Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: A population-based cohort study

Miyamoto, Akira; Kuriyama, Shinichi; Nishino, Yoshikazu; Tsubono, Yoshitaka; Nakaya, Naoki; Ohmori, Kenji; Kurashima, Koshi; Shibuya, Daisuke; Tsuji, Ichiro

doi:10.1016/j.ypmed.2006.07.016

Cited by 77 publications

(61 citation statements)

References 29 publications

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“…Prospective studies using photofluorographic methods has shown 2-fold decrease in gastric cancer mortality (relative risk, 0.52; 95% confidence interval, 0.36-0.74) between screened and nonscreened subjects (53). However, the implementation of such massive screening program in asymptomatic population is expensive.…”

Section: Discussionmentioning

confidence: 99%

Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer

Bernal¹,

Aguayo

Villarroel

et al. 2008

Clinical Cancer Research

108

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Purpose: Gastric cancer is a curable disease if diagnosed at early stage. However, most cases are diagnosed at advanced stage because of the lack of screening programs. Therefore, the identification of plasma biomarkers for early detection is necessary. Experimental Design: To search for these biomarkers, we evaluated the DNA methylation patterns of 24 genes by Methylation-specific PCR in primary tissues from 32 retrospectively collected gastric cancer cases (testing group). Correlation between methylation and gene expression was evaluated in the MKN-45 cell line after treatment with 5-aza-2 ¶-deoxycytidine. The most frequently hypermethylated genes were next evaluated in primary tissues and plasma samples from 43 prospectively collected gastric cancer cases as well as plasma samples from 31 asymptomatic age-and gender-matched controls (validation group). Results: In the testing group, 11 genes were hypermethylated in at least 50% of cases (APC, SHP1, E-cadherin, ER, Reprimo, SEMA3B, 3OST2, p14, p15, DAPK , and p16). Eight genes (BRCA1, p73, RARb, hMLH1, RIZI, RUNX3, MGMT, and TIMP3) were statistically associated with a particular variant of gastric cancer, the signet-ring cell type (P = 0.03). Seven genes (APC, SHP1, E-cadherin, ER, Reprimo, SEMA3B, and 3OST2) were next evaluated in the validation group. We confirm the high frequency of methylation in primary tumors for all seven genes. However, only APC and Reprimo were frequently methylated in pair plasma samples. In asymptomatic controls, only Reprimo was infrequently methylated in comparison with plasma from gastric cancer cases (P < 0.001). Conclusion:Our results identified specific methylation profile associated to signet-ring cell-type histology and aberrant hypermethylation of Reprimo as a potential biomarker for early detection of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer

Bernal¹,

Aguayo

Villarroel

et al. 2008

Clinical Cancer Research

108

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“…Mortality according to age and gender was assessed using National Statistical Office 2008 data (Korea National Statistical Office, 2010). The stage distribution and the survival outcomes in the unscreened population were projected on the basis of local studies (Hansson et al, 1999;Kubota et al, 2000;Dan et al, 2006;Kunisaki et al, 2006;Miyamoto et al, 2007;Nam et al, 2009). The corresponding outcomes for the screened population were projected from clinical studies conducted in Korea or Japan (Kubota et al, 2000;Han et al, 2003;Nam et al, 2009).…”

Section: Incidence and Prevalence Ratesmentioning

confidence: 99%

“…The quality of life according to gastric cancer stage was obtained from several published articles (Dan et al, 2006;Hanmer et al, 2006). The survival rate according to stage was calculated using the 5-or 10-year survival rates from a synthesis of published studies (Babazono & Hillman, 1995;Kim et al, 2000;Kunisaki et al, 2006;Miyamoto et al, 2007).…”

