Lower or higher HDL-C levels are associated with cardiovascular events in the general population in rural China

Yu, Shasha; Guo, Xiaofan; Li, Guang Xiao; Yang, Hongmei; Zheng, Liqiang; Sun, Yingxian

doi:10.1186/s12944-020-01331-6

Cited by 15 publications

(13 citation statements)

References 36 publications

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“…Although HDL-C has been regarded as a divine messenger in reducing cardiovascular risk, recent studies show that cardiovascular events occur at a higher incidence in subjects with both low and high HDL-C concentrations. Thus, maintaining HDL-C levels within the normal range might be a better option in preventing the development of cardiovascular disorders during post-menopause (Barter and Genest 2019;Yu et al, 2020). However, Mirhosseini et al (2018) et al, in their meta-analysis, concluded that vitamin D administration increases HDL-C and reduces LDL-C, TC and TG, and thus further research on this topic is needed (Mirhosseini et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

Liu

Zhu

et al. 2021

Front. Mol. Biosci.

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Background and Aim: It is known that hyperlipidemia and low vitamin D level are risk factors associated with cardiovascular disease (CVD). However, the effect of vitamin D administration on lipid profiles in postmenopausal women remains unclear. This study aims to evaluate the effect of vitamin D on lipid profiles in postmenopausal women based on meta-analysis and systemic review.Methods: The literature search was performed in multiple databases (Scopus, PubMed/Medline, Web of Science, and Embase) from 1997 to 2021. The statistical analysis was performed using the Stata software version 14 (Stata Corp. College Station, Texas, United States). The effects of vitamin D administration of the lipid profiles, including Triacylglycerol (TG), LDL-Cholesterol (LDL-C), HDL-Cholesterol (HDL-C), and Total Cholesterol (TC) were evaluated by the Der Simonian and Laird random effects model. The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated.Results: The level of TG changed significantly by −3.76 mg/dl (CI: −6.12 to −1.39, p = 0.004) and HDL-C by 0.48 mg/dl (CI: −0.80 to −0.15, p = 0.004) in vitamin D administration group [11 eligible trials (placebo = 505 participants, vitamin D intervention = 604 participants)] compared to the control group in the postmenopausal women. Taking into account this comparison between groups, in contrast, the level of LDL-Cholesterol (LDL-C) (WMD: 0.73 mg/dl, 95% CI: −1.88, 3.36, p = 0.583) and TC (WMD: 0.689 mg/dl, CI: −3.059 to 4.438, p = 0.719) did not change significantly.Conclusion: In conclusion, the vitamin D administration in postmenopausal women, decreased the concentrations of TG, and HDL-C, but have no effects on LDL-C and TC.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

Liu

Zhu

et al. 2021

Front. Mol. Biosci.

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“…15 Similarly, Sun et al found that, in the general Chinese adults, the relation of HDL-C and allcause mortality was U-shaped and that HDL-C≥80 mg/dl was significantly correlated with greater risk of all-cause death. 20 Another study using data from the NHANES 1999-2010 showed that extremely high (≥100 mg/dL) or low (<30 mg/dL) levels increased risk of all-cause deaths and deaths from coronary heart disease and stroke in American adults, but the results were not stratified by hypertension status. 30 Among the elderly, Mao, et al 31 found that HDL-C <61 mg/dL was related to a 18% higher all-cause mortality risk and HDL-C >87 mg/dL increased the risk by 56% compared with the group with HDL-C concentrations ranging from 61 to 87 mg/dL.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17][18][19] In addition, a cohort study from China found that both lower and higher HDL-C were associated with increased risk of CVDs in the general rural China population, but results for cardiovascular mortality were not significant. 20 In patients with type 2 diabetes, participants with relatively high HDL-C concentration had higher risk of CVDs and all-cause mortality. 21 No significant association between HDL-C and all-cause mortality was found in some other studies.…”

