Lower Airways: Assessment and Treatment for Cough

Lai, Kefang; Zhan, Wenzhi; Zhan, Cheng

doi:10.1007/978-981-33-4029-9_5

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…Chronic P. aeruginosa colonisation is defined by isolation of the same pathogen in two or more cultures ≥3 months apart in 12 months [ 22 ]. The severity of symptoms was assessed using Medical Research Council (MRC) grade [ 23 ], cough score [ 24 ], sputum volume score [ 25 ], sputum purulence score [ 25 , 26 ] and haemoptysis score [ 27 ], and lung radiological severity was assessed using the modified Reiff score [ 28 ] ( supplementary table e1 ).…”

Section: Methodsmentioning

confidence: 99%

Total sputum nitrate/nitrite is associated with exacerbations andPseudomonas aeruginosacolonisation in bronchiectasis

Zhou,

He,

Tang

et al. 2024

ERJ Open Res

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BackgroundSputum nitrate/nitrite, which is the main component of reactive nitrogen species (RNS), is a potential biomarker of disease severity and progression in bronchiectasis. This study aimed to determine the association between nitrate/nitrite and exacerbations, airway microbiota in bronchiectasis.MethodsWe measured total nitrate/nitrite concentration in sputum samples collected from 85 patients with stable bronchiectasis, performed 16 s rRNA sequencing of sputum samples and predicted the denitrification ability of airway microbiota through PICRUSt. Relationships between sputum total nitrate/nitrite and disease severity, exacerbations and airway microbiota were examined.ResultsHigher total sputum nitrate/nitrite was associated with more severe bronchiectasis defined by E-FACED (p= 0.003) or BSI (p=0.006) and more exacerbations in prior 12 month (p=0.005). Moreover, total sputum nitrate/nitrite was also significantly higher in patients with worse cough score (p=0.03), worse sputum purulent score (p=0.01), and worse MRC score (p=0.02). In addition, the total sputum nitrate/nitrite ofP. aeruginosacolonization (PA) group was higher than that of non-P. aeruginosacolonization (NPA) group (p=0.04), meanwhile, relative abundance ofP. aeruginosawas positively correlated with the total nitrate/nitrite (r=0.337, p=0.002). Simultaneously, denitrification module (M00529) was also significantly enriched in PA group compared to NPA group through PICRUSt analyses. Using receiver-operating characteristic analysis, total nitrate/nitrite was associated with exacerbations during one year follow-up (AUC=0.741, p=0.014).ConclusionsSputum nitrate/nitrite is a biomarker of disease severity and associated withP. aeruginosacolonization in bronchiectasis.

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Section: Methodsmentioning

confidence: 99%

Total sputum nitrate/nitrite is associated with exacerbations andPseudomonas aeruginosacolonisation in bronchiectasis

Zhou,

He,

Tang

et al. 2024

ERJ Open Res

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“…Asthma sometimes manifests itself as a chronic cough called cough-variant asthma (CVA), and in several cases, it is difficult to be diagnosed. Studies show that about 25% to DOI:10.34172/ipp.2022.31351 30% of these patients experience the signs and symptoms of classic asthma over time (12,13). According to studies, CVA seems to be one of the most important causes of chronic cough worldwide.…”

Section: Key Pointmentioning

confidence: 99%

Evaluation of methacholine challenge test results in patients with chronic unexplained cough

2022

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Introduction: Asthma is one of the most common chronic diseases in adults characterized by variable airway obstruction. Asthma is diagnosed with wheezing and shortness of breath, however it sometimes manifests as a chronic cough that is difficult to diagnose and requires spirometry stimulation tests. Objectives: This study aimed to investigate the relationship between methacholine test results and respiratory symptoms in patients with chronic unexplained cough. Patients and Methods: In this cross-sectional study, 102 patients with chronic cough and normal basal spirometry were included. All patients underwent a methacholine challenge test, and their airway irritabilities were assessed. Then, the relationship between methacholine test results and clinical symptoms and also demographic characteristics were investigated. Results: Of 102 patients, 69 (67.6 %) and 33 (32.4%) were female and male, respectively. Most of patients were non-smoker (90.2%). Around 25 (24.5%) patients had a positive methacholine test. Rhinitis had a statistically significant difference between patients with positive and negative tests (positive test group: 48%, negative test group: 23.4%; P = 0.01). Postnasal discharge was reported in 60% of positive methacholine test patients, which was significant compared to the negative group (36.4%; P = 0.03). Most patients who had positive tests were housewives (76%). Logistic regression showed that female gender (OR: 7.75, 95% CI: 1.7-35.2), postnasal discharge (OR: 3.19, 95% CI: 1.25-8.2), rhinitis (OR: 3.02, 95% CI: 1.17-7.79), and allergy symptoms OR: 3.51, 95% CI: 1.35-9.18) were directly associated with a positive methacholine test. Conclusion: The presence of airway hypersensitivity, postnasal discharge, allergic rhinitis, female gender and the housewife’s job were strongly associated with a positive methacholine test.

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Lower Airways: Assessment and Treatment for Cough

Cited by 2 publications

References 56 publications

Total sputum nitrate/nitrite is associated with exacerbations andPseudomonas aeruginosacolonisation in bronchiectasis

Total sputum nitrate/nitrite is associated with exacerbations andPseudomonas aeruginosacolonisation in bronchiectasis

Evaluation of methacholine challenge test results in patients with chronic unexplained cough

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