Low Serotonin and Dopamine Metabolite Concentrations in Cerebrospinal Fluid From Bulimic Patients With Frequent Binge Episodes

Jimerson, David C.; Lesem, Michael D.; Kaye, Walter H.; Brewerton, Timothy D.

doi:10.1001/archpsyc.1992.01820020052007

Cited by 204 publications

(93 citation statements)

References 38 publications

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“…The effects of enhanced 5-HT function on other neurotransmitters (e.g., norepinephrine, acetylcholine, and peptides), such as the opiates (Brewerton et al 1992b) and CCK-8 (Brewerton et al 1992a;Lydiard RB et al 1993), may also be important in understanding these results. Nevertheless, the observation that bulimics and con trols demonstrated some diversity in their responses to both serotonergic agents is consistent with a seroto nin dysregulation hypothesis of bulimia nervosa (Brewerton et al 1986(Brewerton et al , 1989(Brewerton et al , 1991a(Brewerton et al , 1991b(Brewerton et al , 1992Brewer ton, in press;Jansen et al 1989;Goldbloom and Garfinkel, 1990;Jimerson et al 1990;Liebowitz, 1990).…”

Section: Discussionsupporting

confidence: 59%

Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls

Brewerton

Murphy

Jimerson

1994

Neuropsychopharmacol

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A wealth of data support a role for serotonin (5-HT) function in the mediation of satiety responses, that are impaired in patients with bulimia nervosa. Testmeal results are presented in which 26 bulimic patients and 17 normal controls were given in randomized, double-blind-fashion, placebo, and the 5-HT agents m-chlorophenylpiperazine (m-CPP, 0.5 mglkg p.o.) and L-tryptophan (L-TRP, 100 mglkg I. V.). Three and one-half hours after drug administration, subjects were allowed to eat and lib from a standardized testmeal of 3,500 calories, after which postprandial vomiting was not allowed. M-CPP, but not L-TRP, significantly decreased meal size in the combined group, the controls, and to a lesser extent, the bulimics (p � .06). Maximum m-CPP Serotonergic manipulations are known to result in marked changes in feeding behaviors, particularly sati ety responses (Blundell 1977(Blundell , 1984(Blundell , 1986Blundell and Latham, 1978, 1982Latham and Blundell 1979;Samanin et al. 1982;Silverstone and Goodall 1986;Garattini et al., 1988Garattini et al., , 1989, which are dysfunctional in bulimic patients (Owen et al. 1985;Chiodo and Latimer 1986;Kissileff et al. 1986). Pharmacologic en hancement of 5-HT neurotransmission in animals and concentrations were inversely correlated to the number of calories consumed in the total group. Following m-CPP, there were significant decreases in carbohydrate, protein, and fat intake in the total group of subjects. There were also trends for decreased carbohydrate and protein intake in the bulimics following m-CPP. There were trends for both m-CPP and L-TRP to reduce fat intake in the controls. Differences in the effects between m-CPP and L-TRP are likely due to differential involvement of 5-HT receptor subtypes at presynaptic and postsynaptic sites. These studies in humans confirm reports in animals that m-CPP decreases food intake, including carbohydrates, protein, and fat in a mixed testmeal.

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Section: Discussionsupporting

confidence: 59%

Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls

Brewerton

Murphy

Jimerson

1994

Neuropsychopharmacol

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“…Low DA metabolite concentrations in cerebrospinal fluid have been reported in BN subjects with frequent binge episodes (31,32). In addition, highly palatable foods induce potent release of DA into the nucleus accumbens (33), similar to drugs of abuse, and DA is a key neurotransmitter in novelty seeking and the development of addiction (4), which suggests that abnormal DA activity may contribute to binge-eating episodes and other impulsive behaviours associated with BN.…”

Section: Discussionmentioning

confidence: 99%

Behavioral Responses to Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa and Healthy Subjects

Grob¹,

Stern

Gamper³

et al. 2015

Biological Psychiatry

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“…Active bulimia nervosa (BN) sufferers display altered serotonin (5-hydroxytryptamine (5-HT)) system functioning, as evinced by reduced platelet binding of 5-HT uptake inhibitors (Marazziti et al, 1988;Steiger et al, 2000), reduced central 5-HT transporter availability (Tauscher et al, 2001), blunted neuroendocrine responses to 5-HT precursors and agonists (Levitan et al, 1997;Steiger et al, 2001a, b), and decreased 5-HT metabolites in cerebrospinal fluid (Jimerson et al, 1992). As food restriction is known to alter central 5-HT activity in animals (Huether et al, 1997;Zhou et al, 1996) and in humans (Goodwin et al, 1987), abnormal 5-HT function in BN could, reasonably, be a consequence of disordered eating.…”

Section: Introductionmentioning

confidence: 99%

Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

Steiger

Richardson

Israël

et al. 2005

Neuropsychopharmacol

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Findings show brain serotonin (5-hydroxytryptamine (5-HT)) activity to be altered in individuals who have had bulimia nervosa (BN), even after substantial remission of symptoms. Such findings could reflect persistent sequelae due to BN, or a vulnerability 'trait' that exists independently of active eating-disorder manifestations. We compared women with full-blown BN (BN; n ¼ 22), BN in remission (BN-R; n ¼ 11), and no eating or psychiatric disturbances (n ¼ 22) on measures of platelet [3 H]paroxetine binding, eating symptoms and psychopathology. The BN-R group showed normal-range scores on eating and psychopathological symptoms, but reductions in density (B max ) of binding sites for paroxetine similar to those obtained in the actively ill women. Both BN groups had substantially lower B max than did healthy controls. Our results corroborate other findings indicating recovered BN patients to have anomalous 5-HT functioning. While such effects could represent a lasting 'injury' to the system, reported covariations between personality traits and 5-HT indices in BN encourage us to favor the argument that some alterations of 5-HT activity (in this case, consistent with reduced transporter activity) represent a 'trait' associated with the risk of developing BN and/or associated psychopathology.

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Low Serotonin and Dopamine Metabolite Concentrations in Cerebrospinal Fluid From Bulimic Patients With Frequent Binge Episodes

Cited by 204 publications

References 38 publications

Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls

Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls

Behavioral Responses to Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa and Healthy Subjects

Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

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