Lower numbers of mechanoreceptors in the posterior cruciate ligament and anterior capsule of the osteoarthritic knees

Çabuk, Haluk; Çabuk, Fatmagül Kuşku; Tekin, Ali Çağrı; Dedeoğlu, Süleyman Semih; Çakar, Murat; Büyükkurt, Cem Dinçay

doi:10.1007/s00167-016-4221-z

Cited by 14 publications

(26 citation statements)

References 31 publications

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“…In accord with Cabuk et al [12] , Moraes et al [8] similarly showed there is indeed a distinct difference between the characteristics of the hip joint mechanoreceptors among those with and without hip joint osteoarthritis, suggesting that the disease is associated with changes in the hip joint proprioceptive pathways. Although the findings were hard to interpret, this group showed that when the densities of the nerve endings at the hip were examined with regard to those with arthrosis and those without arthrosis, the mechanoreceptors of those without arthrosis were found to be more pronounced.…”

Section: Rationale Favoring the Role Of Impaired Proprioception In Ossupporting

confidence: 58%

“…In accord with this theory, Wodowski et al [11] concluded proprioceptive mechanoreceptors serving the joint are hence of paramount importance when trying to fully comprehend the origin of the functional problems of the osteoarthritis patient, as well as the disease itself. Cabuk et al [12] similarly agreed that impaired proprioception was undoubtedly a possible local mediating factor in both the onset and progression of osteoarthritis based on a study of cadavers with and without knee osteoarthritis. While this was not an in vivo study, the fact that this group found the numbers of mechanoreceptors in cases with knee osteoarthritis to be low in the posterior and anterior cruciate ligaments of 30 specimens extracted from human subjects with the disease when compared to those extracted from human cadavers with no osteoarthritis damage of the knee is hard to ignore.…”

Section: Rationale Favoring the Role Of Impaired Proprioception In Osmentioning

confidence: 89%

“…According to Collier et al [24] , seeking more precise information on variables that influence proprioception, and identifying patients with osteoarthritis likely to have poorer proprioception than desired from the earliest point in time, may prove especially valuable to both clinicians and patients, especially if surgery is contemplated. Indeed, sufficient research shows this information concerning an osteoarthritic patient's proprioceptive capacity is not merely academic, but should be intensively sought, because this, rather than radiographic assays alone, could have tremendous far reaching implications in the context of preventing and/or attenuating the disability associated with the Yet, not all authors support a role for poor proprioception in the genesis of osteoarthritis and its pathology [21] , even though poor proprioception may increase the risk for osteoarthritis or heighten its progression [2,17,34] and may foretell the development of osteoarthritis [12,52] . Indeed, no firm conclusions for purposes of intervening to prevent or reduce osteoarthritis disability attributable to poor proprioception can be forthcoming at this time, despite findings by some of defects in the ability to perceive joint angular positions accurately in response to passive or active movement cues in the absence of vision, as well as deficits in motion detection or both [2,26,27,89] .…”

Section: Movement Sensementioning

confidence: 99%

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Osteoarthritis and Proprioception: What Does the Literature Reveal?

Marks¹

2017

International Journal of Orthopaedics

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to heighten or normalize joint proprioception in symptomatic cases. METHODS: All English language peer reviewed published data pertaining to the topic of osteoarthritis and proprioception were sought. Pertinent clinical studies as well as intervention studies on this topic were then reviewed systematically with respect to their findings and study conclusions and reported in narrative form. RESULTS: Although a considerable number of studies published over the last 45 years were found to support a role for impaired proprioception in the pathology of osteoarthritis, this conclusion is not universal. Moreover, even though many forms of intervention can heighten proprioception, these interventions do not always result in the desired proprioceptive improvements, especially in the presence of severe osteoarthritic dysfunction. CONCLUSIONS: Further research to more definitively examine the influence of proprioception in the osteoarthritis disability cycle, and at what point intervention may be more useful than not, using agreed upon terminology, methodology, outcome attributes, and careful sampling, is indicated.

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Section: Rationale Favoring the Role Of Impaired Proprioception In Ossupporting

confidence: 58%

Section: Rationale Favoring the Role Of Impaired Proprioception In Osmentioning

confidence: 89%

Section: Movement Sensementioning

confidence: 99%

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Osteoarthritis and Proprioception: What Does the Literature Reveal?

