Low Serum Vitamin E Level Associated with Low Hand Grip Strength in Community-Dwelling Adults: Korean National Health and Nutrition Examination Survey (KNHANES VII) 2016–2018

Kim, Yong-Jae; Shin, Sungjae; Hong, Namki; Rhee, Yumie

doi:10.3390/nu13051598

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…Micronutrients are critical for physiological functions of human being, and recent studies have found potential associations between micronutrients and muscle performance in elderly individuals (7,8). The associations between disturbances of several serum micronutrients (calcium, magnesium, selenium, copper, iron, zinc, Vitamin A, Vitamin B12, Vitamin D, and Vitamin E) and sarcopenia have been identified in previous observational studies, but the findings are controversial (6,(9)(10)(11)(12)(13)(14)(15)(16). Besides, given the observational design of these studies, the causal relationships between the levels of aforementioned serum micronutrients and the risk of sarcopenia remained unknown to a large extent.…”

Section: Introductionmentioning

confidence: 99%

Causal Relationship of Genetically Predicted Serum Micronutrients Levels With Sarcopenia: A Mendelian Randomization Study

Sha

et al. 2022

Front. Nutr.

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ObjectivesPrevious observational studies have suggested associations between concentrations of several circulating micronutrients and sarcopenia. However, the causality inferred from those studies was subjected to residual confounding and reverse causation. Therefore, we aimed to examine the causal effects of the levels of genetically predicted serum micronutrients on sarcopenia.MethodsSingle nucleotide polymorphisms (SNPs) were chosen from large-scale genome-wide association studies of participants only with European descent and were used as genetic instruments for the levels of 10 serum micronutrients (calcium, magnesium, selenium, copper, iron, zinc, Vitamin A, Vitamin B12, Vitamin D, and Vitamin E). Sarcopenia was defined by referencing to the 2019 definition given by the European Working Group on Sarcopenia in Older People (EWGSOP). A two-sample Mendelian randomization (MR) analysis was carried out to examine the associations between the levels of genetically predicted serum micronutrients and the risk of sarcopenia. Then, sensitivity analyses (including weighted median, MR-Egger and leave-one-out sensitivity analyses) were performed to evaluate the robustness of study findings. The estimates were presented as odds ratio (OR) with their 95% confidence intervals (CIs) per one standard deviation (SD) increase in the exposures.ResultsA total of 378,635 UK Biobank participants, including 572 participants who were identified with sarcopenia, were included in this study. The iron status was shown to have a clear effect on the risk of sarcopenia based on MR analyses. The per one SD increment in the genetically-determined serum iron level corresponded to a 53% increase in the risk of sarcopenia (OR = 1.53, 95% CI: 1.31–1.78, P = 0.001). The exclusion of SNPs of the circulating iron level (i.e., rs1799945 SNP, rs1800562 SNP or rs855791 SNP) did not attenuate the magnitude of the signal in MR analysis. There was little evidence supporting the associations between other remaining micronutrients and sarcopenia.ConclusionsAn increased risk of sarcopenia was observed with a genetically higher concentration of iron, suggesting that iron may play a role in the occurrence or development of sarcopenia.

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Section: Introductionmentioning

confidence: 99%

Causal Relationship of Genetically Predicted Serum Micronutrients Levels With Sarcopenia: A Mendelian Randomization Study

Sha

et al. 2022

Front. Nutr.

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“…However, we did not find any RCTs in Asia that directly evaluated vitamin E supplementation in terms of muscle health outcomes. Two cross‐sectional studies examined serum levels and dietary vitamin E but provided inconclusive evidence for vitamin E supplementation 86,87 . Therefore, evidence to support a role of vitamin supplementation in Asian studies was only found for vitamin D. Please see Table 1, Consensus Statement 8.…”

Section: Nutritional Supplementationmentioning

confidence: 99%

“…Two cross-sectional studies examined serum levels and dietary vitamin E but provided inconclusive evidence for vitamin E supplementation. 86,87 Therefore, evidence to support a role of vitamin supplementation in Asian studies was only found for vitamin D. Please see…”

