Low-temperature optothermal nanotweezers

Zhou, Jianxing; Dai, Xiaoqi; Peng, Yuhang; Zhong, Yili; Ho, Ho-Pui; Shao, Yufeng; Gao, Bruce Z.; Qu, Junle; Chen, Jiajie

doi:10.1007/s12274-023-5659-1

Cited by 16 publications

(4 citation statements)

References 42 publications

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“…Compared to other SPR methodologies reported in the literature for miRNA detection (Table S4), the LOD attained a relatively low level. The proposed PI-SPR aptasensor can be applied to different application scenarios and is highly compatible with other optothermal or temperature control methods. , In our future endeavors, we will also prioritize the development of a more sensitive PI-SPR aptamer sensing system with a lower detection limit and shorter response time by integrating with active sample manipulation systems.…”

Section: Discussionmentioning

confidence: 99%

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Liu,

Wang,

Huang

et al. 2024

Anal. Chem.

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MicroRNAs (miRNAs) are novel tumor biomarkers owing to their important physiological functions in cell communication and the progression of multiple diseases. Due to the small molecular weight, short sequence length, and low concentration levels of miRNA, miRNA detection presents substantial challenges, requiring the advancement of more refined and sensitive techniques. There is an urgent demand for the development of a rapid, user-friendly, and sensitive miRNA analysis method. Here, we developed an enhanced biotin–streptavidin dual-mode phase imaging surface plasmon resonance (PI-SPR) aptasensor for sensitive and rapid detection of miRNA. Initially, we evaluated the linear sensing range for miRNA detection across two distinct sensing modalities and investigated the physical factors that influence the sensing signal in the aptamer-miRNA interaction within the PI-SPR aptasensor. Then, an enhanced biotin–streptavidin amplification strategy was introduced in the PI-SPR aptasensor, which effectively reduced the nonspecific adsorption by 20% and improved the limit of detection by 548 times. Furthermore, we have produced three types of tumor marker chips, which utilize the rapid sensing mode (less than 2 min) of PI-SPR aptasensor to achieve simultaneous detection of multiple miRNA markers in the serum from clinical cancer patients. This work not only developed a new approach to detect miRNA in different application scenarios but also provided a new reference for the application of the biotin–streptavidin amplification system in the detection of other small biomolecules.

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Section: Discussionmentioning

confidence: 99%

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Liu,

Wang,

Huang

et al. 2024

Anal. Chem.

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“…[86,87] This implies that they can also survive under the conditions of DSV mode, which reaches a maximum temperature of 42 °C (0.6 mW). Despite its current limitations, we believe that with further refinements, such as integrating temperature control technique [56] or introducing electronic fields, [14][15][16] the inherent biocompatibility and adaptability of the HAONT scheme will enable it to become a versatile nano-manipulation tool suitable for various applications in synthetic biology, colloidal science, nanotechnology, and biomedical research.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, one typically needs to design specific trapping strategies tailored for different types of particles, such as biological or metal nanoparticles. [22,34,[53][54][55][56] In addressing these challenges, by incorporating diffusiophoresis with the thermo-osmotic flow, that is, a slip flow parallel to the solid-liquid interface induced by the excess enthalpy in the boundary layer, [57] we developed highly-adaptable optothermal nanotweezers (HAONT), enabling nanoparticle manipulation with sub-10 nm trapping accuracy without surface modification. This technique operates effectively on a wide range of nanoparticles, encompassing organic, inorganic, and biological entities, such as polystyrene spheres (PSs), mesoporous silica nanoparticles (MSNs), quantum dots (QD), metal nanoparticles (ranging from 5 to 200 nm), exosomes, viruses (including COVID-19), and bacteria (Escherichia coli cell).…”

Section: Introductionmentioning

confidence: 99%

Highly‐Adaptable Optothermal Nanotweezers for Trapping, Sorting, and Assembling across Diverse Nanoparticles

Chen,

Zhou,

Peng

et al. 2023

Advanced Materials

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Optical manipulation of various kinds of nanoparticles is vital in biomedical engineering. However, classical optical approaches demand higher laser power and are constrained by diffraction limits, necessitating tailored trapping schemes for specific nanoparticles. They lack a universal and biocompatible tool to manipulate nanoparticles of diverse sizes, charges, and materials. Through precise modulation of diffusiophoresis and thermo‐osmotic flows in the boundary layer of an optothermal‐responsive gold film, highly adaptable optothermal nanotweezers (HAONTs) capable of manipulating a single nanoparticle as small as sub‐10 nm are designed. Additionally, a novel optothermal doughnut‐shaped vortex (DSV) trapping strategy is introduced, enabling a new mode of physical interaction between cells and nanoparticles. Furthermore, this versatile approach allows for the manipulation of nanoparticles in organic, inorganic, and biological forms. It also offers versatile function modes such as trapping, sorting, and assembling of nanoparticles. It is believed that this approach holds the potential to be a valuable tool in fields such as synthetic biology, optofluidics, nanophotonics, and colloidal science.

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“…Optical tweezers, proposed by Ashkin in 1986, offer a contactless, non-invasive and high-precision technique for trapping and manipulating tiny entities in three-dimensional space [1]. This breakthrough has catalyzed extensive research efforts in the realms of biology, physics, and micro-nano optics [2][3][4][5][6][7][8]. Generally, the accurate trapping of mirco-nano particles usually relies on the gradient and scattering forces exerted by light beams, with the former linked to the intensity gradient of light and the latter associated with the Poynting vector [9].…”

Section: Introductionmentioning

confidence: 99%

Switchable optical trapping and manipulation enabled by polarization-modulated multifunctional phase-change metasurfaces

Xu,

Tian,

et al. 2024

J. Phys. D: Appl. Phys.

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Optical trapping, a cutting-edge methodology, is pivotal for contactlessly controlling and exploring microscopic objects. However, it encounters formidable challenges such as multiparticle trapping, flexible control, and seamless integration. Here, we employ a polarization-modulated multi-foci technique for versatile nanoparticle trapping using multifunctional metasurfaces relying on geometric phase. Numerical simulations demonstrate the generation of two focused spots with orthogonal polarization distributions through our metasurfaces when illuminated with linearly polarized light, with their polarization distributions be interchanged by orthogonally switching the incident polarizations. We extend this design to an array of multi-foci metasurface tweezers modulated by polarization, highlighting the versatility and robustness of our approach. Furthermore, we demonstrate the simultaneous generation of two distinct focusing cylindrical vector beams using a monolayer metasurface, showcasing the two vector beams possess the interchange ability of their polarization distributions. By leveraging the Maxwell stress tensor, we assess the distinct contributions of the focused beams to longitudinal and transverse optical forces on SiO2 spheres, validating diverse trapping and manipulation behaviors for nanoparticles with the proposed metasurface designs. By manipulating the phase states of Sb2S3 nanopillars, binary-switchable optical trapping and manipulation are facilitated for for all proposed metasurface tweezers. Our work underscores the efficacy of polarization-modulation multifunctional metasurface tweezers in consolidating multiple trapping tasks into a single device, paving the way for innovative lab-on-a-chip optical trapping applications in biophysics, nanotechnology, and photonics.

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Low-temperature optothermal nanotweezers

Cited by 16 publications

References 42 publications

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Advancing MicroRNA Detection: Enhanced Biotin–Streptavidin Dual-Mode Phase Imaging Surface Plasmon Resonance Aptasensor

Highly‐Adaptable Optothermal Nanotweezers for Trapping, Sorting, and Assembling across Diverse Nanoparticles

Switchable optical trapping and manipulation enabled by polarization-modulated multifunctional phase-change metasurfaces

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