Low vitamin D status among pregnant Latin American and Caribbean women with HIV Infection

Jao, Jennifer; Freimanis, Laura; Mussi-Pinhata, Marisa Márcia; Cohen, Rachel; Monteiro, Jacqueline Pontes; Cruz, Maria Letícia Santos; Sperling, Rhoda; Branch, Andrea D.; Siberry, George K.

doi:10.1016/j.ijgo.2015.01.017

Cited by 10 publications

(6 citation statements)

References 30 publications

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“… 17 However, the finding was lower than the results of studies done in India-92.63% 25 and 89.2%, 20 Michigan-95%, 26 and France-86%. 22 On the other hand, the result of the current study was higher than the finding of a study conducted in New York City-21.2%, 2 South-Central United States-64%, 3 Southern Australian-39%, 27 Italy-47%, 28 Latin American and Caribbean-65.7%, 29 Kazakhstan- 65.1%, 30 and Tanzania-52.8%. 31 Additionally, the figure is also higher in non-HIV subjects.…”

Section: Discussioncontrasting

confidence: 81%

Prevalence and Predictors of Hypovitaminosis D in Ethiopian HIV-Infected Adults

Belete¹,

Tefera²,

Getnet³

et al. 2021

HIV

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Background: Hypovitaminosis D is associated with bone fracture and cardiovascular disease in patients receiving antiretroviral therapy. Currently, there are few data on the magnitude of hypovitaminosis D in people living with HIV in Sub-Saharan country. Therefore, the present study determines the magnitude of hypovitaminosis D in people living with HIV and its associated factors in Ethiopia. Methods: A cross-sectional study was conducted among 171 adult people living with HIV at Debre Berhan Specialized Hospital. Serum vitamin D was measured. Multivariate logistic regression analysis and p-value <0.05 was used to identify the associated factors of hypovitaminosis D. Results: In the present study, the prevalence of hypovitaminosis D was 129/171 (75.4%), with 11/171 (6.4%) having vitamin D deficiency and 118/171 (69%) having vitamin D insufficiency. Female sex was significantly associated with hypovitaminosis D (AOR: 3.01, 95% CI = 1.381-6.561, P = 0.006). Conclusion:Our study found a high burden of hypovitaminosis D among adult people living with HIV on antiretroviral therapy. Female sex was associated with hypovitaminosis D.

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Section: Discussioncontrasting

confidence: 81%

Prevalence and Predictors of Hypovitaminosis D in Ethiopian HIV-Infected Adults

Belete¹,

Tefera²,

Getnet³

et al. 2021

HIV

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“…Great attention has been given to the field of vitamin D in HIV-infected patients over the last few years, and epidemiological data suggest that HIV-infected patients, also from different geographical locations, including Europe, American, and Australia have a high prevalence of vitamin D insufficiency [ 31 , 32 , 33 ]. In our cohort, the prevalence of insufficiency of vitamin D3 in HIV-infected patients was 50%, significantly higher compared to the control group (20%).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and the Relationship with Bone Fragility Fractures in HIV-Infected Patients: A Case Control Study

Atteritano

Mirarchi

Rullo

et al. 2018

IJMS

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HIV-infected patients show high risk of fracture. The aims of our study were to determine the prevalence of vertebral fractures (VFs) and their associations with vitamin D in HIV patients. 100 patients with HIV infection and 100 healthy age- and sex-matched controls were studied. Bone mineral density was measured by quantitative ultrasound at the non-dominant heel. Serum osteocalcin and C-terminal telopeptide of collagen type 1 served as bone turnover markers. Bone ultrasound measurements were significantly lower in patients compared with controls (Stiffness Index (SI): 80.58 ± 19.95% vs. 93.80 ± 7.10%, respectively, p < 0.001). VFs were found in 16 patients and in 2 controls. HIV patients with vertebral fractures showed lower stiffness index (SI) (70.75 ± 10.63 vs. 83.36 ± 16.19, respectively, p = 0.045) and lower vitamin D levels (16.20 ± 5.62 vs. 28.14 ± 11.94, respectively, p < 0.02). The majority of VFs (87.5%) were observed in HIV-infected patients with vitamin D insufficiency, and regression analysis showed that vitamin D insufficiency was significantly associated with vertebral fractures (OR 9.15; 95% CI 0.18–0.52, p < 0.04). VFs and are a frequent occurrence in HIV-infected patients and may be associated with vitamin D insufficiency.

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“…Special attention should be given to vitamin D status and its impact on bone metabolism in these patients. In our cohort, 87.6% of the patients had low levels of vitamin D. In recent years, a number of studies have suggested that patients living with HIV infection have a high prevalence of vitamin D deficit independently of their geographic origin [25][26][27], similar to findings in adults generally (HIV 70.3% compared with 79.1% of HIV-negative adults) [28]. In addition to its deleterious impact on patients with HIV infection, vitamin D deficiency is a well-established risk factor for bone disease within the general population [29].…”

Section: Discussionmentioning

confidence: 60%

Increased risk factors associated with lower BMD in antiretroviral-therapy–naïve HIV-infected adult male

et al. 2021

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Background Low BMD (bone mineral density) has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied in young HIV-infected men who have received no previous antiretroviral therapy. Methods A cross-sectional study of 245 naïve-HIV-infected men over 21 and under 50 years old who voluntary attended the Infectious Disease Division appointment in Hospital Fundación Jimenez Díaz in Madrid, from January 1st, 2014 to September 30th, 2017. All subjects underwent a baseline DXA scan (dual energy x-ray absorptiometry) performed prior to start antiretroviral treatment. Further, all patients who started treatment between May 1st and September 30th, 2017 were invited to participate in a substudy on bone mineral metabolism. All the information was collected through clinical history and complementary questionnaire. Results The mean age was 36.4 years, been 68% Caucasian, 29.3% Latin American and 2.7% African race. At the time of diagnosis, 91% of patients had stage-A (median CD4+ T-cell 481cells/μL, IQR, 320–659). 10% had a count below 200 CD4 cells/μL, and 40% had a CD4/CD8 cell-count-ratio below 0.4. Regarding lifestyle and risk factors, 14.1% presented underweight, 36.1% were not engage in any regular exercise, 51.9% were active smokers and 35.3% reported drug use. Low levels of vitamin D were seen in 87.6% of the study participants. Low BMD (Z-score <- 2.0) was found in 22.8% of the patients. It was only observed a significant association of Z-score in lumbar spine (LS) with CD8 and the CD4/CD8 ratio, and with alcohol for femoral neck (FN) measurement. Conclusions We find prevalence of increased bone involvement among naïve HIV-infected men under 50 years old. Further studies are necessary to evaluate if changes in actual guidelines are needed to assess BMD measurements in HIV-infected adult male patients under 50.

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Low vitamin D status among pregnant Latin American and Caribbean women with HIV Infection

Cited by 10 publications

References 30 publications

Prevalence and Predictors of Hypovitaminosis D in Ethiopian HIV-Infected Adults

Prevalence and Predictors of Hypovitaminosis D in Ethiopian HIV-Infected Adults

Vitamin D Status and the Relationship with Bone Fragility Fractures in HIV-Infected Patients: A Case Control Study

Increased risk factors associated with lower BMD in antiretroviral-therapy–naïve HIV-infected adult male

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