1998
DOI: 10.1212/wnl.51.4.1225
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Lower limb tremor in Machado-Joseph disease

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Cited by 10 publications
(7 citation statements)
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“…We also observed a slight improvement of the tremors, which is in agreement with our previous result using LiCl alone in these mice (Duarte-Silva et al, 2014), suggesting that this improvement might be due to that component of the treatment regimen. The presence of tremors in human patients is a rare event and can be treated with levodopa (Coutinho and Sequeiros, 1981;Ishida et al, 1998;Nandagopal and Moorthy, 2004;Bettencourt et al, 2011), so this improvement may not be very relevant in the disease context.…”
Section: Discussionmentioning
confidence: 99%
“…We also observed a slight improvement of the tremors, which is in agreement with our previous result using LiCl alone in these mice (Duarte-Silva et al, 2014), suggesting that this improvement might be due to that component of the treatment regimen. The presence of tremors in human patients is a rare event and can be treated with levodopa (Coutinho and Sequeiros, 1981;Ishida et al, 1998;Nandagopal and Moorthy, 2004;Bettencourt et al, 2011), so this improvement may not be very relevant in the disease context.…”
Section: Discussionmentioning
confidence: 99%
“…Among hereditary ataxic disorders, patients with SCA10 7,8 or fragile X-associated tremor/ataxia syndrome 9 have prominent postural tremor as the disease hallmark. Postural tremor has been reported to be present in other forms of SCA patients in several case reports, [10][11][12][13][14][15][16][17][18][19] and can also be a prominent feature in CAG-repeat SCAs, 20-23 especially in SCA2. 23 However, the sample size in these studies is moderate (n 5 22-85), and there is no systemic comparison between SCA patients with and without postural tremor in terms of genetics and rate of clinical progression.…”
Section: Introductionmentioning
confidence: 99%
“…SCA3 patients presenting initially with ET have yet to be reported. Interestingly our literature review found a report of a Japanese SCA3 patient who presented with prominent posture‐related lower limb tremor, together with ataxia 11. Unlike SCA2, reports of prominent postural tremor associated with ataxia is lacking in SCA3.…”
Section: Discussionmentioning
confidence: 94%