Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Abstract

Introduction: Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aims to evaluate serum Metrnl levels in T2DM patients and determine the relationship between serum Metrnl levels and insulin resistance in these patients. Material and methods: This cross-sectional study was conducted among 150 participants. The study was carried out between June 2019 and December 2019 at the internal medicine outpatient clinic of a tertiary university hospital. The participants were divided into three groups: group 1 (control group, n = 50), group 2 (newly diagnosed T2DM, n = 50), and group 3 (long-standing diagnosed T2DM, n = 50). An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed. Results: There was no statistically significant difference between the gender (p = 0.468) and age (p = 0.067) characteristics of the three groups. The Metrnl (subfatin) levels of the participants were as follows: control group-20.05 (1.56-103.78); newly diagnosed T2DM group-2.62 (1.25-103.78); and long-standing diagnosed T2DM group-2.01 (0.80-19.84) pg/mL. The Metrnl (subfatin) levels of the participants in the control group were higher than in the participants in the newly diagnosed T2DM and long-standing diagnosed T2DM groups (p < 0.001). Subfatin demonstrated a negative correlation with insulin and HOMA-IR in the control group and long-standing diagnosed T2DM group. Conclusions: The subfatin level was found to be higher in the healthy control group than in both diabetic patient groups. Subfatin level showed negative correlation with both insulin level and HOMA index. There was a relationship between subfatin and insulin resistance. Low levels of subfatin in the diabetic patient groups may play a role in the pathogenesis of T2DM by increasing insulin resistance.

Hepatic Meteorin-like and Krüppel-like Factor 3 are Associated with Weight Loss and Liver Injury

“…Article Thieme ic individuals [19]. Other studies reported lower METRNL concentration in patients with T2D with a gradual decrease from healthy controls to that in more advanced stages of T2D [18]. Interestingly, Pellitero et al reported circulating METRNL levels before and after laparoscopic sleeve gastrectomy (another bariatric surgery technique).…”

“…METNRL was also found to be related to the browning of white fat depots and improved glucose tolerance in obese/diabetic mice [16,17]. However, data on circulating METNRL concentration in subjects with T2D are conflicting [18][19][20][21].…”

Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

“…In patients with stable angina pectoris and atrial fibrillation in stable disease, ELA levels will be reduced (Cui et al, 2021;Diakowska et al, 2021). Further, compared with healthy people, serum ELA is lower in patients with diabetic nephropathy (Onalan et al, 2020). In patients with CKD, the serum ELA level gradually decreases with the reduced GFR level, with the lowest values observed in patients with CKD5 (Lu et al, 2020).…”

The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

“…Moreover, the same research group has documented that increased Metrnl plasma concentration resulted in increased EE, and improved glucose tolerance and anti-inflammatory cytokines [ 336 ]. In addition, the plasma Metrnl level has been reported to be lower in people with T2D [ 340 ] and osteoarthritis [ 341 ] when compared to healthy subjects. On the other hand, some research reported a higher level of Metrnl in individuals with obesity [ 342 ], and a positive association of Metrnl with BMI, waist circumference, total cholesterol, triglyceride, and low-density lipoprotein cholesterol in individuals with T2D [ 342 , 343 ].…”