Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: The Beijing Osteoarthritis Study

Zhang, Yuqing; Xu, Li; Nevitt, Michael C.; Niu, Jingbo; Goggins, Joyce; Aliabadi, Piran; Yu, Wei; Lui, Li‐Yung; Felson, David T.

doi:10.1002/art.10928

Cited by 121 publications

(113 citation statements)

References 25 publications

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“…Zhang et al [28] compared the prevalence of hand OA in Chinese in China to that of white people living in the United States, and found that only 44.5% of men and 47.0% of women had radiographic hand OA in China, but that 75.2% of men and 85.0% of women had radiographic hand OA in the United States. Yoshida et al [26] also concluded that the prevalence of hand OA in Japanese patients was lower than in white patients.…”

Section: Discussionmentioning

confidence: 99%

“…Yoshida et al [26] also concluded that the prevalence of hand OA in Japanese patients was lower than in white patients. Zhang et al [28] considered that the low prevalence of hand OA in the Chinese was attributable to a lower prevalence of diseasesusceptibility genes in Chinese patients, whereas Yoshida et al [26] suggested that genetic background and environmental or cultural (lifestyle) factors probably explained the low prevalence of OA in Japanese patients.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have found that radiographic hand OA has a high prevalence among the elderly, ranging from 13% to 47% in Asian populations [26,28] and 80% to 94% in white populations [2,25,27].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Digit-related Radiographic Osteoarthritis of the Hand on Grip-strength and Upper Extremity Disability

Lee

Paik

Lim

et al. 2012

Clinical Orthopaedics &Amp; Related Research

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Background Interpreting the impact of hand osteoarthritis (OA) on hand function is complicated owing to the multiple digits and joints in the hand. Questions/purpose We determined the impact of digitrelated radiographic OA on hand function in patients 65 years or older.Methods We evaluated hand radiographs in 196 men and 182 women older than 65 years without shoulder or elbow pain who participated in the Korean Longitudinal Study on Health and Aging. Using the Kellgren and Lawrence criteria, we graded the 15 joints in each hand from 0 to 4 for OA, and evaluated hand function by measuring DASH scores and grip and pinch strength of dominant hands. We performed multiple linear regression analyses to evaluate associations between hand functions and the sum of Kellgren and Lawrence grade of each digit. Results The sums of Kellgren and Lawrence grades for thumbs and middle fingers were independently associated with grip strength, and the sums of the Kellgren and Lawrence grades for thumbs and index fingers were independently associated with pinch strength after controlling for age and sex. DASH scores were independently associated with OA of the thumb, or index or middle finger, but not with OA of the ring or small finger. Conclusions This study revealed cumulative effects of joint involvement and Kellgren and Lawrence grades of thumb and middle finger OA on grip strength, and thumb and index finger OA on pinch strength. Furthermore, OA of either of three radial digits was associated with more severe upper extremity disabilities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Digit-related Radiographic Osteoarthritis of the Hand on Grip-strength and Upper Extremity Disability

Lee

Paik

Lim

et al. 2012

Clinical Orthopaedics &Amp; Related Research

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“…Bilateral posteroanterior hand and knee radiographs were obtained using standard techniques (26,27). Each distal interphalangeal, proximal interphalangeal, metacarpophalangeal, interphalangeal, carpometacarpophalangeal, wrist, and knee joint was graded using the Framingham OA atlas for Kellgren/Lawrence (K/L) grade (0-4), largest osteophyte (grade 0-3), and joint space narrowing (JSN) (grade 0-3) (28,29).…”

