We study the problem of counting real simple rational functions ϕ with prescribed ramification data (i.e. a particular class of oriented real Hurwitz numbers of genus 0). We introduce a signed count of such functions which is independent of the position of the branch points, thus providing a lower bound for the actual count (which does depend on the position). We prove (non-)vanishing theorems for these signed counts and study their asymptotic growth when adding further simple branch points. The approach is based on Itenberg and Zvonkine (Comment Math Helv 93(2), 441-474, 2018) which treats the polynomial case.