Lower levels of cerebrospinal fluid amyloid ß (Aß) in non-demented Indian controls

Subramanian, S.; Sandhyarani, Boya; Shree, A.N. Divya; Murthy, K. Krishna; Kalyani, K.; Kumar, Sunil; Pradeep, .; Noone, Mohin Jeslie; Taly, Arun B.

doi:10.1016/j.neulet.2006.08.018

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Curcuminoids are the main polyphenol constituents of turmeric (Curcuma longa) and have 3 chemical components, including curcumin (75-80%), demethoxycurcumin (15-20%), and bisdemethoxycurcumin (3-5%). Epidemiologic data suggest that dietary curcumin intake is positively related to cognitive function in healthy elderly individuals (47), with evidence that concentrations of Ab and tau are lower in populations that consume large amounts of curcumin (48,49). To our knowledge, there are 7 clinical investigations of the safety, tolerance, pharmacokinetics, and treatment effects of curcumin in AD (NIH registry) (Table 1), although observations from 4 of these are still pending.…”

Section: Polyphenol Compoundsmentioning

confidence: 99%

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

Bigford

Rossi

2014

Advances in Nutrition

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Neurodegenerative disorders and diseases (NDDs) that are either chronically acquired or triggered by a singular detrimental event are a rapidly growing cause of disability and/or death. In recent times, there have been major advancements in our understanding of various neurodegenerative disease states that have revealed common pathologic features or mechanisms. The many mechanistic parallels discovered between various neurodegenerative diseases suggest that a single therapeutic approach may be used to treat multiple disease conditions. Of late, natural compounds and supplemental substances have become an increasingly attractive option to treat NDDs because there is growing evidence that these nutritional constituents have potential adjunctive therapeutic effects (be it protective or restorative) on various neurodegenerative diseases. Here we review relevant experimental and clinical data on supplemental substances (i.e., curcuminoids, rosmarinic acid, resveratrol, acetyl-L-carnitine, and ω-3 (n-3) polyunsaturated fatty acids) that have demonstrated encouraging therapeutic effects on chronic diseases, such as Alzheimer's disease and neurodegeneration resulting from acute adverse events, such as traumatic brain injury.

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Section: Polyphenol Compoundsmentioning

confidence: 99%

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

Bigford

Rossi

2014

Advances in Nutrition

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“…In spite of the genetic differences, there is also a difference in the pathology of AD in India, with a decrease in β-amyloid 1–42 in both normal controls and those patients who do develop AD, as well as a decrease in hyperphosphorylated tau. 82 , 83 It has been postulated that the reduced incidence or severity of AD in India might, beyond genetics, reflect differences in diet or environment. 74 Indeed, people in India consume large amounts of curcumin, about 80–200 mg/day, 84 which has long been known to have anti-inflammatory and antioxidant effects.…”

Section: Current Treatmentsmentioning

confidence: 99%

Curcumin: a natural substance with potential efficacy in Alzheimer’s disease

Potter¹

2013

JEP

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Curcumin is a component of turmeric, a spice used in many types of cooking. Epidemiological evidence suggesting that populations that eat food with a substantial amount of curcumin were at lower risk of Alzheimer’s disease (AD) led to the idea that this compound might have a neuroprotective effect. Curcumin has substantial antioxidant and anti-inflammatory effects, and is being used as a potential preventative agent or treatment for many types of cancer. There is evidence to suggest that the addition of curcumin to cultured neuronal cells decreases brain inflammation and protects against β-amyloid-induced neurotoxicity. Curcumin also protects against toxicity when β-amyloid is administered to produce animal models of AD. Curcumin decreases β-amyloid formation from amyloid precursor protein, and also inhibits aggregation of β-amyloid into pleated sheets. Studies in transgenic mice with overproduction of β-amyloid demonstrate a neuroprotective effect of curcumin as well. Cognitive function was also improved in these animal models. Clinical trials of curcumin in AD have not been very promising. It is possible that this is due to poor oral bioavailability of curcumin in humans, and thus several approaches are being developed to improve delivery systems or to create analogs that will mimic the neuroprotective effects and easily reach the brain. The lack of efficacy of curcumin in humans with AD may also result from treating for too short a time or starting treatment too late in the course of the disease, where substantial neuronal death has already occurred and cannot be reversed. Curcumin may be beneficial in protecting against development or progression of AD if taken over the long term and started before symptoms of AD become apparent.

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“…In order to establish the reference range in our laboratory set up, we have earlier analyzed CSF samples collected from non-demented individuals between 20 and 65 years of age. Measurement of Aß42 levels from these controls displayed a wide distribution ranging from 150 pg/ml to 850 pg/ml with an average Aß42 level of 493 AE 27.1 pg/ml (Subramanian et al, 2006) which has been used as the normative data for the present study.…”

Section: Discussionmentioning

confidence: 99%

Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia – A study from Southern India

Huded

Bharath

Chandra

et al. 2015

Asian Journal of Psychiatry

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Lower levels of cerebrospinal fluid amyloid ß (Aß) in non-demented Indian controls

Cited by 6 publications

References 26 publications

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

Curcumin: a natural substance with potential efficacy in Alzheimer’s disease

Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia – A study from Southern India

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Lower levels of cerebrospinal fluid amyloid ß (Aß) in non-demented Indian controls

Cited by 6 publications

References 26 publications

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

Curcumin: a natural substance with potential efficacy in Alzheimer&rsquo;s disease

Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia – A study from Southern India

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Product

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Curcumin: a natural substance with potential efficacy in Alzheimer’s disease