Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis

Abstract

BackgroundCognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT.MethodsWe recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA). Subjects with a MoCA scores < 26 are considered as having mild cognitive impairment (MCI). Multivariate analysis was performed using logistic regression models.ResultsFifty-five HT patients (28.4%) were diagnosed as having MCI. Patients with MCI had significantly lower 25(OH)D levels when compared with patients without MCI (33.9 ± 6.2 vs. 44.3 ± 9.6 nmol/L, P < 0.001). Significant differences in 25(OH)D quartiles of HT patients were observed between the patients with MCI and the patients without MCI (P < 0.001). In multivariate analyses, serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT (OR 6.279, 95% CI 2.673–14.834, P < 0.001; OR 0.061, 95% CI 0.008–0.491, P = 0.009, respectively).ConclusionOur results demonstrate an important association between serum vitamin D levels and cognitive impairment in patients with HT.

The evaluation of Hashimoto's thyroiditis with event-related potentials and magnetic resonance spectroscopy and its relation to cognitive function

“…The clinical manifestations of autoimmune thyroiditis are not specific and are often low. However, many patients report numerous subjective complaints that have a significant impact on their quality of life 5 , 7 . In The Colorado Thyroid Disease Prevalence Study conducted in 2000, 18,750 people with compensated thyroid function were identified among 25,000 people in the general population, 114 patients with overt hypothyroidism and over 2300 patients with subclinical hypothyroidism 23 .…”

“…Subclinical hypothyroidism may have a similar but more subtle effect on cognitive function 6 . However, there are few reports on cognitive disorders in patients with HT with compensated thyroid function, in whom difficulties with memory, focusing attention, or slowing down of thinking are often observed 7 , 8 . The cause of these symptoms has not yet been clarified.…”

Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto’s Thyroiditis via Sponging miR125a-3p

“…Moreover, GO enrichment analysis suggested that circRNAs are involved in a variety of biological processes, such as vitamin D receptor and MAPK binding. In addition, it has been reported that low levels of vitamin D may be involved in the occurrence of HT 30, 31, 32. It has also been suggested that MRP14 takes part in the pathogenetic process of HT through regulating the MAPK signal pathway 33 .…”

Influence of collateral circulation on cerebral blood flow and frontal lobe cognitive function in patients with severe internal carotid artery stenosis

“…Patients with a single type of collateral circulation: anterior communicating artery (AcoA), posterior communicating artery (PcoA), or ophthalmic artery (OA) confirmed by DSA were selected. The exclusion criteria included: 1) dementia (Montreal Cognitive Assessment < 26) [14]; 2) disturbance of consciousness; 3) transient ischemic attack (TIA); 4) MRI showing cerebral infarction or other pathological brain diseases, such as hemorrhages, tumors, aneurysms and vascular anomalies; 5) inadequate temporal window in TCD examination; 6) concomitant stenosis in other arteries; or 7) color blindness or color weakness. According to the type of collateral circulation, patients were classified into three groups: AcoA group, PcoA group, and OA group.…”