Low serum level of mannan-binding lectin is a determinant for pregnancy outcome in women with recurrent spontaneous abortion

Kruse, Christina; Rosgaard, Anni; Steffensen, Rudi; Varming, Kim; Jensenius, Jens C.; Christiansen, Ole Bjarne

doi:10.1067/mob.2002.126846

Cited by 89 publications

(88 citation statements)

References 20 publications

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“…Before, low MBL serum levels were found to be associated with an increased risk of unexplained recurrent miscarriage. 10 -12 An association with low MBL level conferring MBL2 variant genotypes was reported in a genotyping study, 13 whereas another study conducted by another group did not ascertain any MBL2 genotype differences between groups of women with recurrent miscarriages and those without. 14 Our study has important limitations that require consideration.…”

Section: Discussionmentioning

confidence: 99%

“…6 Previously, low MBL serum levels were found to be associated with an increased risk of unexplained recurrent miscarriage. 10 -12 An association with MBL2 variant genotypes was observed in a genotyping study, 13 whereas another study, however, did not ascertain any MBL2 genotype differences between groups of women with recurrent miscarriages and those without. 14 The proper function of MBL, an acute-phase protein of the liver, is essential for opsonisation of a multitude of different bacteria and yeast.…”

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confidence: 99%

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Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth

Bodamer

Mitterer

Mäurer

et al. 2006

Genetics in Medicine

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Purpose: Human mannose-binding lectin, encoded by the MBL2 gene, is an important component of innate immunity and an important regulator of inflammatory processes. MBL2 gene polymorphisms are associated with an increased risk of neonatal infections and some data suggest a relation between the maternal MBL2 genotype and the risk of premature delivery. In this study, we evaluated whether there is an association between the fetal MBL2 genotype and prematurity. Methods: A microarray-based on-chip PCR method was used to simultaneously detect five common MBL2 polymorphisms (codon 52, 54, 57; promoter -550, -221) in 204 DNA samples isolated from archival blood cards. MBL2 genotypes of infants born before the 36 th week of pregnancy (N ϭ 102) were compared to a control group of infants born at term after the 37 th week (N ϭ 102). Results: The frequency of the codon 52 polymorphism was significantly higher in the pre-term group compared to the term group (10.8% versus 4.9%, P ϭ 0.04), while the frequency of the codon 54 polymorphism was equal in both groups (11.3% versus 11.8%). Interestingly, carriers of genotypes (O/O) likely conferring deficient MBL plasma levels were more common in the group of premature birth (9.8% versus 2.9%, P ϭ 0.05), while the promoter -550 C/C genotype was underrepresented in the pre-term birth group (24.5% versus 39.2%, P ϭ 0.03). Conclusion: Our data add to the knowledge about genetic predisposition to prematurity and suggest that the fetal MBL2 genotype might be an additional genetic factor contributing to the risk of premature delivery. Genet Med 2006:8(8):518-524.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth

Bodamer

Mitterer

Mäurer

et al. 2006

Genetics in Medicine

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“…Patients with MBL levels of ≤100 ng/ml had a higher abortion rate than patients with normal MBL concentrations (p<0.05). The median birth weight of children who were born at term to women with recurrent spontaneous abortion was 287 g less in the women with MBL levels of ≤100 ng/ml than in the women with normal concentrations (p=0.04) (Kruse et al 2002).…”

Section: Tsutsumi Et Al Suggested That Possession Of the Minori-mentioning

confidence: 99%

Evaluation of lectin pathway activity and mannan-binding lectin levels in the course of pregnancy complicated by diabetes type 1, based on the genetic background

Pertyńska−Marczewska

Cedzyński

Świerzko

et al. 2009

Arch. Immunol. Ther. Exp.

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Introduction: There are numerous indications that either mannan-binding lectin (MBL) deficiency or its excessive activity are associated with adverse pregnancy outcomes. High MBL concentrations and corresponding MBL2 genotypes were shown to be associated with microvascular complications in type 1 diabetes. The aim of this study was to evaluate levels of MBL and MBL-dependent activity of the lectin pathway (LP) of complement in the course of pregnancy in diabetic mothers, based on genetic background. Materials and Methods: These parameters were determined in samples from healthy non-pregnant (control), diabetic non--pregnant, healthy pregnant, and pregnant diabetic women. Results: No significant differences in median MBL levels or LP activities were found in any study group compared to the control. However, statistically significant differences in MBL levels were noted during pregnancy between the 1st and 3rd trimesters in both healthy controls and pregnant diabetics. With regard to LP values, similar trends were evident, but statistically significant results were obtained only in the healthy pregnant group. When data analysis was confined to patients carrying the A/A (wild-type) MBL2 genotype, an increase in MBL level during pregnancy (in both healthy and diabetic pregnant women) was still observed. Similarly, LP activity increased during both healthy and diabetic pregnancies, significantly so for the former. Conclusions: Diabetes, an autoimmune disease, is a serious complication of pregnancy. Therefore, determination of MBL status might be beneficial in identifying type 1 diabetic patients who are at increased risk of developing both vascular complications and poor pregnancy outcomes.

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“…There they express IL-10, TGFβ, and TNFα [10]. TNF-α is produced by all CD4+ T cells [11,[72][73][74][75]. IL-10 inhibits macrophages and Th1 cell proliferation [76,77].…”

Section: T-helper Lymphocyte-2 Cellsmentioning

confidence: 99%

Immunogenetic contributions to recurrent pregnancy loss

Grimstad

Krieg

2016

J Assist Reprod Genet

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While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though multiple causes are known (including structural, hormonal, infectious, autoimmune, and thrombophilic causes), after evaluation, roughly half of all cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic dilemma in addition to incurring much physical and emotional morbidity. Immunogenetic causes have been postulated to contribute to these cases of RPL. Natural Killer cell, T cell expression pattern changes in the endometrium have both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine allelic variations have also been studied as etiologies for RPL. Some of the results have been promising, however the studies are small and have not yet put forth outcomes that would change our current diagnosis and management of RPL. Larger database studies are needed with stricter control criteria before reasonable conclusions can be drawn.

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Low serum level of mannan-binding lectin is a determinant for pregnancy outcome in women with recurrent spontaneous abortion

Cited by 89 publications

References 20 publications

Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth

Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth

Evaluation of lectin pathway activity and mannan-binding lectin levels in the course of pregnancy complicated by diabetes type 1, based on the genetic background

Immunogenetic contributions to recurrent pregnancy loss

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