Low Serum Calcium Levels Contribute to Larger Hematoma Volume in Acute Intracerebral Hemorrhage

Abstract

The online-only Data Supplement is available with this article at http://stroke.ahajournals.org/lookup/suppl

Association Between Serum Calcium Level and Extent of Bleeding in Patients with Intracerebral Hemorrhage

“…Our findings corroborate and extend previous evidence of a relationship between lower levels of serum calcium and higher baseline ICH volume, 4 and they provide further insights into the possible mechanisms for this association. In addition, we provide important novel data showing that a low serum calcium level is also associated with an increased risk of hematoma expansion.…”

“…2,3 It has been suggested that a lower serum calcium level is associated with higher hematoma volume in patients with ICH, as well as hemorrhagic transformation after intravenous thrombolysis for acute ischemic stroke. 4,5 However, systematic studies on the topic are currently lacking, and the underlying mechanisms are poorly understood. One possibility is that serum calcium is involved in platelet function and in several steps of the coagulation cascade.…”

CKD is associated with recurrent ischemia but not with hemorrhagic transformation in acute ischemic stroke patients

“…Nevertheless, this result is inappropriate with the expectation because ionized calcium is an essential cofactor for coagulation cascade. 24 As a limitation of this study, we did not show ionized calcium levels and albumin-corrected calcium levels. However, there was no difference between the groups regarding to serum albumin levels.…”

Prognostic Significance of Serum Calcium Level in a Sample of Egyptian Patients With Intracerebral Hemorrhage.

“…Data from experimental studies showed an association between Ca levels and changes in bleeding and clotting time [11][12] , thus it was suggested that Ca could play a role in haemostasis in the setting of acute ICH 13 . Recently, few data were published on the relation between serum Ca level and the initial hematoma volume 14 as well as outcomes after ICH [13][14][15] .…”

“…Recently, few data were published on the relation between serum Ca level and the initial hematoma volume 14 as well as outcomes after ICH [13][14][15] . However, the underlying mechanisms are poorly understood 14 .…”