Section: Vitaminsmentioning

confidence: 99%

“…One relatively easy test to perform is rhe determination of CC, which is the maximum value measured with a non‐elastic tape on both calves or a dominant or non‐dominant calf as specified and displays moderate‐to‐high sensitivity (73–92%) and specificity (50–88%) in detecting sarcopenia or low skeletal muscle mass 86,95–97 . In 2019, the AWGS recommended CC as a screening tool for sarcopenia in the community, using a cut‐off of <34 cm for males and <33 cm for females 4 .…”

Section: Outcomes and Assessmentsmentioning

confidence: 99%

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Roles of nutrition in muscle health of community‐dwelling older adults: evidence‐based expert consensus from Asian Working Group for Sarcopenia

Chen

Arai

Assantachai

et al. 2022

J cachexia sarcopenia muscle

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General muscle health declines with age, and in particular, sarcopenia-defined as progressive loss of muscle mass and strength/physical performance-is a growing issue in Asia with a rising population of community-dwelling older adults. Several guidelines have addressed early identification of sarcopenia and management, and although nutrition is central to treatment of sarcopenia, there are currently few guidelines that have examined this specifically in the Asian population. Therefore, the Asian Working Group for Sarcopenia established a special interest group (SIG) comprising seven experts across Asia and one from Australia, to develop an evidence-based expert consensus. A systematic literature search was conducted using MEDLINE on the topic of muscle health, from 2016 (inclusive) to July 2021, in Asia or with relevance to healthy, Asian community-dwelling older adults (≥60 years old). Several key topics were identified:(1) nutritional status: malnutrition and screening; (2) diet and dietary factors; (3) nutritional supplementation; (4) lifestyle interventions plus nutrition; and (5) outcomes and assessment. Clinical questions were developed around these topics, leading to 14 consensus statements. Consensus was achieved using the modified Delphi method with two rounds of voting. Moreover, the consensus addressed the impacts of COVID-19 on nutrition, muscle health, and sarcopenia in Asia. These statements encompass clinical expertise and knowledge across Asia and are aligned with findings in the current literature, to provide a practical framework for addressing muscle health in the community, with the overall aim to encourage and facilitate broader access to equitable care for this target population.

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“…Additionally, higher vitamin E levels are related to handgrip strength in Korean young adults (≤40 years) but not in older adults (40 years) [ 10 ]. However, other studies using Korean adults showed an association between vitamin E and handgrip strength in those aged 50 years and older [ 11 ]. Small group studies have shown that folic acid affects handgrip strength [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 96%

Folic Acid Is Related to Muscle Strength and Vitamin A Is Related to Health-Related Quality of Life: Results of the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018)

Lee¹,

Jung

2021

Nutrients

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This study investigated how folic acid affects muscle strength and the effects of vitamin A on quality of life in adults. Baseline data from the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018) was used to find 6112 adults (ages 19–80) meeting study criteria. The participants were divided into three groups: young adults (ages 19–39), middle-aged (ages 40–64), and elderly (≥65 years). Muscle strength was measured using a digital grip strength dynamometer. The EuroQol five-dimension questionnaire measured quality of life. Associations were assessed using multivariate regression and logistic regression. Vitamins and handgrip strength were divided into low and high groups based on the mean. Although vitamin A and folate levels were related to handgrip strength in all subjects, regression demonstrated a significant association between folate and handgrip strength in the elderly. The odds ratios (OR) of higher handgrip strength were statistically significant for elderly participants with high levels of folate compared to those with low levels (OR: 1.55). Vitamin A was associated with quality of life, especially in the self-care dimension for the elderly. Further longitudinal research is needed to examine the relationship between vitamins and muscle strength, as well as vitamins and quality of life.

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Low Serum Vitamin E Level Associated with Low Hand Grip Strength in Community-Dwelling Adults: Korean National Health and Nutrition Examination Survey (KNHANES VII) 2016–2018

Cited by 10 publications

References 41 publications

Causal Relationship of Genetically Predicted Serum Micronutrients Levels With Sarcopenia: A Mendelian Randomization Study

Causal Relationship of Genetically Predicted Serum Micronutrients Levels With Sarcopenia: A Mendelian Randomization Study

Roles of nutrition in muscle health of community‐dwelling older adults: evidence‐based expert consensus from Asian Working Group for Sarcopenia

Folic Acid Is Related to Muscle Strength and Vitamin A Is Related to Health-Related Quality of Life: Results of the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018)

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