Lower cerebello-cortical functional connectivity in veterans with reactive aggression symptoms: A pilot study

Wolfs, Elze M L; Lutterveld, Remko van; Varkevisser, Tim; Klaus, Jana; Geuze, Elbert; Schutter, Dennis J.L.G.

doi:10.1016/j.jpsychires.2023.01.023

Journal of Psychiatric Research

2023

DOI: 10.1016/j.jpsychires.2023.01.023

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Lower cerebello-cortical functional connectivity in veterans with reactive aggression symptoms: A pilot study

Elze M L Wolfs

Remko van Lutterveld

Tim Varkevisser

et al.

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2023

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Cited by 2 publications

References 78 publications

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The cerebellum during provocation and aggressive behaviour: A 7 T fMRI study

Wolfs,

Van der Zwaag,

Priovoulos

et al. 2023

Imaging Neuroscience

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Increasing empirical evidence points towards the involvement of the cerebellum in anger and aggressive behaviour. However, human functional neuroimaging studies so far have emphasised the involvement of subcortical and cortical regions, rather than examining the contributions of the cerebellum. In the present study, 7 T functional magnetic resonance imaging (fMRI) was used to assess cerebellar activation during provocation and aggressive behaviour elicited by the Point Subtraction Aggression Paradigm in 29 healthy adult volunteers. Provocations resulted in left posterior cerebellar activation, while right posterior cerebellar activation was associated with aggressive behaviour. Our findings confirm the involvement of distinct and lateralised non-motor related cerebellar areas during provocation and aggressive behaviour. This study adds to the growing recognition of the posterior cerebellar regions in emotion- and cognition-dedicated processes and to the role of the little brain in human aggression.

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The cerebellum during provocation and aggressive behaviour: A 7 T fMRI study

Wolfs,

Van der Zwaag,

Priovoulos

et al. 2023

Imaging Neuroscience

View full text Add to dashboard Cite

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Effects of Chemical Warfare Throughout Time on Mental Disorder Symptoms and Brain Executive Functions of Veterans Exposed to Chemical Weapons

Karimi,

Avakh,

Abdollahi

et al. 2023

Ann Mil Health Sci Res

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Background: During the Iran-Iraq war (1980 - 1988), Iran was subjected to chemical attacks for over five years. These attacks left many mental injuries, especially for the veterans exposed to chemical weapons. Objectives: This case-control study compared mental disorder symptoms and brain executive functions of veterans exposed to chemical weapons with healthy individuals. Methods: The present study was conducted on veterans exposed to chemical weapons during the war. The control group comprised healthy individuals matched to the cases based on age, gender, occupation, level of education, and place of residence. One hundred seventy participants were included in the study, with 85 individuals in each group. The Symptom Checklist-90-Revised (SCL-90-R) and Nejati questionnaire were used to collect data on the symptoms of mental disorders and brain executive functions. Multivariate analysis of variance was used for data analysis. Results: The findings revealed that the total effect of the subscales of mental disorders in all nine domains was significantly higher in veterans exposed to chemical weapons than in healthy individuals (P < 0.05). In addition, the actual impact of the subscales of the executive brain functions of veterans exposed to chemical weapons was significantly lower compared to healthy individuals (P < 0.05). Conclusions: Our findings showed that veterans exposed to chemical weapons exhibited higher mental disorder symptoms across all domains than the control group. Moreover, veterans demonstrated weaker cognitive functions in terms of executive brain functions compared to healthy individuals. The implications of these findings are significant for mental health specialists working with veterans exposed to chemical weapons.

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Lower cerebello-cortical functional connectivity in veterans with reactive aggression symptoms: A pilot study

Cited by 2 publications

References 78 publications

The cerebellum during provocation and aggressive behaviour: A 7 T fMRI study

The cerebellum during provocation and aggressive behaviour: A 7 T fMRI study

Effects of Chemical Warfare Throughout Time on Mental Disorder Symptoms and Brain Executive Functions of Veterans Exposed to Chemical Weapons

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