Lower frequency of antibodies to MOG in Brazilian patients with demyelinating diseases: An ethnicity influence?

Papais-Alvarenga, Regina María; Neri, Vanderson Carvalho; Araújo, Ana Carolina Ribeiro de Araújo e; Silva, Elizabeth Batista da; Alvarenga, Marcos Papais; Pereira, Ana Beatriz Calmon Nogueira da Gama; Brandão, Anna Christiany; Alvarenga-Filho, Hélcio; Guimarães, Marcell Pourbaix Morisson; Marignier, Romain; Barros, Priscila O.; Bento, Cleonice Melo; Vasconcelos, Cláudia Cristina Ferreira

doi:10.1016/j.msard.2018.07.026

Cited by 20 publications

(19 citation statements)

References 36 publications

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“…Interestingly the German, UK and the Korean studies reported the same, with female to male ratios of 2.8, 2.3 and 1.4:1, respectively. (8,11) Similar to previous observations, (10,26,27) MOG antibody positive patients are more likely to be Caucasians (56% of our cohort).…”

Section: Discussionsupporting

confidence: 91%

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder

Salama

Pardo

Lévy

2019

Multiple Sclerosis and Related Disorders

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Background.-Serological antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with a relapsing autoimmune demyelinating disease of the central nervous system. Initially identified in the context of acute disseminated encephalomyelitis, persistent seropositivity of MOG antibodies is now recognized as a variant of neuromyelitis optica spectrum disorder (NMOSD). Objectives:The aim of the study is to describe the epidemiological and clinical features of MOG antibody positive cases and compare our findings with those previously published.Methods.-This is a retrospective descriptive study of 23 patients with MOG antibody disease who were cared for at Johns Hopkins Hospital over the period from 2015 to 2018. MOG testing was done at Johns Hopkins using the cell based assay (CBA). We describe their epidemiological and clinical features.Results.-Twenty-three patients were included in the study with a female to male ratio of 2.3:1. The mean age of the cohort was 42.6 years, while the mean age at onset was 37 years. The most frequent initial presentation was optic neuritis, followed by ADEM-like encephalopathic clinical picture and transverse myelitis. Five patients showed a monophasic disease course while the rest experienced a relapsing phenotype. Nine patients (39%) experienced immediate relapses on withdrawal of steroids.conclusions.-Our cohort showed clinical characteristics comparable with previously published reports of MOG antibody disease worldwide. Unique features of MOG antibody disease are: high frequency of optic neuritis attacks, good long term neurological recovery and sensitivity to steroid use and withdrawal.

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Section: Discussionsupporting

confidence: 91%

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder

Salama

Pardo

Lévy

2019

Multiple Sclerosis and Related Disorders

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“…The frequency of autoantibodies in ADS has been proposed to be affected by ethnicity and race. 21 Hence, such seroprevalence studies are the need of the hour in populations of different…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of MOG and AQP4 Antibodies and Outcomes in an Indian Cohort of Pediatric Acquired Demyelinating Syndromes

et al. 2022

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This study aimed to determine the seropositivity of myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) and aquaporin-4 antibodies (AQP4-Ab) and outcomes in children with acquired demyelinating syndromes (ADS). Children (6months-15years) with suspected ADS were enrolled and tested for MOG-Ab and AQP4-Ab prospectively over 18 months at a tertiary-care hospital in North India. Children with proven non-immune mediated neurological disorders were enrolled as controls. Of 79 children with suspected ADS, 66 were enrolled. Among the enrolled children with ADS, ADEM (25) was the commonest first clinical event followed by ON (20) and TM [19; one child had ON and TM simultaneously (NMOSD)], while two children had CIS apart from ON and TM. Fourteen (21.2%, CI 11.3-31.1) tested positive for one antibody [12 (18.1%; 95% CI 10.5-25.5%) for MOG-Ab and two (3%; 95% CI 0-7.2%) for AQP4-Ab]. None of the 62 controls tested positive for any antibody. The final diagnosis in those with the monophasic ADS was ADEM (21), ON (13), TM (16), and other CIS (1) while that in children with recurrent events was MDEM (2), NMOSD (3), ADEM-ON (4), recurrent ON (4), and MS (2). Among those with the first event, 4/51 (7.8%; 95%CI 0.5-15.2%) were MOG-Ab positive and two AQP4-Ab positive, whereas, 8/15 [53.3%, (95%CI: 28.1-78.6%)] with recurrent events [MDEM (2), ADEM-ON (4), recurrent ON (1), and recurrent TM (1)] were MOG-Ab positive. Hence, MOG-Ab are the most common antibodies detected in one in five children with pediatric ADS, especially in relapsing disease. AQP4-Ab are rare in children with ADS.

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“…No MOG-Ab(+) (myelin oligodendrocyte glycoprotein antibodies) patient was included but we did not obtain MOG-Ab status in some of our AQP4-Ab(–) patients since the test became available only recently. However, MOG-Ab prevalence is lower than 10% in NMOSD patients from African ancestry, 18 which strongly minimizes any possible bias. Although our study includes the largest cohort of first SC attacks, we could not analyze differences in sub-groups according to AQP4 status, so future studies should be extended to MOG-Ab(+) patients.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder

Bonnan

Debeugny

Mejdoubi³

et al. 2019

Mult Scler

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Background: While spinal cord (SC) attacks of neuromyelitis optica spectrum disorder (NMOSD) are often devastating, signs predictive of their poor clinical outcome have been elusive until now, except for the delay in initiating plasma exchange (PE). Objective: We studied the correlation between conventional non-standardized magnetic resonance imaging (MRI) parameters, PE treatment, and clinical data obtained at nadir and recovery. Methods: Retrospective study of first SC attacks of NMOSD. Results: Sixty-nine Afro-Caribbean NMOSD patients were included (aquaporin-4 (AQP4) antibodies positive in 65%). Median nadir and residual expanded disability status score (EDSS) were, respectively, 7.5 and 4.0. In bivariate analysis, all conventional MRI parameters were correlated with nadir and residual EDSS. In multivariate analysis, nadir EDSS correlated with lesion length ( p = 0.022) and edema ( p = 0.019), whereas residual EDSS correlated with T1w (T1-weighted) hypointense signal ( p = 0.003). Gadolinium enhancement was not associated with outcome. Conclusion: A specific pattern of lesions in conventional MRI data is differentially associated with nadir and residual EDSS. Lesions associated with poor prognosis should prompt highly efficient treatment.

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Lower frequency of antibodies to MOG in Brazilian patients with demyelinating diseases: An ethnicity influence?

Cited by 20 publications

References 36 publications

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder

Seroprevalence of MOG and AQP4 Antibodies and Outcomes in an Indian Cohort of Pediatric Acquired Demyelinating Syndromes

Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder

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