Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction

Binkley, Neil; Ramamurthy, Rekha; Krueger, Diane

doi:10.1016/j.rdc.2012.03.006

Cited by 35 publications

(30 citation statements)

References 111 publications

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“…2 Data include all vitamin D from foods, study supplements, and personal supplements, and include only the 37 participants who returned diet logs. 3 The baseline blood draw was in February and participants started taking study supplements (either 2,000 IU/d or 10,000 IU/wk) after that time point. 4 Participants in the no-study-supplements group took their own supplements, before and throughout the study.…”

Section: Resultsmentioning

confidence: 99%

“…Several reports suggest, admittedly among a vigorous debate, that serum 25-hydroxyvitamin D above 75 or 80 nmol/L is optimal (1)(2)(3)(4)(5)(6)(7). At these concentrations, parathyroid hormone is maximally suppressed.…”

Section: Introductionmentioning

confidence: 99%

“…*Different from June, P , 0.05 2. Data are from all 41 participants 3. BMI was determined at the February (Feb) session.…”

mentioning

confidence: 99%

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Response to Vitamin D Supplementation during Antarctic Winter Is Related to BMI, and Supplementation Can Mitigate Epstein-Barr Virus Reactivation1–3

Zwart

Mehta²,

Ploutz‐Snyder

et al. 2011

The Journal of Nutrition

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Maintaining vitamin D status without sunlight exposure is difficult without supplementation. This study was designed to better understand interrelationships between periodic vitamin D supplementation and immune function in Antarctic workers. The effect of 2 oral dosing regimens of vitamin D supplementation on vitamin D status and markers of immune function was evaluated in people in Antarctica with no UV light exposure for 6 mo. Participants were given a 2000-IU (50 μg) daily (n = 15) or 10,000-IU (250 μg) weekly (n = 14) vitamin D supplement for 6 mo during a winter in Antarctica. Biological samples were collected at baseline and at 3 and 6 mo. Vitamin D intake, markers of vitamin D and bone metabolism, and latent virus reactivation were determined. After 6 mo, the serum 25-hydroxyvitamin D concentration (mean ± SD) increased from 56 ± 17 to 79 ± 16 nmol/L and from 52 ± 10 to 69 ± 9 nmol/L in the 2000-IU/d and 10,000-IU/wk groups, respectively (main effect over time, P < 0.001). Participants with a greater BMI (participant BMI range = 19–43 g/m2) had a smaller increase in 25-hydroxyvitamin D after 6-mo supplementation (P < 0.05). Participants with high serum cortisol and higher serum 25-hydroxyvitamin D were less likely to shed Epstein-Barr virus in saliva (P < 0.05). The doses given raised vitamin D status in participants not exposed to sunlight for 6 mo, and the efficacy was influenced by baseline vitamin D status and BMI. The data also provide evidence that vitamin D, interacting with stress, can reduce risk of latent virus reactivation during the winter in Antarctica.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Response to Vitamin D Supplementation during Antarctic Winter Is Related to BMI, and Supplementation Can Mitigate Epstein-Barr Virus Reactivation1–3

Zwart

Mehta²,

Ploutz‐Snyder

et al. 2011

The Journal of Nutrition

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“…Primary hyperparathyroidism: PHPT should first be distinguished from secondary HPT, which is prevalent in patients with vitamin D deficiency [75]. The most frequent cause of PHPT is a benign single parathyroid adenoma or parathyroid gland hyperplasia.…”

Section: Other Phenotypes That Require Germline Ret Mutation Screeningmentioning

confidence: 99%

2012 European Thyroid Association Guidelines for Genetic Testing and Its Clinical Consequences in Medullary Thyroid Cancer

Elisei¹,

Alevizaki²,

Conte-Devolx³

et al. 2012

Eur Thyroid J

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Twenty-five percent of medullary thyroid cancers (MTC) are familial and inherited as an autosomal dominant trait. Three different phenotypes can be distinguished: multiple endocrine neoplasia (MEN) types 2A and 2B, in which the MTC is associated with other endocrine neoplasias, and familial MTC (FMTC), which occurs in isolation. The discovery that germline RET oncogene activating mutations are associated with 95–98% of MEN 2/FMTC syndromes and the availability of genotyping to identify mutations in affected patients and their relatives has revolutionized the diagnostic and therapeutic strategies available for the management of these patients. All patients with MTC, both those with a positive familial history and those apparently sporadic, should be submitted to RET genetic screening. Once an RET mutation has been confirmed in an index patient, first-degree relatives should be screened rapidly to identify the 50% who inherited the mutation and are therefore at risk for development of MTC. Relatives in whom no RET mutation is identified can be reassured and discharged from further follow-up, whereas RET-positive subjects (i.e. gene carriers) must be investigated and a therapeutic strategy initiated. These guideline recommendations are derived from the most recent studies identifying phenotype-genotype correlations following the discovery of causative RET gene mutations in MEN 2 eighteen years ago. Three major points will be discussed: (a) identification of patients and relatives who should have genetic screening for RET mutations, (b) management of asymptomatic gene carriers, and (c) ethics.

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“…Vitamin D has been recognised to be important not only on calcium/phosphorus metabolism, but also as an immunomodulator, playing a major role in the prevention of autoimmune diseases, cancer and also psychiatric conditions 3 5 8–11…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D and severe hypocalcaemia: the rebirth of an old disease

et al. 2013

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SUMMARYVitamin D deficiency, once thought to be eradicated, is becoming a frequent occurence in children, caused mainly by dietary insufficiency. The classical manifestation is rickets, but in infants severe hypocalcaemia may present as stridor, tetany, seizures or, rarely, heart disease. Here, we describe four infants who presented with complications of severe hypocalcaemia secondary to nutritional vitamin D deficiency. (1)

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Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction

Cited by 35 publications

References 111 publications

Response to Vitamin D Supplementation during Antarctic Winter Is Related to BMI, and Supplementation Can Mitigate Epstein-Barr Virus Reactivation1–3

Response to Vitamin D Supplementation during Antarctic Winter Is Related to BMI, and Supplementation Can Mitigate Epstein-Barr Virus Reactivation1–3

2012 European Thyroid Association Guidelines for Genetic Testing and Its Clinical Consequences in Medullary Thyroid Cancer

Hypovitaminosis D and severe hypocalcaemia: the rebirth of an old disease

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