Lower plasma pantoprazole level predicts <i>Helicobacter pylori</i> treatment failure in patients with type 2 diabetes mellitus

Sapmaz, Ferdane; Kalkan, İsmail Hakkı; Süslü, İncilay; Demirci, Hüseyin; Atasoy, Pınar; Güliter, Sefa

doi:10.1111/1751-2980.12272

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…The main characteristics of the studies included were shown in Table 1. In all studies included, 11 prospective studies compared the H. pylori eradication rate in diabetes and non‐diabetes 29‐39 . Eleven retrospective studies compared the proportion of diabetes and other clinic factors (age, gender, smoking, drinking, overweight, peptic ulcer disease, blood pressure, and history of NSAIDS) in groups failed and succeed in H. pylori eradication 40‐50 .…”

Section: Resultsmentioning

confidence: 99%

“…Eleven retrospective studies compared the proportion of diabetes and other clinic factors (age, gender, smoking, drinking, overweight, peptic ulcer disease, blood pressure, and history of NSAIDS) in groups failed and succeed in H. pylori eradication 40‐50 . Four studies further compared the level of HbA1c in diabetics failed and succeed in H. pylori eradication 30,35,37,49 . Two studies compared the Clarithromycin resistance between diabetics and non‐diabetics 32,39 .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two studies were included in these part of meta‐analysis, included 11 case‐control studies 29‐39 and 11 cohort studies 40‐50 enrolling in 5466 participants. Among them, three studies were split into two part to be included, 33,36,48 according to their group design.…”

Section: Resultsmentioning

confidence: 99%

“…Several mechanisms might play a role in the poor eradication rate of H. pylori in T2DM: (1) The absorption, distribution, and excretion of drugs might be affected by diabetes and its complications 58‐60 . The study by Sapmaz et al 37 indicated that type 2 diabetic patients had lower plasma pantoprazole levels than the non‐diabetic controls, and the level of pantoprazole levels was associated with the treatment result; (2) People with diabetes are more susceptible to bacterial infections, these cause a higher risk of antibiotic exposure and resistance, which was also proved by our findings that the clarithromycin resistance rate in diabetics was significantly higher than that normal control (Figure ). This might be a reason for the poor performance of clarithromycin containing therapeutic regimes in diabetes; (3) Hyperglycemic state might impair the immune system, which might affect the treatment of H. pylori 61‐63 .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

et al. 2021

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Background and Aims Previous studies have revealed the association between Helicobacter pylori (H. pylori) and diabetes mellitus, but conflicts still exist. The present study tried to investigate the underlying link between these two diseases by making comprehensive analyses of the impact of diabetes on H. pylori eradication and the influence of H. pylori eradication on diabetes. Methods We systematically searched relevant studies from PubMed, Cochrane Library, Web of Science, and Embase updated to April 23, 2020. Studies examining the association between H. pylori eradication and diabetes were included. Pooled odds ratio (OR) and weighted mean differences (WMD) were calculated for different results. Results Among the 2125 retrieved studies, 36 studies were included. Patients with type 2 diabetes mellitus (T2DM) have higher risk of H. pylori eradication failure than the non‐diabetic one (OR = 2.59, 95% CI 1.82–3.70). Body mass index (BMI) was identified as a major factor affecting the efficacy of H. pylori eradication in diabetics, and better glycemic control was also found in eradication succeed patients (WMD: 0.51, 95% CI 0.20–0.81). Moreover, after eradication of H. pylori, improvement of HbA1c was proved (WMD = −0.33, 95% CI −0.65 to −0.02) in T2DM. Conclusion A higher risk of H. pylori eradication failure in T2DM was confirmed, and it was associated with BMI and glycemic control. Moreover, we also provided evidence that H. pylori eradication could improve glycemic control in patients with T2DM, which indirectly reflect the interaction between H. pylori and the diabetes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

et al. 2021

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Ten days of levofloxacin-containing concomitant therapy can achieve effective Helicobacter pylori eradication in patients with type 2 diabetes

Yang

et al. 2017

Annals of Medicine

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Ten days of levofloxacin-containing concomitant therapy is an effective and well-tolerated treatment to eradicate H. pylori infection for T2DM patients. Key messages Ten days of levofloxacin-containing concomitant therapy is well tolerated and superior to clarithromycin-containing sequential therapy for first-line H. pylori eradication in patients with type 2 diabetes. Clarithromycin resistance to H. pylori is the main factor associated with eradication failure in clarithromycin-containing sequential therapy in diabetic patients.

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Helicobacter pylori Eradication Rate in Patients with Diabetes

Yoo

Cho

et al. 2017

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: The prevalence of diabetes mellitus is increasing. Little is known about the difference in Helicobacter pylori eradication rates between diabetic patients and non-diabetics. The aim of this study was to compare the eradication rate between diabetic and non-diabetic patients. Materials and Methods:The medical records of patients who received a proton pump inhibitor (PPI)-based eradication therapy between 2012 and 2015 were retrospectively reviewed. All the patients underwent endoscopic biopsy to confirm H. pylori infection. Successful eradication was confirmed by using the 13 C-urea breath test, biopsy, or rapid urease test, which was performed at least 4 weeks after the end of eradication therapy. Results: A total of 1,402 patients were included. The eradication rate was 74.3% (1,041/1,402; 95% CI, 72.0∼76.5%). Excluding 151 patients who were confirmed to have no diabetes, 182 diabetic and 1,069 non-diabetic patients were compared. No significant difference (P=0.667) in eradication rate with PPI-amoxicillin-clarithromycin therapy was found between the diabetic (75.8%, 138/182; 95% CI, 69.6∼82.0%) and non-diabetic groups (74.0%, 791/1,069; 95% CI, 71.4∼76.6%). Peptic ulcer was much more common in the diabetic group than in the non-diabetic group (67.0% vs. 57.9%, P=0.038). Conclusions: The H. pylori eradication rate with PPI-based triple therapy in the diabetic patients was probably not different from

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Lower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitus

Abstract: Type 2 diabetic patients had lower PPL than the non-diabetic controls, which led to their lower H. pylori eradication rates.

Cited by 3 publications

References 26 publications

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

Ten days of levofloxacin-containing concomitant therapy can achieve effective Helicobacter pylori eradication in patients with type 2 diabetes

Helicobacter pylori Eradication Rate in Patients with Diabetes

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