Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability

Tam, Elisa M. S.; Liu, Zhen; Lam, TP; Ting, Terry; Cheung, Gordon; Ng, Benjamin; Lee, Simon K M; Qiu, Yong; Cheng, Jack C. Y.

doi:10.1097/brs.0000000000001376

Cited by 47 publications

(57 citation statements)

References 42 publications

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“…In participants who had a BMI of <18.5 kg/m 2 , the prevalence of AIS showed a correlation with BMI; the OR increased up to 1.908 in women. Tam et al [15] reported that lower body mass showed a causal association between low BMI and AIS occurrence. Similar results were observed in another study, in which the mean BMI was 18.6 kg/m 2 in AIS and 19.8 kg/m 2 in controls among adolescents [27].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, low body mass index (BMI) has been reported to have greater effects on the prevalence [15] and severity of AIS [16]. The Cobb angle in the AIS population was shown to be negatively correlated with body weight [17].…”

Section: Introductionmentioning

confidence: 99%

“…The Cobb angle in the AIS population was shown to be negatively correlated with body weight [17]. One of the mechanisms underlying the association between low BMI and scoliosis is altered leptin bioavailability [15,18]. As BMI can be evaluated through school screening, early detection of and intervention for scoliosis could delay disease progression among those in the low BMI group.…”

Section: Introductionmentioning

confidence: 99%

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Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Kim

Uhm

Chae

et al. 2020

Asian Nursing Research

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Scoliosis is a common musculoskeletal problem in adolescents. This study aimed to identify the prevalence of adolescent idiopathic scoliosis (AIS) and its associated factors among Korean adolescents. The prevalence of thin individuals among students with AIS was compared based on body mass index (BMI) classifications. Methods: This study was a secondary data analysis and used the 2016 Korean National Health Examination for School Students data. Data from 16,412 students were analyzed using descriptive statistics, Chi-square tests, and logistic regression analysis. Results: The prevalence of AIS was higher in women (3.8%) than in men (1.6%), and a higher school year was a risk factor for AIS in both sexes. In woman adolescents, scoliosis was associated with thinness; however, the risk of AIS was inversely associated with overweight/obesity in both sexes. The prevalence of thin woman students with scoliosis differed based on the criteria used: 3.3% by the World Health Organization criteria and 14.3% by the International Obesity Task Force criteria. Conclusion: The prevalence of thin students with scoliosis could increase by up to four times depending on the BMI criteria. For early screening of thin people at risk of AIS among female students, the criterion of International Obesity Task Force should be used as it is more permissive of thinness. This is also because of the underestimation of AIS prevalence when using the BMI Z score of the World Health Organization cutoff.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Kim

Uhm

Chae

et al. 2020

Asian Nursing Research

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“…Several studies have linked relatively high BMI with earlier menarche, and low BMI with delayed menarche [ 34 - 36 ]. Interestingly, low BMI has also been found to be associated with AIS [ 15 , 26 , 37 ], as well as abnormal levels of leptin - a hormone known to play a role in fat regulation and the onset of puberty [ 37 - 39 ].…”

Section: Risk Factorsmentioning

confidence: 99%

Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present

Fadzan¹,

Bettany‐Saltikov²

2017

TOORTHJ

110

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Adolescent idiopathic scoliosis is one of the most common spinal deformities, yet its cause is unknown. Various theories look to biomechanical, neuromuscular, genetic, and environmental origins, yet our understanding of scoliosis etiology is still limited. Determining the cause of a disease is crucial to developing the most effective treatment. Associations made with scoliosis do not necessarily point to causality, and it is difficult to determine whether said associations are primary (playing a role in development) or secondary (develop as a result of scoliosis). Scoliosis is a complex condition with highly variable expression, even among family members, and likely has many causes. These causes could be similar among homogenous groups of AIS patients, or they could be individual. Here, we review the most prevalent theories of scoliosis etiology and recent trends in research.

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“…In addition to greater height, girls with scoliosis also usually have lighter body mass than normal. Studies by Brazolino et al (2015) and Tam et al (2016) showed that adolescents with scoliosis had a lower body mass than normal. A 5-year cohort study by Clark et al (2014) has proven the effect of scoliosis on body mass.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Scoliosis in Elementary School Students Aged 8-11 Years

Haryono

Prastowo

2019

FU Phys Ed Sport

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Adolescent idiopathic scoliosis (AIS) is a spinal abnormality commonly found in children and adolescents with a prevalence rate of 0.5-5.2%. Data on scoliosis in Indonesia is yet to be available. Our study was aimed at screening and comparing school children with normal posture and with suspected scoliosis (SS). 1059 elementary school students (477 boys, 582 girls) from grade 3 to grade 6 in Jakarta participated in this study. Body mass and height were measured according to the standard technique. Axial rotation of the spine was measured using a scoliometer. Results were classified into two groups: normal if the axial rotation angle was <5° and scoliosis was suspected if the angle was ≥5°. An independent t-test was used to analyze anthropometric differences between the normal and SS group. Statistical significance was set at p<0.05. 74 (7%) of the 1059 students were SS, consisting of 24 (5 %) boys and 50 (8.6 %) girls (OR 1.98, P=0.004). Students at the age of 10 had the highest incidence of scoliosis (27 or 10.1%). Girls with SS were significantly taller and with lower BMI values (138.6 cm vs 134.6 cm, p=0.014; 16.95 kg/m2 vs 18.50 kg/m2, p=0.028). The scoliosis rate in elementary students in Jakarta was about 7 % with higher prevalence in girls.

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Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability

Abstract: 4.

Cited by 47 publications

References 42 publications

Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present

Prevalence of Scoliosis in Elementary School Students Aged 8-11 Years

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