Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community

Abstract

BackgroundEvidence regarding the association of lower extremity peripheral arterial disease with quality of life (QOL) is mainly from selected clinical populations or relatively small clinical cohorts. Thus, we investigated this association in community‐derived populations.Methods and ResultsUsing data of 5115 participants aged 66 to 90 years from visit 5 (2011‐2013) of the Atherosclerosis Risk in Communities Study, we quantified the associations of ankle‐brachial index (ABI) with several QOL parameters, including 12‐item Short‐Form Health Survey (SF‐12), after accounting for potential confounders using linear and logistic regression models. Peripheral arterial disease defined by an ABI <0.90 (n=402), was independently associated with a low SF‐12 Physical Component Summary score (−3.26 [95% CI −5.60 to −0.92]), compared to the ABI reference 1.10 to 1.19 (n=1900) but not with the Mental Component Summary score (−0.07 [−2.21 to 2.06]). A low ABI was significantly associated with poorer status of all SF‐12 physical domains (physical functioning, role‐physical, bodily pain, and general health) but only vitality out of 4 mental domains. Similarly, low ABI values were more consistently associated with other physically related QOL parameters (leisure‐time exercise/activity/walking) than mentally related parameters (significant depressive symptoms and hopeless feeling). Lower physical QOL was observed even in individuals with borderline low ABI (0.90 to 0.99; n=426).ConclusionsLow ABI (even borderline) was independently associated with poor QOL, especially for physical components, in community‐dwelling older adults. QOL is a critical element for older adults, and thus, further studies are warranted to assess whether peripheral arterial disease‐specific management can improve QOL in older populations.

Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry

“…Younger age, female sex, not being married, greater economic burden, more difficulty getting care, chronic lung disease, back pain, bilateral (vs unilateral) PAD, more severe intermittent claudication and lack of prior participation in an exercise program were associated with poorer health status. These findings extend the work of others 13 and provide new insights into the profiles of patients presenting with worse health status at the time of an initial visit with a 14,15 or through disease-specific QoL questionnaires 13,16,17 designed to explore a particular range of problems and experiences confronting patients with PAD, 18 have found that sex, 13 age, 19 worsening ABI 20 and treatment predict QoL. We also observed that unmarried patients and those with back pain have significantly poorer disease-specific health status, relationships that have not been described to date.…”

Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient‐level pooled data analysis

“…Patients with symptomatic PAD are known to be at‐risk for poor quality of life and functional status. Prior reports have demonstrated that ABI is associated with poor quality of life scores, especially physical functioning metrics . In the current analysis, we demonstrate that ABI and Rutherford category significantly improved on discharge after IVL therapy compared with baseline values in patients with these data collected.…”

Factors Influencing on the Mortality in Patients With Obliterating Diseases of Lower Limb Arteries

“…В развитых странах в связи с постарением населения следует ожидать уве-личения распространенности облитерирующих забо-леваний артерий нижних конечностей (ОЗАНК). По сравнению с другими сердечно-сосудистыми заболе-ваниями ОЗАНК ассоциированы с наибольшим сни-жением качества жизни [2] и наибольшими затратами на лечение [3,4]. При атеросклерозе с манифестацией в любом сосудистом отделе выявляются поражения и в других сосудистых бассейнах вследствие системного характера процесса [5,6], так, с возрастом чаще вы-являются и бессимптомные изменения ЭКГ [7].…”