Low serum folate status in the second trimester increase the risk of low birthweight in Chinese women

Zhu, Xinyuan; Wei, Luyun; Cao, Dehao; Liu, Chaoqun; Tian, Jiarong; Liu, Yu; Huang, Shengzhu; Ou, Liqian; Yang, Xiaobo; Mo, Zengnan

doi:10.1111/jog.13757

Cited by 5 publications

(2 citation statements)

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“…In addition, although a previous meta-analysis ( 4 ) revealed that consuming FA supplements during periconception or early pregnancy could reduce the risk of ASD in offspring, emerging evidence shows that low plasma/serum folate concentration in the second and third trimesters of pregnancy is also likely associated with increased risks of physical health issues (e.g., low birthweight) ( 32 ) and cognitive development (e.g., language development) in offspring ( 33 , 34 ). Folate plays an essential role in DNA methylation as a provider of methyl groups ( 6 ), which is considered crucial for the development of the central nervous system and is implicated in the formation of fundamental brain structures ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Examining associations of folic acid supplements administered to mothers during pre-conceptional and prenatal periods with autism spectrum disorders in their offspring: insights from a multi-center study in China

Jiang,

Guo,

Kuang

et al. 2024

Front. Public Health

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ObjectiveTo investigate the relationship between maternal folic acid (FA) supplementation during the pre-conceptional and prenatal periods and the subsequent risk of autism spectrum disorder (ASD) in offspring.MethodsA total of 6,049 toddlers aged 16–30 months were recruited from August 2016 to March 2017 for this cross-sectional study conducted in China. The parents of the enrolled toddlers provided information on maternal supplemental FA, socio-demographic information, and related covariates. Standard diagnostic procedures were implemented to identify toddlers with ASD.ResultsAmong the 6,049 children included in the study, consisting of 3,364 boys with an average age of 22.7 ± 4.1 months, a total of 71 children (1.2%) were diagnosed with ASD. Mothers who did not consume FA supplements during the prenatal period were found to have a significantly increased risk of having offspring with ASD, in comparison to those who were exposed to FA supplements (odds ratio [OR] = 2.47). However, we did not find a similar association during the pre-conceptional period. Compared to mothers who consistently used FA supplements from pre-conception to the prenatal period, those who never used FA supplements were statistically significantly associated with a higher risk of ASD in their offspring (OR = 2.88).ConclusionThis study indicated that providing continuous maternal FA supplementation during the pre-conceptional and prenatal periods may decrease the risk of ASD in offspring. The prenatal period is considered to be the most crucial time for intervention.

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Section: Discussionmentioning

confidence: 99%

Examining associations of folic acid supplements administered to mothers during pre-conceptional and prenatal periods with autism spectrum disorders in their offspring: insights from a multi-center study in China

Jiang,

Guo,

Kuang

et al. 2024

Front. Public Health

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“…Plasma folate, a transport form of folate to the tissue and to the fetus (6) , plays crucial roles in maintaining maternal and offspring health. Accumulating evidence shows that a low plasma or serum folate concentration in mid-to late pregnancy is likely associated with increased risks of pre-eclampsia (7) , preterm birth (8) , low birth weight (9) and poor language development in young children (10) . Animal models also showed that folate deficiency during lactation could alter cerebellar synapsin expression in offspring (11) .…”

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confidence: 99%

Trends and influencing factors of plasma folate levels in Chinese women at mid-pregnancy, late pregnancy and lactation periods

Zhou

et al. 2020

Br J Nutr

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Folate status for women during early pregnancy has been investigated, but data for women during mid-pregnancy, late pregnancy, or lactation are sparse or lacking. Between May and July 2014, we conducted a cross-sectional study in 1211 pregnant and lactating women from three representative regions in China. Approximately 135 women were enrolled in each stratum by physiologic periods (mid-pregnancy, late pregnancy, or lactation) and regions (south, central, or north). Plasma folate concentrations were measured by microbiological assay. The adjusted medians (interquartile ranges [IQR]) of folate concentration decreased from 28.8 (19.9 – 38.2) nmol/L in mid-pregnancy to 18.6 (13.2 – 26.4) nmol/L in late pregnancy, and to 17.0 (12.3 – 22.5) nmol/L in lactation (P for trend <0.001). Overall, lower folate concentrations were more likely to be observed in women residing in northern region, with younger age, higher pre-pregnancy BMI, lower education or multiparity, and in lactating women underwent a caesarean delivery or breastfed exclusively. In total, 380 (31.4%) women had a suboptimal folate status (folate concentration <13.5 nmol/L). Women of being at late pregnancy and lactation, residing in northern region, having multiparity and low education level had a higher risk of suboptimal folate status, while those with older age had a lower risk. In conclusion, maternal plasma folate concentrations decreased as pregnancy progressed, and influenced by geographic region and maternal social-demographic characteristics. Future studies are warranted to assess the necessity of folic acid supplementation during later pregnancy and lactation especially for women at a higher risk of folate depletion.

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Maternal folate levels during pregnancy and offspring brain development in late childhood

Zou¹,

Marroun²,

Cecil³

et al. 2021

Clinical Nutrition

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Low serum folate status in the second trimester increase the risk of low birthweight in Chinese women

Abstract: Low serum folate levels in the second trimester significantly increases the risk of LBW amongst Chinese women with singleton pregnancies.

Cited by 5 publications

References 34 publications

Examining associations of folic acid supplements administered to mothers during pre-conceptional and prenatal periods with autism spectrum disorders in their offspring: insights from a multi-center study in China

Examining associations of folic acid supplements administered to mothers during pre-conceptional and prenatal periods with autism spectrum disorders in their offspring: insights from a multi-center study in China

Trends and influencing factors of plasma folate levels in Chinese women at mid-pregnancy, late pregnancy and lactation periods

Maternal folate levels during pregnancy and offspring brain development in late childhood

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