Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes

Chen, Haibing; Lu, Junxi; Xie, Chen; Yu, Haoyong; Zhang, Lei; Bao, Yuqian; Lu, Fengdi; Tang, Junling; Gu, Chenchen; Jia, Weiping

doi:10.1093/jmcb/mjs032

Cited by 24 publications

(19 citation statements)

References 9 publications

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“…Furthermore, classification analyses showed that this single protein, plus BMI and age, performed well in predicting group assignment (AUC = 0.79). Based on previous IR research, this relationship was as expected because a reduction in ficolin-3, a protein structurally and functionally similar to FCN2, has previously been identified as a biomarker of type 2 diabetes [36]. Moreover, FCN2 was also found to be related to CSF AD pathology in our cohort; with a significant negative association found with CSF Aβ, driven by the IR group.…”

Section: Discussionsupporting

confidence: 84%

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

et al. 2017

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BackgroundInsulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influence of IR on AD using plasma and cerebrospinal fluid (CSF) biomarkers related to IR and AD in cognitively healthy men. We also aimed to characterise the shared protein signatures between IR and AD.MethodsFifty-eight cognitively healthy men, 28 IR and 30 non-IR (age and APOE ε4 matched), were drawn from the Metabolic Syndrome in Men study in Kuopio, Finland. CSF AD biomarkers (amyloid β-peptide (Aβ), total tau and tau phosphorylated at the Thr181 epitope) were examined with respect to IR. Targeted proteomics using ELISA and Luminex xMAP assays were performed to assess the influence of IR on previously identified CSF and plasma protein biomarker candidates of AD pathology. Furthermore, CSF and plasma SOMAscan was performed to discover proteins that associate with IR and CSF AD biomarkers.ResultsCSF AD biomarkers did not differ between IR and non-IR groups, although plasma insulin correlated with CSF Aβ/tau across the whole cohort. In total, 200 CSF and 487 plasma proteins were differentially expressed between IR and non-IR subjects, and significantly enriched pathways, many of which have been previously implicated in AD, were identified. CSF and plasma proteins significantly associated with CSF AD biomarkers were also discovered, and those sensitive to both IR and AD were identified.ConclusionsThese data indicate that IR is not directly related to the level of CSF AD pathology in cognitively healthy men. Proteins that associated with both AD and IR are potential markers indicative of shared pathology.Electronic supplementary materialThe online version of this article (doi:10.1186/s13195-017-0258-6) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 84%

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

et al. 2017

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“…Preeclamptic patients had significantly lower ficolin-2 and ficolin-3 concentrations than healthy non-pregnant and pregnant women [40]. Recently, research showed that plasma ficolin-3, a kind of soluble PRR within the lectin pathway varied significantly between individuals with NGT and those with T2DM [41]. Ficolin-3 was found down-regulated in GDM and the next research will be to document the correlation between the two differentially regulated proteins and important consequences in GDM.…”

Section: Discussionmentioning

confidence: 96%

Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus

Zhao

Wang

et al. 2015

Acta Diabetol

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“…However, the present study was contrary to the previous report that the participants who developed GDM showed downregulated ficolin‐3, as assessed by multiplexed isobaric tandem mass tag labeling combined with liquid chromatography mass spectrometry and Western blot analysis. The inconsistency was also reported in type 2 diabetes mellitus. The major differences in these studies was the utilization of different sample sizes, various types of specimens (plasma, serum) and different test methods (e.g., liquid chromatography mass spectrometry, Western blot analysis, ELISA).…”

Section: Discussionmentioning

confidence: 99%

Ficolin‐3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women

Yuan

Shi

Wang

et al. 2017

J of Diabetes Invest

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Aims/IntroductionTo establish that the ficolin‐3/adiponectin ratio is a predictor for gestational diabetes mellitus (GDM) and is eligible for screening tests for GDM.Materials and MethodsA prospective cohort study of 86 pregnant women who developed GDM and 273 normal glucose tolerance participants was carried out. Maternal serum ficolin‐3, adiponectin levels were investigated at 16–18 weeks of gestation using enzyme‐linked immunosorbent assay.ResultsCompared with the normal glucose tolerance group, the GDM group showed significantly higher levels of ficolin‐3 and the ratio of ficolin‐3/adiponectin; and decreased levels of adiponectin between 16–18 weeks of gestation (P < 0.05 or P < 0.01). The cut‐off values for the ratio of ficolin‐3/adiponectin (≥1.06; sensitivity 90.9%, specificity 96.5%) to discriminate the pregnant women who developed GDM from the non‐diabetic cases were identified using receiver operating characteristic analysis. Using binary logistic regression analysis, ficolin‐3, retinol‐binding protein‐4 and adiponectin, but not C‐reactive protein, triglyceride and free fatty acids were shown as predictive factors for GDM.ConclusionsThe ratio of ficolin‐3/adiponectin at 16–18 weeks of gestation was changed in pregnant women who subsequently developed GDM, and might provide effective early predicting and screening for GDM.

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Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes

Cited by 24 publications

References 9 publications

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus

Ficolin‐3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women

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