Low Vitamin D Status in a Cancer Patient Population from Franconia, Germany

Klement, Rainer J.; Koebrunner, Petra S.; Krage, Kelley; Sweeney, Reinhart A.

doi:10.1159/000511993

Cited by 4 publications

(3 citation statements)

References 31 publications

(43 reference statements)

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“…So far, this phenomenon remains enigmatic. The observed inverse relationship between platelet count and 25(OH)D in the NAKO subcohort is consistent with the results from studies that found a higher vitamin D status associated with a lower platelet count [ 44 , 45 , 47 ]. However, antithrombotic effects of the vitamin D-vitamin D receptor axis have already been described [ 48 ] and indicate an important role of vitamin D in antithrombotic homeostasis.…”

Section: Discussionsupporting

confidence: 90%

“…Unexpectedly, individuals with better vitamin D status were more likely to have low erythrocyte count, hemoglobin, hematocrit, thrombocyte count, and leukocyte count. However, a negative association between vitamin D status and hematological parameters, including leukocyte count, was also found in other human studies [ 42 – 45 ], although other trials found no relationship [ 46 ]. So far, this phenomenon remains enigmatic.…”

Section: Discussionmentioning

confidence: 60%

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Association between vitamin D status and eryptosis–results from the German National Cohort Study

et al. 2023

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Vitamin D, besides its classical effect on mineral homeostasis and bone remodeling, can also modulate apoptosis. A special form of apoptosis termed eryptosis appears in erythrocytes. Eryptosis is characterized by cell shrinkage, membrane blebbing, and cell membrane phospholipid disorganization and associated with diseases such as sepsis, malaria or iron deficiency, and impaired microcirculation. To our knowledge, this is the first study that linked vitamin D with eryptosis in humans. This exploratory cross-sectional trial investigated the association between the vitamin D status assessed by the concentration of plasma 25-hydroxyvitamin D (25(OH)D) and eryptosis. Plasma 25(OH)D was analyzed by LC–MS/MS, and eryptosis was estimated from annexin V-FITC-binding erythrocytes by FACS analysis in 2074 blood samples from participants of the German National Cohort Study. We observed a weak but clear correlation between low vitamin D status and increased eryptosis (r = − 0.15; 95% CI [− 0.19, − 0.10]). There were no differences in plasma concentrations of 25(OH)D and eryptosis between male and female subjects. This finding raises questions of the importance of vitamin D status for eryptosis in terms of increased risk for anemia or cardiovascular events.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 60%

Association between vitamin D status and eryptosis–results from the German National Cohort Study

et al. 2023

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“…In French adults in an urban setting, lack of sunlight exposure and relatively low dietary intake of vitamin D require attention owing to the prevalence of vitamin D deficiency in that community 20 . Klement et al 21 suggested that low vitamin D in cancer patients can be enhanced with proper exposure to the sunlight and intake of supplements. They investigated the levels of calcifediol with blood counts and some anthropometric measurements.…”

Section: Discussionmentioning

confidence: 99%

Association of 25-hydroxyvitamin D with hematological profile and anthropometry in patients with glioma

Shahid

Chaudary

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Gliomas are immune system suppressive tumors, and the role of vitamin D is pivotal in the immune system. This study aimed to observe if there is any significant association between the serum levels of 25-hydroxyvitamin D with hematological indices and anthropometric measurements. METHODS: A total of 75 glioma patients were included, and the information was collected on gender, age group, area, socioeconomic status, intake of vitamin D and calcium in food and supplements, skin color, sunlight exposure, body mass index, and muscle strength. A nonparametric Kendall's tau-b correlation test was performed to find a correlation between 25-hydroxyvitamin D levels and blood counts, body mass index, and muscle strength. RESULTS: The majority of patients (72%) were having low lymphocytes followed by high granulocytes and high white blood cells. The majority were having low levels of both 25-hydroxyvitamin D (84%) and calcium (73%). Patients were mainly from urban areas, and the majority belonged to middle-class families having sedentary lifestyles. The majority of patients were not taking vitamin D supplements. An insufficient amount of sunlight exposure was found in most of them. The majority of the patients were although had normal weight but weak muscle strength (74.6%). An insignificant correlation was found between 25-hydroxyvitamin D levels with the hematological indices or anthropometric measurements in brain tumor patients. CONCLUSION: Vitamin D is a powerful immune modulator, and there is a great need for sufficient amounts of sunlight exposure and vitamin D-enriched diets to prevent cancer.

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Feasibility and metabolic effects of a 5:2 fasting intervention in women with breast cancer during radiotherapy

Klement,

Figueroa,

Weigel

et al. 2023

Holist Integ Oncol

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Purpose Obesity and insulin resistance appear to worsen prognosis of breast cancer patients. We conducted a feasibility study to test a 5:2 fasting regime in breast cancer patients undergoing radiotherapy. The intervention was rated as beneficial if it would be able to reduce fat mass while significantly improving insulin sensitivity. Methods A total of 13 non-metastatic breast cancer patients were recruited and instructed to completely abstain from food on two non-consecutive days (minimum 24 h) per week during radiotherapy. Body composition was measured weekly by bioimpedance analysis. Blood parameters were assessed before and at the end of radiotherapy. The product of triglycerides and glucose was used as a proxy for insulin sensitivity. A control group on an unspecified standard diet was assigned by propensity score matching. Results A total of twelve patients completed the study. Three patients reported side effects during fasting which were mild (grade 1). Two patients reported feeling bad while fasting, whereas five had a generally good or very good feeling. The fasting group experienced an average decrease of approximately 200 g body mass (p < 0.0001), 200 g (p = 0.002) fat mass and 100 g muscle mass (p = 0.047) per week, resulting in absolute reductions of 2.45 ± 1.19 kg body mass, 1.5 ± 1.6 kg fat mass and 0.7 ± 0.4 kg muscle mass. There was no improvement in insulin sensitivity and other markers of metabolic health except for gamma-glutamyltransferase which decreased by -7 ± 8 U/l. There was also no indication that 5:2 fasting protected against acute skin toxicity. Conclusions 5:2 fasting is safe and feasible for breast cancer patients during radiotherapy and suitable to significantly reduce fat mass, but beneficial metabolic effects could not be confirmed. To improve these results, future studies could combine 5:2 fasting with carbohydrate restriction, increased protein intake and/or exercise. Trial registration Registered on ClinicalTrials.gov under NCT05861362 on May 12, 2023 (retrospectively registered; https://clinicaltrials.gov/ct2/show/NCT05861362).

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Low Vitamin D Status in a Cancer Patient Population from Franconia, Germany

Cited by 4 publications

References 31 publications

Association between vitamin D status and eryptosis–results from the German National Cohort Study

Association between vitamin D status and eryptosis–results from the German National Cohort Study

Association of 25-hydroxyvitamin D with hematological profile and anthropometry in patients with glioma

Feasibility and metabolic effects of a 5:2 fasting intervention in women with breast cancer during radiotherapy

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