2017
DOI: 10.1016/s0168-8278(17)30557-3
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Low sensitivity to thrombomodulin in patients with cirrhosis; Impact of factor VIII increase and protein C deficiency

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“…In subsequent studies, however, multiple groups demonstrated increased thrombin generation in patients compared with controls using TM‐modified TGA . The hypercoagulable state of patients with cirrhosis relates, at least in part, to elevated plasma levels of factor VIII and decreased protein C which leads to an intrinsic resistance to the anticoagulant effect of TM in cirrhotic patients …”
Section: Introductionmentioning
confidence: 99%
“…In subsequent studies, however, multiple groups demonstrated increased thrombin generation in patients compared with controls using TM‐modified TGA . The hypercoagulable state of patients with cirrhosis relates, at least in part, to elevated plasma levels of factor VIII and decreased protein C which leads to an intrinsic resistance to the anticoagulant effect of TM in cirrhotic patients …”
Section: Introductionmentioning
confidence: 99%