Low Value of [<sup>18</sup>F]-Fluoro-2-Deoxy-<scp>d</scp>-Glucose Positron Emission Tomography in Primary Staging of Early-Stage Cervical Cancer Before Radical Hysterectomy

Chou, Hung Hsueh; Chang, Ting Chang; Yen, Tzu Chen; Ng, Koon Kwan; Hsueh, Swei; Ya, Shih; Chang, Chee Jen; Huang, Hsuan-Rong; Chao, Angel; Wu, Ting-Jung; Jung, Shih Ming; Wu, Yen Ching; Lin, Cheng Tao; Huang, Kuo‐Lun; Lai, Chyong‐Huey

doi:10.1200/jco.2005.03.5964

Cited by 131 publications

(54 citation statements)

References 30 publications

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“…In our institution, the tumor extent is assessed preoperatively by magnetic resonance imaging and only those patients with (i) stage IA2-IIA; (ii) nonbulky SC (<4 cm) without deep cervical stromal invasion ( 2/3) and parametrial extension, or AC/ASC (of any size) and (iii) free of pelvic node metastasis undergo primary radical surgery. 36 The prognosis of subclinical micrometastasis of pelvic nodes in early-stage cervical cancer is not well defined.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

Chao¹,

Wang²,

Lee³

et al. 2006

Intl Journal of Cancer

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In an attempt to understand the molecular mechanisms for the different clinical features between adenocarcinoma/adenosquamous carcinoma (AC/ASC) and squamous carcinoma (SC) of the uterine cervix, we analyzed gene expression profiles of different histological subtypes of cervical cancer. Cancer specimens and the surrounding normal tissue counterparts were separately collected from cervical cancer patients undergoing type III radical hysterectomy. Paired total RNA (cancer and normal tissues) was isolated and analyzed with cDNA microarrays containing duplicate spots of 7 334 sequence-verified human cDNA clones. Selected differentially expressed genes specific for AC or SC were further verified using real-time quantitative polymerase chain reaction (RTQ-PCR) and immunohistochemistry. Genes, including CEACAM5, TACSTD1, S100P and MSLN were upregulated in AC. Contrarily, genes involved in epidermal differentiation complex such as S100A9 and ANXA8 were upregulated in SC. Cross-validation of the results using an independent but comparable group of patients with known long-term outcomes (n 5 63, median follow-up 70.3 months; range, 4-208 months) showed that the correlation between the selected 6 differentially expressed genes and histology was highly significant. CEACAM5 (p < 0.0001) and TACSTD1 (p 5 0.009) were significant prognostic factors by multivariate Cox proportional hazards regression analysis. The combination of cDNA microarray, RTQ-PCR and immunohistochemical results of this study showed that it is possible to define different gene profiles for AC and SC. Moreover, TACSTD1 expression may be a novel poor prognostic factor. ' 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

Chao¹,

Wang²,

Lee³

et al. 2006

Intl Journal of Cancer

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“…22 Although PET has revealed 85.7% sensitivity, 94.4% specificity, 92% accuracy in locally advanced cervical cancer, 23 sensitivity is limited to 10% (1/10) in cases without LN enlargement on the MRI. 24 Therefore, laparoscopic surgical staging may be a valid substitute to overcome such inaccuracies. Treatment plans for concurrent chemoradiotherapy are determined not by surgical LN staging but such inaccurate imaging modalities.…”

Section: Discussionmentioning

confidence: 99%

Experiences of pretreatment laparoscopic surgical staging in patients with locally advanced cervical cancer: results of a prospective study

et al. 2008

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Objective: To prospectively evaluate the feasibility, safety, and survival of laparoscopic surgical staging in patients with locally advanced cervical cancer. Methods: From Oct 2001 to Jul 2006, a total of 83 consecutive patients were eligible for inclusion and underwent laparoscopic surgical staging. Results: Three patients with intraoperative great vessel injury and 1 patient in whom the colpotomizer was unable to be inserted were excluded. Laparoscopic surgical staging was feasible in 95.2% (79/83). Immediate postoperative complications were noted in 12 (15.2%) patients. Prolonged complications directly related to operative procedures numbered 2 (2.5%), and were trocar site metastases. The mean time from surgery to the start of radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) was 11 (5-35) days. All patients tolerated the treatment well and completed scheduled RT or CCRT without disruption of treatment and additional admission. The rate of modification of the radiation field after surgical staging was 8.9% (7/79). Five-year progression-free survival and overall survival (OS) rates were 79% and 89%, respectively. The OS of patients with microscopic lymph node metastases, which were fully resected, were comparable to those of patients without lymph node metastasis. However, the OS of patients with macroscopic lymph node metastases that were fully resected were poorer compared with those of patients without lymph node metastasis. Conclusion: Pretreatment laparoscopic surgical staging is a feasible and safe treatment modality. However the survival benefit of debulking lymph nodes or full lymph node dissection is not clear.

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“…respectively [17]. The benefits gained are limited from additional PET when CT/MRI is negative at primary staging for early-stage cervical cancer.…”

Section: Role Of Pet For Primary Staging Is Controversial In Early-stmentioning

confidence: 99%

When and how often should PET scans be performed in the management of cervical cancer?

Lai

Yen

2010

Expert Review of Anticancer Therapy

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Low Value of [¹⁸F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography in Primary Staging of Early-Stage Cervical Cancer Before Radical Hysterectomy

Abstract: This study shows that dual-phase FDG-PET has little value in primary, nonbulky, stage IA2 to IIA and MRI-defined, LN-negative cervical cancer.

Cited by 131 publications

References 30 publications

Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

Experiences of pretreatment laparoscopic surgical staging in patients with locally advanced cervical cancer: results of a prospective study

When and how often should PET scans be performed in the management of cervical cancer?

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Low Value of [18F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography in Primary Staging of Early-Stage Cervical Cancer Before Radical Hysterectomy

Abstract: This study shows that dual-phase FDG-PET has little value in primary, nonbulky, stage IA2 to IIA and MRI-defined, LN-negative cervical cancer.

Cited by 131 publications

References 30 publications

Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

Experiences of pretreatment laparoscopic surgical staging in patients with locally advanced cervical cancer: results of a prospective study

When and how often should PET scans be performed in the management of cervical cancer?

Contact Info

Product

Resources

About

Low Value of [¹⁸F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography in Primary Staging of Early-Stage Cervical Cancer Before Radical Hysterectomy