Low Serum Butyrylcholinesterase Activity as a Prognostic Marker of Mortality Associates with Poor Cardiac Function in Acute Myocardial Infarction

Qi, Ximing; Tan, Qiang; Yang, Hongmei; Qi, Xiangqian

doi:10.7754/clin.lab.2015.151013

Cited by 11 publications

(7 citation statements)

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“…Low BChE activity is thought to reflect decreased availability of ACh and thus an altered cholinergic homeostasis and several studies have found that low BChE activity is associated with severe systemic inflammation 26 , 27 , 28 and a significant higher mortality after sepsis and cardiac events. 4 , 29 , 30 Interestingly, in terms of our present findings, inflammation has long been thought to play a role in SIDS and as far back as 1889 mild inflammatory changes in the walls of the bronchioles were observed in SIDS infants. 31 …”

Section: Discussionsupporting

confidence: 70%

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

2022

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Section: Discussionsupporting

confidence: 70%

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

2022

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“…The assay of the BuChE cholinesterase activity is a proven sensitive method for monitoring exposure to OP compounds (Do Nascimento et al, 2017;Eddleston et al, 2008;Maretto et al, 2012a;Oliveira-Silva et al, 2000;Pohanka, 2013). Interestingly, the measurement of BuChE has been proposed as a potential marker for predicting cardiovascular risk (Sulzgruber et al, 2015;Sun et al, 2016), which further reinforces the importance of measuring this enzyme activity in studies involving OP exposure and cardiovascular effects. Measurement of the AChE activity within the brainstem, where the main nuclei mediating cardiovascular reflexes are located (for review Dampney, 2016;Salman, 2016), complemented the results obtained for the plasma BuChE.…”

Section: Discussionmentioning

confidence: 97%

Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide: Possible short and long term clinical implications

et al. 2018

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Although it is well-established that severe poisoning by organophosphorus (OP) compounds strongly affects the cardiorespiratory system, the effects of sub-lethal exposure to these compounds on the neural control of cardiovascular function are poorly explored. The aim of this study was to evaluate the effects of acute sub-lethal exposure to chlorpyrifos (CPF), a commonly used OP insecticide, on three basic reflex mechanisms involved in blood pressure regulation, the peripheral chemoreflex, the baroreflex and the Bezold-Jarisch reflex. Adult male Wistar rats were injected intraperitoneally with a single dose of CPF (30 mg/kg) or saline (0.9%). 24 h after injections, cardiovascular reflexes were tested in awake rats. Potassium cyanide (KCN) and phenylbiguanide (PBG) were injected intravenously to activate the chemoreflex and the Bezold-Jarisch reflex, respectively. The baroreflex was activated by phenylephrine and sodium nitroprusside infusions. Blood samples were taken for measurements of butyrylcholinesterase (BChE) activity while acetylcholinesterase (AChE) activity was measured in brainstem samples. Animals treated with CPF presented signs of intoxication such as ataxia, tremor, lacrimation, salivation, tetany, urination and defecation. The hypertensive and the bradycardic responses of the chemoreflex as well as the hypotensive and bradycardic responses of the Bezold-Jarisch reflex were attenuated in CPF treated animals (P < 0.05). Concerning the baroreflex responses, CPF treatment reduced the bradycardia plateau, the range and the gain of the reflex (P < 0.05). Plasma BChE and brainstem AChE were both reduced significantly after CPF treatment (P < 0.05). Our results showed that acute sub-lethal exposure to CPF impairs the cardiovascular responses of homeostatic and defensive cardiovascular reflexes. These effects are associated with a marked inhibition of plasma BChE and brainstem AChE.

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“…Although AChE and BChE are reported to influence the incidence and mortality of coronary artery disease (1,2), the association of ChE deficiency with SSS is not clear. AChE plays a key role in cholinergic neurotransmission, and BChE plays a supplementary role to AChE.…”

Section: Discussionmentioning

confidence: 99%

Sick Sinus Syndrome Observed in a Patient with Cholinesterase Deficiency

et al. 2019

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A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.

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Low Serum Butyrylcholinesterase Activity as a Prognostic Marker of Mortality Associates with Poor Cardiac Function in Acute Myocardial Infarction

Cited by 11 publications

References 0 publications

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide: Possible short and long term clinical implications

Sick Sinus Syndrome Observed in a Patient with Cholinesterase Deficiency

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