Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

Dinther, Maud van; Hooghiemstra, Astrid M.; Bron, Esther E.; Versteeg, Adriaan; Leeuwis, Anna E.; Kalay, Tugba; Moonen, Justine E F; Kuipers, Sanne; Backes, Walter H.; Jansen, Jacobus F.A.; Osch, M.J.P. van; Biessels, Geert-Jan; Staals, Julie; Oostenbrugge, Robert J. van

doi:10.1002/alz.13408

Cited by 10 publications

(9 citation statements)

References 56 publications

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“…It appears that global or regional CBF or ATT are not associated with contemporaneous cognitive function in healthy older adults, but they may still help explain or predict changes in cognitive function over time. The predictive capacity of CBF has been shown previously, 14 although understanding of which regions and cognitive domains are most affected by could be improved. Given that the present data indicates that ATT may be more sensitive to age-related decline than CBF, the predictive capacity of ATT should be investigated as it could be an early biomarker of cerebrovascular-related cognitive decline in healthy populations.…”

Section: Discussionmentioning

confidence: 86%

“…16 Interestingly, however, a follow-on study to this aforementioned study did find longitudinal associations between CBF and cognitive function in a subset of these participants (n=89) (2 yr follow-up). 14 Specifically, a lower baseline CBF (global, frontal, parietal, temporal, and occipital regions) predicted a greater decline in global cognition and attention/psychomotor speed whereas only frontal and temporal baseline CBF predicted decline in memory, and that baseline global or regional CBF were not predictive of executive or language functions. Collectively, these data do suggest an importance of CBF for cognitive function, but this is both domain- and region- specific, and only apparent when analysed over time.…”

Section: Discussionmentioning

confidence: 88%

“…3 It appears that global or regional CBF or ATT are not associated with contemporaneous cognitive function in healthy older adults, but they may still help explain or predict changes in cognitive function over time. The predictive capacity of CBF has been shown previously, 14 although understanding of which regions and cognitive domains are most affected by could be improved.…”

Section: No Association Between Cbf or Att And Cognitive Functionmentioning

confidence: 86%

“…7 Blood flow to and within the brain is important for brain health since the brain has a high relative energy consumption but lacks intracellular energy stores, meaning hypoperfusion can result in cell death and neuronal dysfunction. 8,9 Higher CBF has been linked with superior cognitive function in healthy older adults, [10][11][12][13][14] although not all studies converge. 12,[15][16][17] It is well established that CBF declines with age 4,18,19 and previous research in older adults has already identified some modifiable determinants of CBF.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of cerebral blood flow and arterial transit time in healthy older adults

Feron,

Segaert,

Rahman

et al. 2023

Preprint

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Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (n=78, aged 60–81 yrs). Associations between cardiorespiratory fitness and CBF or ATT were of particular interest as the impact of cardiorespiratory fitness is not clear in existing literature. Secondly, this study assessed whether CBF or ATT relate to cognitive function in older adults. Results from multiple linear regressions found higher BMI was associated with lower global CBF (β=-0.35,P=0.008) and a longer global ATT (β=0.30, P=0.017), global ATT lengthened with increasing age (β=0.43,P=0.004), and higher cardiorespiratory fitness was associated with longer ATT in parietal (β=0.44,P=0.004) and occipital (β=0.45,P=0.003) regions. Global or regional CBF or ATT were not associated with processing speed, working memory, or attention. In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health. ATT may be more sensitive to age-related decline than CBF, and therefore useful for early detection and management of cerebrovascular impairment. Finally, cardiorespiratory fitness appears to have little effect on CBF but may induce longer ATT in specific regions.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 88%

Section: No Association Between Cbf or Att And Cognitive Functionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Determinants of cerebral blood flow and arterial transit time in healthy older adults

Feron,

Segaert,

Rahman

et al. 2023

Preprint

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“…VCI is a type of cognitive decline caused by blood vessel dysfunction in the brain. Its pathophysiological mechanism is complex and involves multiple factors and processes, including vascular lesions [ 26 ], changes in cerebral blood flow [ 27 ], nerve damage, and metabolic disorders. The dysregulation of cerebral perfusion is a prevalent cause underlying VCI.…”

Section: Pathophysiological Mechanisms Of Vcimentioning

confidence: 99%

Potential Intersections between lncRNA, Vascular Cognitive Impairment, and Immunization Strategies: Insights and Future Directions

Fan,

Xiao,

Zhang

2024

Vaccines

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Vascular cognitive impairment (VCI) encompasses a wide range of cognitive disorders stemming from cerebrovascular issues, such as strokes or small vessel disease. These conditions often pose challenges to traditional diagnostic approaches due to their multifactorial nature and varied clinical presentations. Recently, next-generation sequencing (NGS) technologies have provided detailed analyses of long non-coding RNAs (lncRNAs) in the molecular pathobiology of VCI. These new findings help with molecular-based diagnostics and treatments of VCI. Within this realm, the concept of immune modulation, especially through specific vaccinations, emerges as a promising therapeutic strategy in VCI mitigation. In this review, we comprehensively elucidate the function of lncRNAs in VCI, emphasizing the advanced understanding of VCI’s molecular underpinnings made possible through NGS technologies. Significant focus is placed on the immune system’s role in VCI, particularly the neuroinflammatory processes which are consequential to cerebrovascular abnormalities. We believe that lncRNAs participate in regulating these immunological pathways, potentially guiding the development of vaccines targeting VCI. In this context, we propose a novel perspective: using knowledge about lncRNA profiles and functions to guide vaccine development, we can potentially exploit the body’s immune response to mitigate or prevent VCI. This approach has the potential to revolutionize VCI management by introducing targeted immunization strategies informed by molecular signatures, a concept that remains largely unexplored in current research endeavors. In addition, we summarize current progress and propose future directions, advocating for robust, interdisciplinary studies to validate the potential intersections between lncRNA landscapes, VCI pathology, and immunology. This review aims to spur innovative research and promote the development of lncRNA-informed vaccine strategies as proactive interventions against the cognitive consequences of VCI.

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Cerebral blood flow and arterial transit time responses to exercise training in older adults

Feron,

Rahman,

Fosstveit

et al. 2024

NeuroImage

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Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

Cited by 10 publications

References 56 publications

Determinants of cerebral blood flow and arterial transit time in healthy older adults

Determinants of cerebral blood flow and arterial transit time in healthy older adults

Potential Intersections between lncRNA, Vascular Cognitive Impairment, and Immunization Strategies: Insights and Future Directions

Cerebral blood flow and arterial transit time responses to exercise training in older adults

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