Marks¹

2017

International Journal of Orthopaedics

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“…These signals offer the cognitive perception of the strength, positioning, movement, speed and direction to which the joint is submitted, contributing indispensablely to joint homeotasis. [1][2][3] Osteoarthrosis (OA) is marked by capsuloligamentous laxity, loss of articular cartilage, bone deformity and limb misalignment, factors that strongly influence the loss of proprioceptive sensitivity. It is also observed the decline in proprioceptive capacity with the aging process, which also has an important relevance when observing the degenerative joint disease, characteristically incident in older age groups.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Neural Elements in Posterior Cruciate Ligament: Comparison Between Healthy Knees and With Primary Osteoarthrosis

et al. 2021

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Objective: To quantify the neural elements in the posterior cruciate ligament (PCL) in healthy knees and with primary osteoarthrosis (OA). Methods: In two groups with OA, one of cadavers and another of individuals, the area of neural elements identified in histological sections of PCL with anti-S100 immunohistochemistry was quantified. Results: The overall mean area of the neural elements was 0.96% ± 0.67%, with the value in the cadaver group of 1.02% ± 0.67% and in the OA group of 0.80% ± 0.64%, with a significant statistically difference (p = 0.001). No correlation was observed between neural element quantification and the age of the individuals (p > 0.05). There was no difference in the quantification of neural elements between the sexes in the cadaver group (p = 0.766), but in the OA group there was a statistically significant reduction in males (p = 0.003). Also, in the osteoarthrosis group there was no difference in the quantification of neural elements in the knees with varus or valgus alignment (p = 0.847). Conclusion: There was a decrease in neural element quantification in PCL of individuals affected by OA in relation to non-arthritic individuals, with this quantification not related to age or with the axis of the lower limb. However, this quantification is not related to age or the axis of the lower limb. Level of Evidence III, Case control study.

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“…Several previous studies have demonstrated that mechanoreceptors are found in the subsynovial layer as well as near the femoral and tibial insertion sites of the anterior cruciate ligament (ACL). 5,8,18 However, few studies have evaluated whether these receptors are present in the remnants of ruptured PCLs.…”

mentioning

confidence: 99%

Mechanoreceptors in Remnant Posterior Cruciate Ligament and Achilles Tendon Allografts After Remnant-Preserving Posterior Cruciate Ligament Reconstruction: Hematoxylin-Eosin and Immunohistochemical Assessments

et al. 2020

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Background: Mechanoreceptor is a subtype of somatosensory receptor. It conveys extracellular stimuli through intracellular signal conduction via mechanically gated ion channel. It conveys not only kinetic stimuli but also pressure, stretching, touch, and even sound wave. Few studies have determined whether mechanoreceptors are present in Achilles tendon allografts used during remnant-preserving posterior cruciate ligament (PCL) reconstruction (PCLR). Purpose/Hypothesis: The purpose was to investigate whether mechanoreceptors are present in remnant tissues of the PCL and allograft tissues after PCLR. It was hypothesized that mechanoreceptors may be present in the remnant PCL tissue of the patients who underwent remnant PCLR technique. Study Design: Controlled laboratory study. Methods: Tissue samples were obtained from 14 participants who had undergone PCLR by means of Achilles tendon allografts (PCLR group) and from 4 healthy controls (control group). Among the PCLR group, 12 patients had undergone a remnant PCLR technique and the remaining 2 patients had undergone a nonremnant PCLR technique. In the PCLR group, we obtained samples during second-look arthroscopy or total knee arthroplasty after PCLR. In the control group, 4 biopsy specimens of normal PCL tissues were obtained from patients who had undergone other arthroscopic procedures. To check the presence of mechanoreceptors, immunohistochemical studies were performed on all biopsy specimens to identify neuronal and neurocytic markers by using monoclonal antibodies against glial fibrillary acidic protein, neuron-specific enolase, neurofilament, and S-100 protein. Only 1 of these markers needed to be positive to prove the presence of mechanoreceptors. Results: Neural tissue analogs, confirmed to be mechanoreceptors with monoclonal antibodies by the Ultraview DAB detection kit, were found in all specimens obtained from the control group. Mechanoreceptors were not found in the allograft specimens. However, remnant PCL tissues were found to have mechanoreceptors in 11 of 12 samples (91.7%). Conclusion: The results demonstrate that Achilles tendon allografts lack mechanoreceptors. This study can be used as histological evidence to support the advantage of remnant-preserving techniques for PCLR because they preserve proprioception. Clinical Relevance: To preserve proprioception, which leads to better functional outcome, using the remnant technique is a better procedure for PCL reconstruction.

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Lower numbers of mechanoreceptors in the posterior cruciate ligament and anterior capsule of the osteoarthritic knees

Abstract: Prognostic study, Level I.

Cited by 14 publications

References 31 publications

Osteoarthritis and Proprioception: What Does the Literature Reveal?

Osteoarthritis and Proprioception: What Does the Literature Reveal?

Quantification of Neural Elements in Posterior Cruciate Ligament: Comparison Between Healthy Knees and With Primary Osteoarthrosis

Mechanoreceptors in Remnant Posterior Cruciate Ligament and Achilles Tendon Allografts After Remnant-Preserving Posterior Cruciate Ligament Reconstruction: Hematoxylin-Eosin and Immunohistochemical Assessments

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