Low serum albumin levels and new-onset atrial fibrillation in the ICU: a prospective cohort study

Beek, Dianne E C van; Kuijpers, Y.; Königs, Marc H H; Horst, Iwan C. C. van der; Scheeren, Thomas

doi:10.1016/j.jcrc.2019.11.011

Cited by 15 publications

(13 citation statements)

References 16 publications

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“…The details of the reasons to exclude them are described in Supplementary Table 3. Finally, 9 (7)(8)(9)(10)(11)(20)(21)(22)(23) eligible studies (10 cohorts) with 32,130 individuals were included.…”

Section: Literature Searchmentioning

confidence: 99%

“…Hypoalbuminemia, usually defined as <35 g/L, is a significant indicator of malnutrition, inflammation, or cachexia and has been recognized as a robust biomarker for various noncardiovascular and cardiovascular diseases (3,4) in the general population or patients with coexisting diverse comorbidities (5,6). Several studies and our previous study have reported the malnutrition status and the risk of AF (7)(8)(9)(10)(11) as an indicator of malnutrition, however, the serum albumin and associated risk of AF is inconclusive. Moreover, the dose-response relationship of albumin and AF is still unclear.…”

Section: Introductionmentioning

confidence: 96%

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Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis

Wang

Xiao

et al. 2021

Front. Nutr.

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Background: The dose–response association between serum albumin and atrial fibrillation is not well known. This study aims to assess the relationship between albumin and atrial fibrillation and the potential dose–response effect.Methods: Studies reported that the serum albumin and AF were identified by searching the EMBASE, PubMed, and Cochrane Library databases. The potential dose–response effect was performed by using a stage robust error meta-regression.Results: Nine studies were included with a total of 32,130 individuals. Patients with high albumin level were associated with a decreased risk of atrial fibrillation compared with patients with low serum albumin (OR[odds ratio]: 0.62, 95% CI [0.44, 0.89]; I2 = 76%; P = 0.009). In the dose–response analysis, for each 10 g/L increase in serum albumin level, the risk of atrial fibrillation decreased by 36% (95% CI: 0.51–0.81, I2 = 87%, P < 0.001). Furthermore, a significant negative linear relationship between serum albumin and the risk of atrial fibrillation (Pnonlinearity = 0.33) was found.Conclusion: Our dose–response meta-analysis suggests that low serum albumin level is associated with an increased risk of atrial fibrillation. Further studies are needed to explore the effect of induction of elevated serum albumin levels on the prevention of atrial fibrillation.

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Section: Literature Searchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis

Wang

Xiao

et al. 2021

Front. Nutr.

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“…Another study showed that lower ALB was a risk factor for paroxysmal AF [ 19 ]. A prospective cohort study indicated that low ALB was associated with the risk and the number of attacks of NOAF for ICU patients [ 20 ]. In addition, several studies have shown that the relationship between albumin and AF may differ by sex.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study to Determine the Association Between Serum Albumin Levels and Atrial Fibrillation by Sex in 950 Patients from a Single Center in China

et al. 2022

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Background It remains unclear whether there is a sex difference in the association between serum albumin (ALB) and atrial fibrillation (AF). This retrospective case-control study from a single center in China aimed to determine the association between serum ALB levels and AF by sex in 950 patients. Material/Methods Data of 950 AF patients and 963 age- and sex-matched non-AF patients with sinus rhythm were collected and analyzed retrospectively. Clinical baseline data were analyzed using the t test or Mann-Whitney U test, analysis of variance (ANOVA), and chi-square test. The interrelationships were determined by Pearson correlation analysis, and multivariate logistic regression analysis was performed to adjust for covariables. Results ALB levels of AF patients were significantly lower in both sexes ( P <0.05), especially paroxysmal AF. ALB was positively correlated with total cholesterol (TC) (r=0.359, P <0.05), low-density lipoprotein cholesterol (LDL-C) (r=0.283, P <0.05), and serum apolipoprotein A1 (APOA1) (r=0.429, P <0.05) and was negatively correlated with serum creatinine (SCr) (r=0.129, P <0.05) in patients with AF. We found an independent negative association between ALB levels and AF in men after adjusting for confounding factors (OR=0.889, 95% CI: 0.845–0.934, P <0.05). Conclusions In patients at a single center in China, low serum ALB levels in male patients were significantly associated with AF. These findings support those from previous studies in other populations and highlight the importance of monitoring and treating the cause of hypoalbuminemia in cardiac patients.

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“…In serology, only albumin was associated with the prognostic outcome. Albumin has been shown by the team of Dianne E to be an independent predictor, and it is even superior in critical conditions (37). Albumin reflects a certain extent on the nutritional status of the body.…”

Section: Risk Factors For Recurrence Factorsmentioning

confidence: 99%

A Simple Logistic Regression Model for Predicting the Likelihood of Recurrence of Atrial Fibrillation Within 1 Year After Initial Radio-Frequency Catheter Ablation Therapy

Jia

Mou

et al. 2022

Front. Cardiovasc. Med.

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BackgroundThe clinical factors associated with the recurrence of atrial fibrillation (Af) in patients undergoing catheter ablation (CA) are still ambiguous to date.Purpose1. To recognize preoperative serologic factors and clinical features associated with Af recurrence after the first ablation treatment. 2. To Develop a Logical Regression Model for Predicting the Likelihood of Recurrence Within 1 Year After the Initial Radio-Frequency Catheter Ablation (RFCA) Therapy.MethodsAtrial fibrillation patients undergoing RFCA at our institution from January 2016 to June 2021 were included in the analysis (n = 246). A combined dataset of relevant parameters was collected from the participants (clinical characteristics, laboratory results, and time to recurrence) (n = 200). We performed the least absolute shrinkage and selection operator (Lasso) regression with 100 cycles, selecting variables present in all 100 cycles to identify factors associated with the first recurrence of atrial fibrillation. A logistic regression model for predicting whether Af would recur within a year was created using 70% of the data as a training set and the remaining data to validate the accuracy. The predictions were assessed using calibration plots, concordance index (C-index), and decision curve analysis.ResultsThe left atrial diameter, albumin, type of Af, whether other arrhythmias were combined, and the duration of Af attack time were associated with Af recurrence in this sample. Some clinically meaningful variables were selected and combined with recognized factors associated with recurrence to construct a logistic regression prediction model for 1-year Af recurrence. The receiver operating characteristic (ROC) curve for this model was 0.8695, and the established prediction model had a C-index of 0.83. The performance was superior to the extreme curve in the decision curve analysis.ConclusionOur study demonstrates that several clinical features and serological markers can predict the recurrence of Af in patients undergoing RFCA. This simple model can play a crucial role in guiding physicians in preoperative evaluation and clinical decision-making.

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Low serum albumin levels and new-onset atrial fibrillation in the ICU: a prospective cohort study

Cited by 15 publications

References 16 publications

Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis

Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis

A Retrospective Study to Determine the Association Between Serum Albumin Levels and Atrial Fibrillation by Sex in 950 Patients from a Single Center in China

A Simple Logistic Regression Model for Predicting the Likelihood of Recurrence of Atrial Fibrillation Within 1 Year After Initial Radio-Frequency Catheter Ablation Therapy

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