Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru

Yamamoto, Masaaki; Adachi, Hisashi; Enomoto, Masaru; Fukami, Ako; Nakamura, Sachiko; Nohara, Yume; Sakaue, Akiko; Morikawa, Nagisa; Hamamura, Hitoshi; Toyomasu, Kohji

doi:10.1186/s12199-021-00946-0

Cited by 27 publications

(25 citation statements)

References 37 publications

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“…For uric acid and albumin biomarkers, no significant differences were found between the frail and other groups [ 78 ]. Decreased albumin values in clinical settings are associated with nutritional deterioration and inflammatory response associated with the disease, which could be the result of the aging process; however, more studies are still needed to establish this correlation with frailty [ 158 ].…”

Section: Blood Biomarkers Associated With Frailtymentioning

confidence: 99%

Frailty in Aging and the Search for the Optimal Biomarker: A Review

et al. 2022

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In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers with clinical applicability that can objectively and precisely determine the degree or risk of frailty in older people. The objective of this review was to analyze the biomarkers associated with frailty, classified according to the pathophysiological components of this syndrome (inflammation, coagulation, antioxidants, and liver function, among others). The evidence demonstrates that biomarkers associated with inflammation, oxidative stress, skeletal/cardiac muscle function, and platelet function represent the most promising markers of frailty due to their pathophysiological association with this syndrome. To a lesser extent but with the possibility of greater innovation, biomarkers associated with growth factors, vitamins, amino acids, and miRNAs represent alternatives as markers of this geriatric syndrome. Likewise, the incorporation of artificial intelligence represents an interesting approach to strengthening the diagnosis of frailty by biomarkers.

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Section: Blood Biomarkers Associated With Frailtymentioning

confidence: 99%

Frailty in Aging and the Search for the Optimal Biomarker: A Review

et al. 2022

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“…Its main function is regulating the colloidal osmotic pressure of blood. Low Alb levels, even within the normal range, are associated with weakness, trace elements, and inflammatory markers in the general population ( 43 ). Compared with Alb, prealbumin (Ttr) has a shorter half-life, faster liver synthesis rate, and predictable catabolic rate.…”

Section: Discussionmentioning

confidence: 99%

The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity

et al. 2022

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The problem of aging is mainly the increase of age-related diseases, and elderly patients have longer hospitalization and worse prognosis. Poorer nutritional status and immunosenescence may be predisposing and severe factors. The mechanism of the high incidence of diseases and poor prognosis behind aging is complex. Finding suitable aging models is of great significance to find strategies to prevent aging related events. In this study, the relationship between thyrotoxicosis and aging was investigated in mice. The results of routine blood tests and flow cytometry showed that immunosenescence occurred in thyrotoxicosis mice, which was characterized by a significant decrease in neutrophils, lymphocytes, CD4+/CD8+ and CD4+IFN-γ+ lymphocytes. Biochemical examination results showed that there were hypocholesterolemia, hypolipoproteinemia, and hyperlipidemia in thyrotoxicosis mice. Serum proteomics analysis showed that the downregulation of complement and coagulation proteins was another manifestation of declined immunity. Moreover, proteomics analysis showed that many downregulated proteins were related to homeostasis, mainly transport proteins. Their downregulation led to the disturbance of osmotic pressure, ion homeostasis, vitamin utilization, lipid transport, hyaluronic acid processing, and pH maintenance. Serum metabolomics analysis provided more detailed evidence of homeostasis disturbance, especially lipid metabolism disorder, including the downregulation of cholesterol, vitamin D, bile acids, docosanoids, and the upregulation of glucocorticoids, triglycerides, sphingolipids, and free fatty acids. The upregulated lipid metabolites were related to lipotoxicity, which might be one cause of immunosenescence and many aging related syndromes. This study provides evidence for the aging model of thyrotoxicosis mice, which can be used for exploring anti-aging drugs and strategies.

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“…49,50 An epidemiological survey found that lower albumin levels, even within the normal range, were related factors of frailty measures, trace elements, and inflammation markers in the general population. 51…”

Section: Discussionmentioning

confidence: 99%

Protein-Energy Nutritional Status of Moderately Low Protein Intake-Sago Diets Compared to Sufficiently Protein Intake-Rice Diets in Well-Nourished Lowlanders in Papua, Indonesia

et al. 2022

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Background: Protein inadequacy is prevalent in developing countries because of the high consumption of starchy staple foods. Sago, as a staple food in Papua Province, was eaten with less protein. This study aimed to analyze the nutritional status of protein-energy in well-nourished adults of the moderately low protein in-take (MLP)-sago group compared to the sufficient protein intake (SP)-rice group, in lowland Mimika, Papua. Methods: This cross-sectional-analytic study was conducted on 50 participants. Twenty-four-hour food recall, body composition, albumin, and complete blood count were used to assess the nutritional status. Results: There were no differences in the body compositions and albumin levels between the MLP-sago and SP-rice groups. Multivariate linear regression showed that the mean corpuscular volume (MCV) (β = -0.524, P = 0.007) was a predictive factor for albumin in the sago group, while in the rice group, hemoglobin (β = 0.354 P = 0.089) and white blood cell counts (β = 0.396, P = 0.059) were predictive factors. Conclusions: The MLP-sago and SP-rice groups exhibited no differences in the body and visceral protein; however different predictors of albumin were found be- tween the groups, suggesting an adaptive mechanism in the MLP-sago group to maintain normal albumin levels.

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Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru

Cited by 27 publications

References 37 publications

Frailty in Aging and the Search for the Optimal Biomarker: A Review

Frailty in Aging and the Search for the Optimal Biomarker: A Review

The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity

Protein-Energy Nutritional Status of Moderately Low Protein Intake-Sago Diets Compared to Sufficiently Protein Intake-Rice Diets in Well-Nourished Lowlanders in Papua, Indonesia

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