Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients With Type 2 Diabetes

Abstract

Low T is associated with more advanced atherosclerotic disease markers in middle-aged patients with T2D.

Testosterone, dihydrotestosterone and estradiol are differentially associated with carotid intima-media thickness and the presence of carotid plaque in men with and without coronary artery disease

“…Our findings in community-dwelling men are consistent with several smaller studies of middle-aged men with symptomatic low T concentrations [10], men with Type 2 diabetes [12,26], in overweight and obese glucose tolerant young men [27], and in healthy middle-aged men [28]. These studies showed an inverse association between T [10,12], free T [26,27] and bioavailable T [28] with CIMT.…”

“…However, these associations between T and preclinical carotid atherosclerosis are not present in men with established premature CAD. Given the heterogeneity of previously studied cohorts, our results using LC-MS in two distinct and carefully phenotyped cohorts of men of comparable age may explain previous inconsistencies in the literature [10][11][12][13][14][15][26][27][28].…”

“…These studies showed an inverse association between T [10,12], free T [26,27] and bioavailable T [28] with CIMT. Of these studies, two did not report on the proportion of men with CVD [26,28] while the rest excluded men with CVD [10,12,27]. In contrast to our findings, a study by van den Beld et al in older men reported inverse associations of T with CIMT which were comparable for men with or without CVD [29].…”

“…Studies that have examined the relationship between T with CIMT and carotid plaque in middle-aged men have shown inconsistent results. Cross sectional studies have demonstrated an inverse association between T with CIMT and carotid plaque [10][11][12][13][14], while others have shown no association [15]. One longitudinal study demonstrated no association between T and progression of CIMT or plaque area, while another showed an inverse relationship [13,16].…”

To Study the Relationship Between Serum Testosterone, HSCRP and Carotid Atherosclerosis in Men From Northwest Punjab With Type 2 Diabetes Mellitus

“…The study of Schneider HJ et al (12) concluded that obesity, metabolic syndrome, and acute inflammation was associated with hypogonadal testosterone levels. In the study by Javier M. F. et al, (13) hsCRP levels were 2.74 +/-1.37 mg/dL in low serum T group and 0.89 +/-0.93 mg/dL in the normal Serum T group.…”