Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

Kim, Jae Hwa; Kim, Gotak; Yoon, Siyeong; Lee, Hyun Il; Ko, Kyung Rae; Lee, Sang Cheol; Kim, Do Kyung; Shin, Jaeyeon; Lee, So‐Young

doi:10.1186/s12891-021-04231-7

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…These results align with a recent systematic review that showed an association between metabolic syndrome and RCD [8]. In Kim et al's (2021) study, significantly lower levels of vitamin B12, vitamin D, and phosphorus were found in serum samples of patients with RCD compared with control group patients [53]. In addition, the higher vitamin D levels were calculated to have a significantly lower odds ratio (0.89, 95% CI 08.…”

Section: Discussionsupporting

confidence: 84%

The Usefulness of Serological Inflammatory Markers in Patients with Rotator Cuff Disease—A Systematic Review

Leung

Ngai

2022

Medicina

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Background and Objectives: Rotator cuff disease (RCD) is a prominent musculoskeletal pain condition that spans a variety of pathologies. The etiology and precise diagnostic criteria of this condition remain unclear. The current practice of investigating the biochemical status of RCD is by conducting biopsy studies but their invasiveness is a major limitation. Recent biochemical studies on RCD demonstrate the potential application of serological tests for evaluating the disease which may benefit future clinical applications and research. This systematic review is to summarize the results of available studies on serological biochemical investigations in patients with RCD. Methods: An electronic search on databases PubMed and Virtual Health Library was conducted from inception to 1 September 2021. The inclusion criteria were case-control, cross-sectional, and cohort studies with serological biochemical investigations on humans with RCD. Methodological quality was assessed using the Study Quality Assessment Tool for Observational Cohort and Cross-sectional studies from the National Heart, Lung, and Blood Institute. Results: A total of 6008 records were found in the databases; of these, 163 full-text studies were checked for inclusion and exclusion criteria. Nine eligible studies involving 984 subjects with RCD emerged from this systematic review. The quality of the studies found ranged from poor to moderate. In summarizing all the studies, several fatty acids, nonprotein nitrogen, interleukin-1 β, interleukin-8, and vascular endothelial growth factor were found to be significantly higher in blood samples of patients with RCD than with control group patients ,while Omega-3 Intex, vitamin B12, vitamin D, phosphorus, interleukin-10, and angiogenin were observed to be significantly lower. Conclusions: This is the first systematic review to summarize current serological studies in patients with RCD. Results of the studies reflect several systemic physiological changes in patients with RCD, which may prove helpful to better understand the complex pathology of RCD. In addition, the results also indicate the possibility of using serological tests in order to evaluate RCD; however, further longitudinal studies are required.

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Section: Discussionsupporting

confidence: 84%

The Usefulness of Serological Inflammatory Markers in Patients with Rotator Cuff Disease—A Systematic Review

Leung

Ngai

2022

Medicina

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“…Considering shoulder pain may be associated with infection, immune ( 16 ), diabetes mellitus ( 34 ) and bone metabolism ( 14 , 35 ), we collected related routine blood examination data, including leukocyte count, percentage of neutrophils, C-reactive protein (CRP), serum amyloid protein A (SAA), erythrocyte sedimentation rate (ESR), Vitamin D3, glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2-h postprandial plasma glucose (P2hPG) ( 28 ) to test their relationship with shoulder pain. Some patients underwent shoulder joint ultrasonography during hospitalization to assess the long head of biceps tendon, supraspinatus tendon, and subacrominal-subdeltoid (SA-SD) bursae of both shoulders, which helped to analyze the cause of shoulder pain.…”

Section: Methodsmentioning

confidence: 99%

“…Neurological factors include soft paralysis ( 9 ), spasm, brachial plexus injury, complex regional pain syndrome (CRPS) ( 10 ), central sensitization ( 11 ), paresthesia ( 12 ), unilateral neglect, etc. Recent studies have found that other factors, such as diabetes mellitus ( 13 ), vitamin D3 deficiency ( 14 ), psychology ( 15 ) and immunity ( 16 ), may also be associated with HSP.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, risk factor and outcome in middle-aged and elderly population affected by hemiplegic shoulder pain: An observational study

Yang

Cui

et al. 2023

Front. Neurol.