Section: Radiographsmentioning

confidence: 99%

Low vitamin K status is associated with osteoarthritis in the hand and knee

Neogi

Booth

Zhang

et al. 2006

Arthritis & Rheumatism

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146

101

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Objective. Poor intake of vitamin K is common. Insufficient vitamin K can result in abnormal cartilage and bone mineralization. Furthermore, osteophyte growth, seen in osteoarthritis (OA), may be a vitamin K-dependent process. We undertook this study to determine whether vitamin K deficiency is associated with radiographic features of OA.Methods. We conducted an analysis among 672 participants (mean age 65.6 years, 358 women) in the Framingham Offspring Study, a population-based prospective observational cohort. Levels of plasma phylloquinone (the primary form of vitamin K) had previously been measured in these participants, for whom we also had bilateral hand and knee radiographs. The main outcomes were 1) prevalence ratios (PRs) of OA, osteophytes, and joint space narrowing (JSN) per quartile of plasma phylloquinone level for each joint, adjusting for correlated joints using generalized estimating equations, and 2) adjusted mean number of joints with each feature per quartile of plasma phylloquinone level. Analyses were conducted in hands and knees separately and adjusted for age, sex, body mass index, total energy intake, plasma vitamin D, and femoral neck bone mineral density.Results. The PRs for OA, osteophytes, and JSN and adjusted mean number of joints with all 3 features in the hand decreased significantly with increasing plasma phylloquinone levels (P < 0.03 for all). For example, as plasma phylloquinone levels rose, the PR for hand OA decreased from 1.0 to 0.7 (P ‫؍‬ 0.005). For the knee, only the PR for osteophytes and the adjusted mean number of knee joints with osteophytes decreased significantly with increasing plasma phylloquinone levels (PR decreased from 1.0 to 0.6, P ‫؍‬ 0.01).Conclusion. These observational data support the hypothesis of an association between low plasma levels of vitamin K and increased prevalence of OA manifestations in the hand and knee.

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“…However, the majority of surveys on the prevalence of OA have been performed in Europe and the United states [1, 3, 5, 10-13, 18, 22, 28, 30, 34, 35]. Recently, a relatively small number of population-based studies have been conducted in Asia [7,24,26,27,39,40]; therefore, racial differences in the epidemiologic characteristics of OA could be estimated in some degrees through the comparative analysis. However, most Asian population-based surveys have been limted primarily to China and Japan and have been focused on the OA of a single joint; thus, little is known about the ethnic and geographical variation of the pattern of joint distribution of OA among the same Asian populatons.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years

Cho

Morey

Kang

et al. 2015

Clin Orthop Relat Res

112

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Background Osteoarthritis (OA) is common and disabling among older patients around the world. Data exploring the prevalence and risk factors of OA are of paramount importance in establishing healthcare policies. However, few studies have evaluated these topics among Asian populations. Questions/purposes This study was conducted to determine the prevalence and risk factors of radiographic OA in the spine, shoulder, hand, hip, and knee in Koreans older than age 65 years.Methods A simple random sample (N = 1118) was drawn from a roster of elderly individuals older than age 65 years in Seongnam. Of the 1118 invited subjects, 696 (males = 298, females = 398) participated in this study (a response rate of 62%). The mean age of respondents was 72 ± 5 years (range, 65-91 years). Radiographs of the lumbar spine, shoulder, hand, hip, and knee were taken and afterward evaluated for radiographic OA. The KellgrenLawrence grading system was used for all mentioned joints, and radiographic OA was defined as Grade 2 changes or higher. The association of sex, aging, and obesity with OA in each of the mentioned joints was determined with the help of multivariate logistic regression. Results The highest prevalence of radiographic OA was seen in the spine (number of subjects with OA/number of whole population = 462 of 696 [66%]) followed by the hand (415 of [CI], 3.9-8.4; p \ 0.001) and hand OA (OR, 2.3; 95% CI, 1.6-3.1; p \ 0.001), and male sex was associated with spine OA (OR, 0.7; 95% CI, 0.5-1.0; p = 0.025). Aging was associated with radiographic OA in the spine, knee, and hand (OR per 5-year increments, 1.3 [95% CI, 1.1-1.6; p = 0.001], 1.6 [95% CI, 1.4-1.9; p \ 0.001], and 1.4 [95% CI, 1.2-1.7; p \ 0.001]), respectively) but not associated with OA in the hip and shoulder. Obesity was associated with knee OA (OR, 3.4; 95% CI, 2.4-5.0; p \ 0.001) and spine OA (OR, 1.5; 95% CI, 1.1-2.2; p = 0.014) but not with OA in other joints. Conclusions OA of the spine, hand, and knee is likely to become a major public health problem rather than shoulder and hip OA in Korea. Associations of demographic factors

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Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: The Beijing Osteoarthritis Study

Cited by 121 publications

References 25 publications

The Impact of Digit-related Radiographic Osteoarthritis of the Hand on Grip-strength and Upper Extremity Disability

The Impact of Digit-related Radiographic Osteoarthritis of the Hand on Grip-strength and Upper Extremity Disability

Low vitamin K status is associated with osteoarthritis in the hand and knee

Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years

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