The dynamics of Earth's D″ layer at the base of the mantle plays an essential role in Earth's thermal and chemical evolution. Mantle convection in D″ is thought to result in seismic anisotropy; therefore, observations of anisotropy may be used to infer lowermost mantle flow. However, the connections between mantle flow and seismic anisotropy in D″ remain ambiguous. Here, we calculate the present‐day mantle flow field in D″ using 3D global geodynamic models. We then compute strain, a measure of deformation, outside the two large‐low velocity provinces (LLVPs) and compare the distribution of strain with previous observations of anisotropy. We find that, on a global scale, D″ materials are advected toward the LLVPs. The strains of D″ materials generally increase with time along their paths toward the LLVPs and toward deeper depths, but regions far from LLVPs may develop relative high strain as well. Materials in D″ outside the LLVPs mostly undergo lateral stretching, with the stretching direction often aligning with mantle flow direction, especially in fast flow regions. In most models, the depth‐averaged strain in D″ is >0.5 outside the LLVPs, consistent with widespread observations of seismic anisotropy. Flow directions inferred from anisotropy observations often (but not always) align with predictions from geodynamic modeling calculations.