Low serum 25‐hydroxyvitamin D3 levels and late delayed radiation‐induced brain injury in patients with nasopharyngeal carcinoma: A case–control study

Deng, Zhezhi; Li, Minping; Guo, Junjie; Zhou, Dongxiao; Huang, Xin; Huang, Yong-Xin; Huang, Hongbo

doi:10.1002/brb3.1892

Cited by 3 publications

(2 citation statements)

References 26 publications

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“… 13 Late delayed brain injury, characterized by radiation‐induced brain necrosis, represents the most frequent clinical manifestation following radiation exposure. 14 It manifests as either focal necrosis or diffuse white matter encephalopathy, with cerebral atrophy developing months to years following radiotherapy. MRI scans may reveal visible T1‐enhanced high signals.…”

Section: Radiation‐induced Brain Injurymentioning

confidence: 99%

“…Both acute and early delayed brain injuries are generally reversible, with symptoms markedly alleviated through dehydration treatment and cranial pressure reduction 13 . Late delayed brain injury, characterized by radiation‐induced brain necrosis, represents the most frequent clinical manifestation following radiation exposure 14 . It manifests as either focal necrosis or diffuse white matter encephalopathy, with cerebral atrophy developing months to years following radiotherapy.…”

Section: Radiation‐induced Brain Injurymentioning

confidence: 99%

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Microglia in radiation‐induced brain injury: Cellular and molecular mechanisms and therapeutic potential

Wang,

Tian,

Liu

et al. 2024

CNS Neurosci Ther

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BackgroundRadiation‐induced brain injury is a neurological condition resulting from radiotherapy for malignant tumors, with its underlying pathogenesis still not fully understood. Current hypotheses suggest that immune cells, particularly the excessive activation of microglia in the central nervous system and the migration of peripheral immune cells into the brain, play a critical role in initiating and progressing the injury. This review aimed to summarize the latest advances in the cellular and molecular mechanisms and the therapeutic potential of microglia in radiation‐induced brain injury.MethodsThis article critically examines recent developments in understanding the role of microglia activation in radiation‐induced brain injury. It elucidates associated mechanisms and explores novel research pathways and therapeutic options for managing this condition.ResultsPost‐irradiation, activated microglia release numerous inflammatory factors, exacerbating neuroinflammation and facilitating the onset and progression of radiation‐induced damage. Therefore, controlling microglial activation and suppressing the secretion of related inflammatory factors is crucial for preventing radiation‐induced brain injury. While microglial activation is a primary factor in neuroinflammation, the precise mechanisms by which radiation prompts this activation remain elusive. Multiple signaling pathways likely contribute to microglial activation and the progression of radiation‐induced brain injury.ConclusionsThe intricate microenvironment and molecular mechanisms associated with radiation‐induced brain injury underscore the crucial roles of immune cells in its onset and progression. By investigating the interplay among microglia, neurons, astrocytes, and peripheral immune cells, potential strategies emerge to mitigate microglial activation, reduce the release of inflammatory agents, and impede the entry of peripheral immune cells into the brain.

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Section: Radiation‐induced Brain Injurymentioning

confidence: 99%

Section: Radiation‐induced Brain Injurymentioning

confidence: 99%

Microglia in radiation‐induced brain injury: Cellular and molecular mechanisms and therapeutic potential

Wang,

Tian,

Liu

et al. 2024

CNS Neurosci Ther

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Mechanisms of radiation‐induced tissue damage and response

Zhou,

Zhu,

Liu

et al. 2024

MedComm

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Radiation‐induced tissue injury (RITI) is the most common complication in clinical tumor radiotherapy. Due to the heterogeneity in the response of different tissues to radiation (IR), radiotherapy will cause different types and degrees of RITI, which greatly limits the clinical application of radiotherapy. Efforts are continuously ongoing to elucidate the molecular mechanism of RITI and develop corresponding prevention and treatment drugs for RITI. Single‐cell sequencing (Sc‐seq) has emerged as a powerful tool in uncovering the molecular mechanisms of RITI and for identifying potential prevention targets by enhancing our understanding of the complex intercellular relationships, facilitating the identification of novel cell phenotypes, and allowing for the assessment of cell heterogeneity and spatiotemporal developmental trajectories. Based on a comprehensive review of the molecular mechanisms of RITI, we analyzed the molecular mechanisms and regulatory networks of different types of RITI in combination with Sc‐seq and summarized the targeted intervention pathways and therapeutic drugs for RITI. Deciphering the diverse mechanisms underlying RITI can shed light on its pathogenesis and unveil new therapeutic avenues to potentially facilitate the repair or regeneration of currently irreversible RITI. Furthermore, we discuss how personalized therapeutic strategies based on Sc‐seq offer clinical promise in mitigating RITI.

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Effects of dietary 25-hydroxyvitamin D3 on growth, calcium-phosphorus metabolism, lipid metabolism and immunity of Litopenaeus vannamei at low salinity

Zhu,

Lu,

Lai

et al. 2024

Aquaculture Reports

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Low serum 25‐hydroxyvitamin D3 levels and late delayed radiation‐induced brain injury in patients with nasopharyngeal carcinoma: A case–control study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 26 publications

Microglia in radiation‐induced brain injury: Cellular and molecular mechanisms and therapeutic potential

Microglia in radiation‐induced brain injury: Cellular and molecular mechanisms and therapeutic potential

Mechanisms of radiation‐induced tissue damage and response

Effects of dietary 25-hydroxyvitamin D3 on growth, calcium-phosphorus metabolism, lipid metabolism and immunity of Litopenaeus vannamei at low salinity

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