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BackgroundHemiplegic shoulder pain is the most common complication after stroke. It usually occurs during the critical period of stroke recovery and hinders the rehabilitation of upper extremity motor function. However, there are few studies on the risk factors, the development and prognosis of shoulder pain after stroke.ObjectivesThis study aimed to observe the prevalence of post-stroke shoulder pain in the middle-aged and elderly population, find out the risk factors for post-stroke shoulder pain, and explore its effect on stroke outcome.MethodsEligible patients with hemiplegic shoulder pain in the rehabilitation unit were recruited and followed up at 2 and 4 months. The basic clinical information including age, gender, hypertension and atrial fibrillation history, stroke types, stroke location was recorded. Range of motion for shoulder, glenohumeral subluxation, muscle tension, activity of daily living of upper limb were measured. Data from blood test and shoulder ultrasonography were collected.Results480 stroke patients were screened within 1 year, and 239 patients were included in the statistical analysis. The prevalence of hemiplegic shoulder pain was 55.6% (133/239) at admission, 59.4% (142/239) after 2 months, and 55.1% (130/236) after 4 months. We found that shoulder pain was more likely to occur in women, patients with large-area stroke, increased tension of biceps brachii or triceps brachii, subluxation and limited passive range of motion of the shoulder. And the ability of daily living of patients with shoulder pain was significantly lower than that of patients without shoulder pain. Shoulder ultrasonography showed that the most common lesion in patients with shoulder pain was supraspinatus tendon thickening, and the thickness of supraspinatus tendon in the hemiplegic side of patients with shoulder pain was significantly higher than that of unaffected side. In addition, the hospitalization rate of patients with shoulder pain after 2 months and 4 months was significantly higher than that without shoulder pain.ConclusionsHemiplegic shoulder pain has a high prevalence and can last for several months. Multiple risk factors are involved. Moreover, hemiplegic shoulder pain affects the readmission rate of patients. Therefore, we should pay more attention to this problem in our clinical work. The application of various means to relieve shoulder pain will be conducive to the recovery of upper limb motor function and shorten the in-hospital rehabilitation time.

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“…tendon integrity (13). Chi et al found that Vitamin B12, vitamin D and angiopoietin are significantly reduced in tendon disorders, which may contribute to a better understanding of the complex pathology of tendon disorders (54).…”

Section: B Amentioning

confidence: 99%

“…In a mouse model, vitamin D (VitD) prevented local decrease in bone mineral density (increased roughness of the proximal humerus) and improved rotator cuff tendon healing (12). Low serum vitamin B12 levels are associated with degenerative rotator cuff tear (13). In addition, leucine ameliorated tenotomy-induced muscle atrophy by inhibiting autophagy and possibly activating the PI3K/AKT/mTOR pathway in rotator cuff injury (14).…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D on rotator cuff tear with osteoporosis

Liu

Li²,

Zhang³

et al. 2022

Front. Endocrinol.

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BackgroundsOsteoporosis (OP) is an important risk factor for rotator cuff tears (RCTs). However, the relationship and mechanism between rotator cuff injury and osteoporosis are unclear. Therefore, to investigate association between rotator cuff injury and osteoporosis, and find clinical characteristics, bone mineral density, bone metabolism markers, and nutrient levels in rotator cuff injury patients with or without osteoporosis.MethodsOne hundred and four cases of patients (RCTs, n=32; RCTs-OP, n=72) who underwent rotator cuff injury and need arthroscopic rotator cuff repair between June 2021 and February 2022, along with the diagnosis of osteoporosis were identified from the dual-energy X-ray bone density screening(DXA). The outcome measure includes clinical characteristics, bone mineral density, bone metabolism markers, vitamins, and amino acids. Multivariable logistic regression analysis was applied to build a predicting model incorporating the feature selected in the least absolute shrinkage and selection operator regression model. Discrimination, calibration, and clinical usefulness of the predicting model were assessed using the C-index, calibration plot, and decision curve analysis. Internal validation was assessed using bootstrapping validation.ResultsOP with RCTs has a lower level of in 25-vitD, osteocalcin (OCN), serum Ca2+, ornithine, diaminocaproic_acid but the high level of Vitamin_B12, PTH, Vitamin_D3,γ_aminobutyric_acid, Vitamin_C and Vitamin_E than RCTs patients without OP. Predictors contained in the prediction nomogram included lumber T score, femur T score, Niacin_B3, and vitamin D, reflecting the combined effect of vitamins on RCTs-related OP progression. The model has good discriminative ability with a C-index of 0.938(95% CI:-1.83-1.39) and good scaling ability. The high C-index value of 0.95 is still achievable with range validation. Analysis of decision curves showed that non-adherence is clinically useful when intervention decisions are at the 14% probability limit of non-adherence.ConclusionThis study supports the hypothesis that lumber T score, femur T score, Niacin_B3, and Vitamin D are valuable prognostic biomarkers on RCTs related OP progression.What is known about the subjectIt is found that vitamin D are valuable prognostic biomarkers, reflecting the combined effect of vitamins on RCTs related OP progression.What this study adds to existing knowledgeThese findings also highlight that nutrients condition such as vitamins and amino acids of patients provide a new understanding of the development of RCTs.

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Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

Cited by 8 publications

References 36 publications

The Usefulness of Serological Inflammatory Markers in Patients with Rotator Cuff Disease—A Systematic Review

The Usefulness of Serological Inflammatory Markers in Patients with Rotator Cuff Disease—A Systematic Review

Prevalence, risk factor and outcome in middle-aged and elderly population affected by hemiplegic shoulder pain: An observational study

The role of vitamin D on rotator cuff tear with osteoporosis

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