Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p < 0.05), a significantly higher rate of obesity (p < 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p < 0.05) and exposed to sun (p < 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

“…Vitamin D deficiency has been suggested to contribute to the pathogenesis of insulin resistance and PCOS [10]. Vitamin D deficiency, implicated in PCOS pathogenesis, was evident in our study, aligning with prior research [9,15,22]. However, discordant findings regarding vitamin D levels among PCOS subjects exist in the literature [10,11,20], underscoring the complexity of this relationship.…”

“…Furthermore, our study revealed significantly higher levels of TC, TG, and LDL-C in PCOS subjects compared to controls, consistent with previous research indicating dyslipidemia as a potential complication of PCOS [9,17,18]. The higher mean blood glucose in the PCOS group observed in this study reflects their elevated risk of hyperinsulinemia and diabetes mellitus [19], contrasting with the findings of Bindayel and Kim et al [15,20] but agreeing with the findings of Kharb et al [19] and Eftekhar et al [21]. This supports the suggestion that hyperinsulinemia may be linked to PCOS pathophysiology.…”

Molecular role of non-exonic variants in CALPAIN 10 gene in polycystic ovarian syndrome in Saudi women

“…Some studies dealt with the psychological burden among Saudi women with PCOS ( 35 , 36 ). Another study confirmed low vitamin D levels in women with PCOS in Saudi Arabia ( 30 ). Low levels of vitamin D, FSH, sex hormone-binding globulin, and estradiol were recorded in women with PCOS, together with high androgen, LH, TT, FBG, TC, and LDLc levels ( 37 ).…”

“…Hormonal imbalance and metabolic dysregulation underlie PCOS pathogenesis ( 30 ). This disease is also characterized by problematic follicular development.…”

Deficiencia de vitamina D y patologías ginecológicas de la mujer en edad reproductiva

“…No existe evidencia clara que indique la posible asociación entre concentraciones bajas de VitD y la patogénesis del SOPQ, especialmente en pacientes con peso normal (10,11) . Existe evidencia de correlaciones entre las concentraciones de VitD y valores de andrógenos, hormona luteinizante y foliculoestimulante (12) . Sin embargo, otras investigaciones no confirmaron estos hallazgos (13,14) .…”