Low time resolution in schizophrenia

Foucher, Jack; Lacambre, M.; Pham, Bich‐Thuy; Giersch, Anne; Elliott, Mark A.

doi:10.1016/j.schres.2007.08.013

Cited by 114 publications

(62 citation statements)

References 41 publications

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“…Additionally, group differences were only found with synchronous presentation of auditory and visual stimuli. This result is contrary to our hypothesis that group differences would be obtained during the asynchronous condition due to differences in sensitivity to the temporal integration window (differences in the response to asynchrony of the AV stimuli—Foucher et al, 2007). This may indicate group differences in how gamma-band oscillations bind auditory and visual stimuli.…”

Section: Discussioncontrasting

confidence: 99%

“…Therefore, we hypothesized that patients would show greater deficits in gamma-band power in response to peripheral (dorsal stream) visual stimuli relative to central (ventral stream) visual stimuli. Furthermore, multisensory studies have demonstrated that patients with schizophrenia have a wider window of integration than healthy controls when the stimuli are offset in time (Foucher et al, 2007), suggesting that HC can differentiate asynchronous stimuli with smaller delays between auditory and visual stimuli than SP. In summary, we hypothesized that SP and HC would show differential patterns of event-related gamma-band activity and these differences would vary by condition (unisensory/multisensory, near/far, and synchronous/asynchronous).…”

Section: Introductionmentioning

confidence: 99%

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Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Stone

Coffman

Bustillo

et al. 2014

Front. Hum. Neurosci.

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Deficits in auditory and visual unisensory responses are well documented in patients with schizophrenia; however, potential abnormalities elicited from multisensory audio-visual stimuli are less understood. Further, schizophrenia patients have shown abnormal patterns in task-related and task-independent oscillatory brain activity, particularly in the gamma frequency band. We examined oscillatory responses to basic unisensory and multisensory stimuli in schizophrenia patients (N = 46) and healthy controls (N = 57) using magnetoencephalography (MEG). Time-frequency decomposition was performed to determine regions of significant changes in gamma band power by group in response to unisensory and multisensory stimuli relative to baseline levels. Results showed significant behavioral differences between groups in response to unisensory and multisensory stimuli. In addition, time-frequency analysis revealed significant decreases and increases in gamma-band power in schizophrenia patients relative to healthy controls, which emerged both early and late over both sensory and frontal regions in response to unisensory and multisensory stimuli. Unisensory gamma-band power predicted multisensory gamma-band power differently by group. Furthermore, gamma-band power in these regions predicted performance in select measures of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) test battery differently by group. These results reveal a unique pattern of task-related gamma-band power in schizophrenia patients relative to controls that may indicate reduced inhibition in combination with impaired oscillatory mechanisms in patients with schizophrenia.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Stone

Coffman

Bustillo

et al. 2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

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“…Psychometric functions (PFs) were sed correction after Elliott et al (2007): PFs were overall steeper (see Figure 1) and differed significantly between groups for both SB S and SB A conditions (all t > 2.0, p < .05), except for SB s between FEP and CSZ groups (t = w on those studies to show FEP patients with various diagnoses also had significantly elevated thresholds rel ls. In fact, the major finding in this study is that irrespective of diagnosis, patients having recently experienced a psychotic episode for the first time will require longer SOAs than controls and similar SOAs to st premask was found to be non-significant ( (2,56) = .865, = .427).…”

Section: Hreshold Calculationsmentioning

confidence: 95%

Low-level temporal coding impairments in psychosis: Preliminary findings and recommendations for further studies.

Schmidt

Mcfarland²,

Ahmed³

et al. 2011

Journal of Abnormal Psychology

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The authors investigated whether difficulties with temporal event coding, previously reported in patients with schizophrenia, are already present during first-episode psychosis (FEP). In this experiment, the subjective judgments of the simultaneity of visually presented stimuli were compared between 11 healthy controls, 9 patients with chronic schizophrenia (CSZ), and a sample of 11 FEP patients. Participants were asked to indicate whether 2 vertical bars appeared at the same time or at different times on a computer monitor. CSZ patients' thresholds were elevated, and the FEP sample showed higher thresholds relative to controls. Although preliminary, these findings indicate a generalized disturbance in event-structure coding at early stages of psychosis and question the specificity of its disturbance. Considering the proposed relationship between event-structure coding and the experience of time in general, this study recommends that future studies refocus on psychosis in general, rather than on schizophrenia as a particular case of abnormal temporal processing. In addition, it is suggested that the relevant psychopathology will be best determined by means of a comprehensive analysis of low-level temporal coding performance in different types of psychosis.

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“…Some studies have found MSI deficits in patients when using complex stimuli, such as speech (de Gelder, Vroomen, Annen, Masthof, & Hodiamont, 2003; Pearl et al, 2009; Szycik et al, 2009) or socially relevant stimuli (e.g., facial expression and prosody) (de Gelder et al, 2005; de Jong, Hodiamont, Van den Stock, & de Gelder, 2009; Fiszdon & Bell, 2010). Other studies have shown that when multisensory stimuli are synchronous, MSI is intact in patients; however, when there is asynchrony between multisensory stimuli patients show deficits (e.g., Foucher, Lacambre, Pham, Giersch, & Elliott, 2007; Martin, Giersch, Huron, & van Wassenhove, 2013). Tschacher and Bergomi (2011) and Surguladze et al (2001) found evidence of intact MSI in schizophrenia patients, though these patterns were affected by levels of psychotic symptoms.…”

Section: Introductionmentioning

confidence: 95%

Multisensory integration in schizophrenia: a behavioural and event-related potential study

Wynn

Jahshan

Green

2014

Cognitive Neuropsychiatry

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Introduction Successful processing of multisensory stimuli increases the likelihood of detection or identification of salient, biologically significant events faster and more efficiently than unisensory inputs. Schizophrenia patients (SZ) show deficits in unisensory processing, but it is unclear whether impairments are seen to multisensory stimuli, a process known as multisensory integration (MSI). We used behavioral and event-related potential (ERP) measures to examine MSI in SZ and healthy controls (HC). Methods Thirty-three SZ and 30 HC completed a target detection task with unisensory and multisensory stimuli. Reaction times (RT) were measured while EEG was recorded. Two auditory (N100, P200) and visual (P100, N160) ERPs were examined. MSI was analyzed in terms of violations of RT to the race model, and by comparing ERPs in the MSI condition to the sum of the unisensory ERPs. Results Both groups showed faster RT in MSI compared to unisensory conditions. SZ had nonsignificantly fewer violations of the race model compared to HC. SZ had significantly smaller amplitudes to unisensory visual N160 and auditory P100 relative to HC; there were no significant group differences on any ERP measure of MSI. Conclusions SZ showed relatively intact MSI with subtle (nonsignificant) differences at the neural and behavioral levels compared to HC. Our results suggest that neural processes associated with MSI are not an additional source of impairment in SZ.

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Low time resolution in schizophrenia

Cited by 114 publications

References 41 publications

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Low-level temporal coding impairments in psychosis: Preliminary findings and recommendations for further studies.

Multisensory integration in schizophrenia: a behavioural and event-related potential study

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