mentioning

confidence: 99%

Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

Chang

Park

Chung

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: There are limited data evaluating the cost-effectiveness of gastric cancer screening using endoscopy or upper gastrointestinal x-ray in the general population. Objective: To evaluate the costeffectiveness of population-based screening for gastric cancer in South Korea by decision analysis. Methods: A time-dependent Markov model for gastric cancer was constructed for healthy adults 30 years of age and older, and a deterministic sensitivity analysis was performed. Cost-utility analysis with multiple strategies was conducted to compare the costs and effects of 13 different screening alternatives with respect to the following eligibility criteria: age at the beginning of screening, screening interval, and screening method. The main outcome measurement was the incremental cost-effectiveness ratio. Results: The results revealed that annual endoscopic screening from ages 50-80 was the most cost-effective for the male population. In the females, biennial endoscopy screening from ages 50-80 was calculated as the most cost-effective strategy among the 12 screening alternatives. The most cost-effective screening strategy may be adjustable according to the screening costs and the distribution of cancer stage at screening. The limitation was that effectiveness data were obtained from published sources. Conclusions: Using the threshold of $19,162 per quality-adjusted life year on the basis of the Korean gross domestic product (2008), as suggested by the World Health Organization, endoscopic gastric cancer screening starting at the age of 50 years was highly cost-effective in the Korean population. The national recommendation for gastric cancer screening should consider the starting age of screening, the screening interval, and the screening modality.

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“…(6) The cohort studies conducted in Japan showed a significant GC mortality reduction with photofluorography screening. (5,7) In recent years, endoscopy has replaced photofluorography as the initial mass screening method in several cities in Japan. (8,9) This technique is increasingly useful for GC screening because of its high detection rate.…”

mentioning

confidence: 99%

Who participates in the gastric cancer screening and on‐time rescreening in the National Cancer Screening Program? A population‐based study in Korea

et al. 2011

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Gastric cancer (GC) screening is a major challenge in countries where the disease is highly prevalent. This study was conducted to identify the factors associated with participation in GC screening and on-time rescreening among the average-risk population in Korea. The study population was derived from the National Cancer Screening Program database. The population for this study was 22 913 618 individuals aged ‡40 years who had been invited to participate in a GC screening program from 2005 to 2006. We determined whether these individuals had attended the GC screening program and which method -an upper gastrointestinal series (UGIS) or endoscopy-they underwent. We followed the participants to determine whether they had a second GC screening after 2 years. The overall participation rate in the GC screening was 20.5%. More people underwent UGIS than endoscopy. Individuals who had been screened by endoscopy rather than UGIS were more likely to be younger, male, or those who were National Health Insurance (NHI) beneficiaries with a higher premium rate. Of those who underwent baseline screening, 59.4% participated in a rescreening program 2 years later. NHI beneficiaries with a higher premium rate were significantly more likely to be rescreened than medical aid recipients. The results from this study showed that the UGIS were more commonly used in organized GC screenings in Korea, and those who underwent UGIS were more likely to return for subsequent screening compared to those who underwent an endoscopy. (Cancer Sci 2011; 102: 2241-2247 G astric cancer (GC) is the fourth most common cancer behind lung cancer, breast cancer, and colorectal cancer, and in 2008 was the second most common cause of cancer deaths worldwide. (1) In Korea, GC is the most frequent type of cancer. (2,3) In countries where GC is highly prevalent, GC screening is offered to the average-risk population to reduce the disease burden. (4) Gastric cancer screening has shown improvements in survival rates as a result of early detection and consequently higher cure rates. (5) Therefore, many Asian countries with a high burden of GC have considered implementing GC screening for the general population. (6) Since 1960, Japan has implemented photofluorography (via an indirect upper gastrointestinal series [UGIS]) screening programs to detect GC in its early stages and prevent GC deaths. (6) The cohort studies conducted in Japan showed a significant GC mortality reduction with photofluorography screening. (5,7) In recent years, endoscopy has replaced photofluorography as the initial mass screening method in several cities in Japan. (8,9) This technique is increasingly useful for GC screening because of its high detection rate. In a study conducted in Niigata, Japan, the detection of GC by endoscopy was 2.7-4.6 times higher than that by direct or indirect UGIS. (10)(11)(12) Recently, Hosokawa et al. (13) reported an approximately 65% reduction in the GC death rate for participants screened with endoscopy. Despite this promising result, direct evidence for t...

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Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: A population-based cohort study

Cited by 77 publications

References 29 publications

Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer

Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer

Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

Who participates in the gastric cancer screening and on‐time rescreening in the National Cancer Screening Program? A population‐based study in Korea

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