Lower Birth Weight and Visceral Fat Accumulation Are Related to Hyperinsulinemia and Insulin Resistance in Obese Japanese Children

Tanaka, Yukië; Kikuchi, Toru; Nagasaki, Keisuke; Hiura, Makoto; Ogawa, Yohei; Uchiyama, Makoto

doi:10.1291/hypres.28.529

Cited by 30 publications

(25 citation statements)

References 40 publications

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“…Of these parameters, WBWR showed the strongest correlation with insulin levels. We have reported previously that lower birth weight and accumulation of visceral fat are independently related to hyperinsulinemia and insulin resistance (38). These facts are consistent with the higher risk of insulin resistance found in individuals with lower birth weight and greater weight gain.…”

Section: Discussionsupporting

confidence: 87%

Lower Birth Weight Associated with Current Overweight Status Is Related with the Metabolic Syndrome in Obese Japanese Children

et al. 2007

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The purpose of this study was to clarify the relationship between lower birth weight and current overweight status and to examine the involvement of these factors in the development of the metabolic syndrome (MS) in obese Japanese children. We examined 97 obese boys (mean age 11.3 years; mean percentage overweight [POW] 52.4%) and 29 obese girls (mean age 11.1 years; mean POW 58.3%). The anthropometric measurements, blood pressure, fasting serum insulin and blood glucose, liver enzymes, lipids and lipoproteins were measured. Birth weight and gestational weeks were also recorded. The subjects were divided into either an MS group or a Non-MS group using criteria proposed for Japanese children. We compared the weight parameters (birth weight, current weight and current weight-to-birth weight ratio [WBWR]) between the two groups and analyzed the relationships between the weight parameters and metabolic derangements.There were no significant differences in age or anthropometric measurements between the two groups.However, birth weight in the MS group was lower than that in the Non-MS group, while WBWR of the MS group was higher than that in the Non-MS group. Blood pressure and serum insulin correlated positively with WBWR. These findings suggested that lower birth weight with current overweight status was associated with the MS in obese Japanese children. We were unable to clarify whether subjects with lower birth weight who achieved proper weight gains had the same risk as subjects with appropriate birth weight. However, they should be assisted to grow adequately to prevent future metabolic derangements. (Hypertens Res 2007; 30: 627-634)

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Section: Discussionsupporting

confidence: 87%

Lower Birth Weight Associated with Current Overweight Status Is Related with the Metabolic Syndrome in Obese Japanese Children

et al. 2007

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“…In our previous study, birth weight showed an inverse relation with serum total cholesterol and triglyceride levels in 207 male medical students (25). Tanaka et al reported that both lower birth weight and visceral fat accumulation were independently related to hyperinsulinemia and insulin resistance in obese Japanese children (26). More recently, Ramadhani et al (27) also reported that lower birth weight predicted the metabolic syndrome in 749 young adults aged 26-31 years who participated in the Atherosclerosis Risk in Young Adults (ARYA)-study, particularly through higher serum triglycerides and higher SBP.…”

Section: Discussionmentioning

confidence: 83%

Lower Birth Weight Is Associated with Higher Resting Heart Rate during Boyhood

et al. 2007

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There is substantial evidence that low birth weight is associated with the development of cardiovascular disease in adult life. Moreover, resting heart rate is a prognostic factor of cardiovascular morbidity and mortality. However, there are scarce data regarding the association between birth weight and resting heart rate in later life. Therefore, we investigated the association of anthropometric data at birth and hemodynamic indices including resting heart rate in Japanese boys. The data of 1,107 male students of a junior high school in Tokyo, Japan, who underwent a medical check-up in the year of admission to the school (12 or 13 years old) were used. Information on anthropometric data at birth based on "The Maternal and Child Health Handbook" was obtained from 573 students. From a standard 12-channel resting electrocardiogram, 8 cardiac cycles were used to estimate heart rate. Resting heart rate correlated positively with body mass index at the same age (r =0.100, p =0.017) and correlated negatively with birth weight (r =-0.102, p =0.015), height at birth (r =-0.125, p =0.003), and head circumference at birth (r =-0.095, p =0.025). The negative correlation of anthropometric data at birth with heart rate at the age of 12 or 13 was independent of body mass index at the same age. The mean value of resting heart rate at the age of 12 or 13 adjusted for body mass index at the same age was significantly higher in the lower tertile of birth weight than in the higher tertile of birth weight (81.7 vs. 78.5 beats/min, p =0.028). In conclusion, lower birth weight is associated with higher resting heart rate during boyhood, suggesting that elevated heart rate may be one mechanism linking small

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“…Because of these limitations, alternative, simple, noninvasive methods of assessing regional adiposity are needed. The use of waist circumference 16) and visceral fat thickness by ultrasonography 15,[18][19][20][21] as predictors of cardiovascular risk factors has been reported. In this study, we used Pmax measured by ultrasonography as the cutoff point of visceral obesity because some studies have reported that Pmax had a close relationship to visceral fat accumulation evaluated by CT scanning 15,18) and serum insulin level 20,21) .…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome, Diabetes and Subclinical Atherosclerosis as Assessed by Carotid Intima-Media Thickness

Kawamoto

Tomita

Ohtsuka

et al. 2007

JAT

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Lower Birth Weight and Visceral Fat Accumulation Are Related to Hyperinsulinemia and Insulin Resistance in Obese Japanese Children

Cited by 30 publications

References 40 publications

Lower Birth Weight Associated with Current Overweight Status Is Related with the Metabolic Syndrome in Obese Japanese Children

Lower Birth Weight Associated with Current Overweight Status Is Related with the Metabolic Syndrome in Obese Japanese Children

Lower Birth Weight Is Associated with Higher Resting Heart Rate during Boyhood

Metabolic Syndrome, Diabetes and Subclinical Atherosclerosis as Assessed by Carotid Intima-Media Thickness

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