Section: Introductionmentioning

confidence: 99%

<p>U-Shaped Association of High-Density Lipoprotein Cholesterol with All-Cause and Cardiovascular Mortality in Hypertensive Population</p>

Chen¹,

Liu²,

Liu³

et al. 2020

RMHP

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Purpose: Whether the paradox of high-density lipoprotein cholesterol (HDL-C) and elevated mortality risk extends to hypertensive patients is unclear. We aimed to investigate the association between HDL-C and all-cause and cardiovascular disease mortality in adults with hypertension. Methods: In the National Health and Nutrition Examination Surveys, 11,497 hypertensive participants aged ≥18years old and examined at baseline between 1999 and 2014 were followed up until December 2015. We categorized the HDL-C concentration as ≤30, 31-40, 41-50, 51-60 (reference), 61-70, >70 mg/dL and examined their associations with all-cause and cardiovascular mortality, respectively. Multivariate Cox regression was used to calculated hazard ratio (HR) and 95% confidence interval (CI) for mortality risk. Results: During follow-up (median: 9.2 ± 3.8 years), 3012 deaths and 713 cardiovascular deaths were observed. In the restrictive cubic curves, associations of HDL-C levels and allcause and cardiovascular mortality were detected to be U-shaped. After multivariable adjustment, HRs for all-cause mortality were for the lowest HDL-C concentration (≤30 mg/dL) 1.29 (95% CI, 1.07-1.56) and the highest (>70 mg/dL) 1.20 (1.06-1.37), comparing with the reference group. For cardiovascular mortality, HRs were 1.31 (0.83-1.48) and 1.09 (0.83-1.43), respectively. Similar results were obtained in subgroups stratified by age, gender, race, and taking lipid-lowering drugs. The lowest all-cause mortality risk was observed at HDL-C 66 mg/dL (concentration) and 51-60 mg/dL (range). Conclusion: Both lower and higher HDL-C concentration appeared to be associated with higher mortality in hypertensive population. Further investigation is warranted to clarify the underlying mechanisms.

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“…In this study, the overall obesity affected the third of Tunisian women and the abdominal obesity concerned almost the half, with a decreasing trend with HDL-C levels. The negative associations between obesity and HDL-C have long been reported and were attributed to the potential role of HDL-C or ApoA-I on adipose tissue content regulation (47,48). Hypertension is a well-established risk factor for CVD and is strongly associated with dyslipidemia, a group of metabolic derangements including low HDL-C levels.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of high HDL-Cholesterol and its Associated Factors Among Childbearing Age Tunisian women: A Cross-Sectional Study

Cherifa¹,

Ati

Doggui

et al. 2021

Preprint

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Background: The protective role of high HDL-C against cardiovascular risk has been questioned recently. Due to the increasing trend of CVD in Tunisia, this study aimed to determine the prevalence of high HDL-C and its associated factors in childbearing age Tunisian women. Methods: A cross-sectional survey was conducted among a subsample of 1689 women, aged 20 to 49 y in the Great Tunis region. Data on socio-demographic and lifestyle factors were collected by a questionnaire. Overall adiposity was assessed by BMI. All biological variables were assayed in blood samples coated with EDTA by enzymatic methods. Stata software (2015) was used for data management and statistical analysis. Results: High HDL-C values were recorded in 26.6% of selected women. After adjustment for all socio-demographic and lifestyle factors, age, hypertension and smoking were negatively associated with high HDL-C levels while family history of cancer was positively associated with high HDL-C in women. Conclusions: Additional investigation on the relationship between high HDL-C and cancer risk should be performed due to controversial results.

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Lower or higher HDL-C levels are associated with cardiovascular events in the general population in rural China

Cited by 15 publications

References 36 publications

Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

<p>U-Shaped Association of High-Density Lipoprotein Cholesterol with All-Cause and Cardiovascular Mortality in Hypertensive Population</p>

Prevalence of high HDL-Cholesterol and its Associated Factors Among Childbearing Age Tunisian women: A Cross-Sectional Study

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