Lower platelet count in healthy centenarians correlates with dispersion of the QT interval

Gangemi, Sebastiano; Basile, Giorgio; Merendino, Rosaria Alba; Balbo, Claudia Lo; Mento, Antonella; Nicita-Mauro, Vittorio; Franceschi, Claudio; Romano, Mario R.

doi:10.1007/bf03324547

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…The clinical relevance of the difference in platelet counts between the subjects with and without A-allele should be further established, but even such a minor difference within a reference range of platelet counts has been debatable regarding the etiopathology of diseases such as CVD. 6,11,12 Therefore, the significant association between the FTO gene polymorphisms and platelet counts found in the present study may provide new insights into the areas related to FTO gene research.…”

Section: Discussionsupporting

confidence: 56%

FTO Gene Polymorphisms and Platelet Counts in a General Japanese Population

Kotani

Fujiwara

Tsuzaki

et al. 2012

Journal of Investigative Medicine

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The fat mass and obesity-associated (FTO) gene has recently attracted attention as one of the obesity-related genes. Obesity-related gene polymorphisms may be associated with the development of atherothrombosis in relation to platelets. The present study investigated the association between FTO gene polymorphisms (rs1558902, T/A) and hematological parameters, in particular the platelet counts. Anthropometric, hematological, and biochemical parameters, in addition to genotyping by an allele-specific DNA assay, were measured in 209 asymptomatic community-dwelling Japanese subjects (male/female: 80/129; mean age, 65 years; mean [SD] body mass index, 24.0 [3.0] kg/m). The subjects with the A-allele (n = 73) showed significantly higher platelet counts than those without the A-allele (mean [SD], 237 [58] vs 217 [57] × 10/L, P < 0.05). Even when multiple-adjusted analyses were performed, the platelet counts continued to differ significantly and independently of other variables, including obesity-related parameters such as the index of insulin resistance or high-sensitivity C-reactive protein, between the subjects with and without the A-allele. The FTO gene polymorphisms may be associated with the minor but significant modulation of platelet counts in this population.

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Section: Discussionsupporting

confidence: 56%

FTO Gene Polymorphisms and Platelet Counts in a General Japanese Population

Kotani

Fujiwara

Tsuzaki

et al. 2012

Journal of Investigative Medicine

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“…Previous studies did not show any significant change in QTd with age in a healthy older population. In a preceding study, we have demonstrated that centenarians had a QTd value of 49.3 8 23.51 ms, which did not significantly differ from that observed both in younger and older controls [12] . These results lead to the speculation that the preservation of normal QTd values may protect centenarians against cardiovascular events, especially ventricular arrhythmias and sudden death.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Changes in Centenarians: A Study on 42 Subjects and Comparison with the Literature

et al. 2011

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Background: Aging is associated with extensive and pervasive changes in cardiovascular structure and function, which may result in electrocardiographic alterations. The typical modifications seen in an electrocardiogram (ECG) in elders are: prolonged PR and QT intervals, QRS left-axis deviation and microvolt T wave. Several studies have included elderly people, but not long-living elderly and centenarians in particular who represent an increasing part of the population. Objective: The aim of this study was to investigate the electrocardiographic findings in a population of centenarians and to compare the results with the few studies present in the literature. Methods: We analyzed 42 healthy centenarians (12 males, 30 females; average age 101.43 ± 1.80 years) living in Messina, a municipality of Eastern Sicily, in Italy. They were clinically and functionally evaluated. All ECGs were analyzed by a single observer blind to clinical data. We assessed survival by phone recall. Results: PR interval mean duration was 190 ± 3.3 ms, QRS 90 ± 1.4 ms, QTc interval mean duration was 370 ± 3.5 ms. Entirely normal ECG recordings were found in 7 centenarians (16.6%). The most frequently observed abnormalities included left-axis deviation and left anterior hemiblock in 16 centenarians (38.09%), left ventricular hypertrophy and aspecific ST-T wave abnormalities in 13 subjects (30.95%). We found no statistically significant differences between men and women. The mean age at death was 102.44 ± 2.45, and we did not find significant differences in age at death in long-living elderly in relation to different electrocardiographic findings. Comparing our results with two previous studies in the literature, the first conducted in Switzerland [Cornu: Rev Med Suisse Rom 1979;99:107–113] and the second in Nebraska [Lakkireddy et al.: Am J Cardiol 2003;92:1249–1251], we found a higher frequency of left ventricular hypertrophy that was compatible with the prevalence of hypertension in our centenarians (33.3%). Moreover, we did not find left bundle branch block, and the frequency of premature beats was remarkably less than that observed in the Swiss and US studies. Conclusions: Considering the increasing rate of centenarians, we believe that the results of the present study on electrocardiographic changes in centenarians may also be useful in clinical practice.

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“…It was found that controlling for the effect of age and gender, subjective health was not significantly related to any biomarkers, whereas ADL independence was related to a lower level of platelet (r D ¡.26, p D .018) and a higher level of albumin (r D .27, p D .014). Previous studies on centenarians revealed that higher albumin level was related to better functional health (Gondo et al, 2006) and higher levels of hemoglobin and albumin had a significant positive effect on subjective health (Cho et al, 2011), while lower platelet count was related to lower risk of cardiovascular events (Gangemi et al, 2004). Since the current study is interested in the correlates of a multidimensional SA construct, the patterns and pathways were not elaborated through which biomarkers including albumin and platelets manifest themselves in physical and functional health per se.…”

Section: Fundingmentioning

confidence: 93%

Successful aging among Chinese near-centenarians and centenarians in Hong Kong: a multidimensional and interdisciplinary approach

Cheung

Lau

2015

Aging & Mental Health

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Lower platelet count in healthy centenarians correlates with dispersion of the QT interval

Abstract: We hypothesize that a reduced number of platelets and the maintenance of normal QTd may contribute to extreme longevity and protect centenarians from cardiovascular events.

Cited by 6 publications

References 16 publications

FTO Gene Polymorphisms and Platelet Counts in a General Japanese Population

FTO Gene Polymorphisms and Platelet Counts in a General Japanese Population

Electrocardiographic Changes in Centenarians: A Study on 42 Subjects and Comparison with the Literature

Successful aging among Chinese near-centenarians and centenarians in Hong Kong: a multidimensional and interdisciplinary approach

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