Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management

Hwang, Jacqueline R; Khachemoune, Amor

doi:10.1007/s00403-022-02345-z

Cited by 4 publications

(4 citation statements)

References 51 publications

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“…We believe this change in the epidemiological profile of lip BCC is due to the extension of the skin tumor to the lower lip, causing a greater prevalence in this anatomic site. As it is known, UVB is the main BCC predisposing factor, and it increases its development risk by 1.5-fold ( 17 , 18 ). In this way, this finding is explained by the anatomical lip position, which allows a higher incidence of UV radiation in this anatomic site, causing the initiation and promotion of lip carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma and basal cell carcinoma of the lips: 25 years of experience in a northeast Brazilian population

Silva,

Bortoli,

Leite

et al. 2024

Med Oral

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Background The lips are the transition zone between the facial skin and the oral mucosa and are the site of alterations related to a broad spectrum of etiologies. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the most prevalent neoplasms affecting lips. This study evaluated the demographic and clinicopathological features of the SCC and BCC in the lip. Material and Methods A retrospective cross-sectional descriptive study (1994-2019) was carried out. Demographic and clinicopathologic data were collected from a hospital’s dermatological service and an oncologic hospital. The data were submitted to descriptive analysis and Pearson's chi-square and Fisher's exact tests ( p ≤ 0.05). Results 417 medical records were analyzed, of which 323 corresponded to SCC (77.5%) and 94 to BCC (22.5%). SCC showed more frequency in males (58.8%) and BCC in females (54.3%). The lower lip was significantly affected in male patients ( p < 0.0001) and by both neoplasms (70.6% and 56.4%, respectively; p = 0.014). SCC and BCC were mainly treated with surgery (88.3% and 93.2%, respectively). Surgical margin was frequently negative in SCC and BCC (87%; 72.3%, respectively), and no recurrence was observed in 79.9% of SCC and 69.1% of BCC cases. Conclusions SCC was more frequent in male patients, while BCC showed more frequency in female patients. Both neoplasms mainly affect the lower lip. Understanding the epidemiological profile of these lesions in the lip, as well as their etiology and clinical features, is fundamental for appropriate clinical conduct and the creation and/or amplification of preventive measures. Key words: Epidemiology, oral pathology, oral mucosal lesions.

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma and basal cell carcinoma of the lips: 25 years of experience in a northeast Brazilian population

Silva,

Bortoli,

Leite

et al. 2024

Med Oral

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“…A 47-year-old male, an agronomist engineer and tobacco user, who spends a significant part of his day under unprotected sun exposure to the head and lips, where harmful rays directly affect his skin, was a determining factor for the appearance of neoplastic tissue on his lower lip [1,3,6,10]. Upon noticing the neoplastic tissue, he immediately sought medical help.…”

Section: Patient Information Clinical Findings Timeline Diagnostic As...mentioning

confidence: 99%

“…Labial squamous cell carcinoma (LSCC) is a form of skin cancer that affects the lips, primarily the lower lip [1][2][3]. It develops from squamous cells, which compose the outermost layer of the skin.…”

Section: Introductionmentioning

confidence: 99%

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Squamous cell carcinoma, are healthcare professionals prepared to identify it? A case report

Arroyo,

Maranini,

Kassis

et al. 2024

MedNEXT

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Squamous cell carcinoma (SCC), also known as squamous cell carcinoma, is a type of cancer that originates in the squamous cells of the skin and has different stages according to the involved cellular layer. In the early stage, the process begins with chronic sun exposure, leading to DNA damage in the squamous cells of the epidermis. Initiating in pre-cancerous lesions such as actinic keratosis, occurring in the outermost layers of the epidermis. In the intermediate stage, squamous cells undergo additional mutations, becoming cancerous but still restricted to the epithelial layer without invading deeper structures. While it is only in the epidermis, it is considered carcinoma in situ, as it is confined to this cellular layer and has not invaded the basement membrane. In the advanced stage, cancer cells invade the deeper layers of the epidermis, crossing the basement membrane, becoming basal cell cancer, and can reach the dermis. After reaching the dermis, cancer cells have the potential to spread to distant areas from the primary site, where the metastasis process begins and occurs, potentially affecting regional lymph nodes and other organs. In addition to the layers of the skin, cancer cells can spread to other tissues and organs, forming metastases that are cellular copies of their site of origin. At all stages, it is crucial to emphasize that the progression of squamous cell carcinoma involves progressive genetic mutations that confer malignant characteristics to the cells. Early diagnosis and treatment are essential to improve recovery prospects. Furthermore, prevention by avoiding alcohol, tobacco, and adequate sun protection plays a crucial role in reducing the risk of developing this type of cancer. Therefore, the present study aims to present a clinical case report on Labial Squamous Cell Carcinoma and the main considerations for preparing health professionals for the identification and diagnosis of LSCC.

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Upper and Lower Eyelid Malignancies: Differences in Clinical Presentation, Metastasis, and Treatment

Mukarram,

Khachemoune

2024

Arch Dermatol Res

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Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management

Cited by 4 publications

References 51 publications

Squamous cell carcinoma and basal cell carcinoma of the lips: 25 years of experience in a northeast Brazilian population

Squamous cell carcinoma and basal cell carcinoma of the lips: 25 years of experience in a northeast Brazilian population

Squamous cell carcinoma, are healthcare professionals prepared to identify it? A case report

Upper and Lower Eyelid Malignancies: Differences in Clinical Presentation, Metastasis, and Treatment

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