local environment for sustenance. This situation is demonstrated with an example from the work of the British Geological Survey in the Se-deficiency belt of China. The recent fall in the daily dietary Se intake in the UK is discussed in the context of human Se status and declining use of North American wheat in bread making. Generally, US wheat has ten times more Se than UK wheat, attributed to the fact that soils from the wheat-growing belt of America are more enriched in Se to a similar order of magnitude. In agriculture effective biofortification of crops with Se-rich fertilisers must be demonstrably safe to the environment and monitored appropriately and baseline geochemical data will enable this process to be done with confidence.

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“…It is therefore of some interest that a poor maternal selenium (Se) status may be a predictor of preeclampsia, given that women who develop overt preeclampsia have a lower Se status. 78 Vanderlelie et al 79 studied the tissue levels of endogenous antioxidant proteins (SOD, GHS peroxidase, thioredoxin reductase and thioredoxin) and of lipid and protein oxidation in placental samples from normal and preeclamptic pregnancies and found a decreased enzymatic antioxidant capacity in placental tissue from preeclamptic women compared to controls. Highly significant reductions in serum Se concentrations and plasma GSH peroxidase activity were found in pregnancy per se compared to non-pregnant subjects.…”

Section: Role Of Antioxidants In Preeclampsiamentioning

confidence: 99%

Micronutrients in pregnancy: Current knowledge and unresolved questions

et al. 2011

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One-carbon metabolism Pregnancy Liposoluble vitamins Minerals s u m m a r yMicronutrient status is increasingly recognized to play an important role in the health and well-being of pregnant women and in the development and long-term health of the offspring. On 26th e 28th February 2009, The Child Health Foundation invited leading experts in this area to a scientific workshop at Obergurgl, Austria to review and critically discuss current knowledge, to identify issues that may need to be addressed in future recommendations, and to highlight priorities and opportunities for future research. This report summarizes updated key conclusions of the workshop with regards to micronutrients' intake and physiological role related to mother, placenta and fetus, as well as relevance for adverse pregnancy and long-term outcomes.

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Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom

Cited by 138 publications

References 22 publications

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Symposium on ‘Geographical and geological influences on nutrition’ Factors controlling the distribution of selenium in the environment and their impact on health and nutrition

Micronutrients in pregnancy: Current knowledge and unresolved questions

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