Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case–control study

Pishgahi, Alireza; Dolatkhah, Neda; Shakouri, Seyed Kazem; Hashemian, Maryam; Amiri, Amin; Reihany, Morteza Delkhosh; Jahanjou, Fatemeh

doi:10.1186/s13104-019-4768-0

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Age-dependent IDD, often associated with osteoporosis-whose treatment aimed at increasing the bone mineral density includes vitamin D supplementation-have been suggested as being responsible of endplate calcification by blocking nutrient and oxygen supply in the disc [15]. Nevertheless, it was observed that subjects with deficiency or insufficiency of vitamin D were more likely to exhibit low back pain than subjects with a normal serum concentration [16][17][18], even if also in this case conflicting evidence is reported [19]. Therefore, the increasingly recognized immunomodulatory role of vitamin D [20,21] could be exploited to target the inflammatory and catabolic process in the IDD [22,23].…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants

Colombini

Luca

Cangelosi

et al. 2021

IJMS

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Vitamin D showed a protective effect on intervertebral disc degeneration (IDD) although conflicting evidence is reported. An explanation could be due to the presence of the FokI functional variant in the vitamin D receptor (VDR), observed as associated with spine pathologies. The present study was aimed at investigating—through high-throughput gene and protein analysis—the response of human disc cells to vitamin D, depending on the VDR FokI variants. The presence of FokI VDR polymorphism was determined in disc cells from patients with discopathy. 1,25(OH)2D3 was administered to the cells with or without interleukin 1 beta (IL-1β). Microarray, protein arrays, and multiplex protein analysis were performed. In both FokI genotypes (FF and Ff), vitamin D upregulated metabolic genes of collagen. In FF cells, the hormone promoted the matrix proteins synthesis and a downregulation of enzymes involved in matrix catabolism, whereas Ff cells behaved oppositely. In FF cells, inflammation seems to hamper the synthetic activity mediated by vitamin D. Angiogenic markers were upregulated in FF cells, along with hypertrophic markers, some of them upregulated also in Ff cells after vitamin D treatment. Higher inflammatory protein modulation after vitamin D treatment was observed in inflammatory condition. These findings would help to clarify the clinical potential of vitamin D supplementation in patients affected by IDD.

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Section: Introductionmentioning

confidence: 99%

High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants

Colombini

Luca

Cangelosi

et al. 2021

IJMS

View full text Add to dashboard Cite

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Evaluation of the Effectiveness of Core Stabilization Exercise and Vitamin D Intake on Pain and Functional Disability Levels in Women with Chronic Non-specific Low Back Pain

Akbarnya

Habibian

Moosavi

2020

JHC

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Background & aim: Nowadays, the prevalence of chronic low back pain is increasing in the world and vitamin D deficiency is associated with impaired neuromuscular function and chronic musculoskeletal pain. In addition, exercise therapy and selection of core stabilization exercise interventions have main roles in rehabilitation of these patients. The aim of this study was to investigate the effect of 8 weeks of core stabilization exercises and vitamin D intake on the pain and functional disability levels in women with chronic non-specific low back pain. Methods: This clinical trial study was performed by pre-test and post-test design. Initially, 48 women with chronic non-specific low back pain were selected by available sampling method and then randomly divided into control, exercise, vitamin D and exercise+vitamin D (combined) groups (12 subjects in each group). The exercise and combined groups performed 8 weeks of core stabilizing exercises. The vitamin D and combined groups received 50,000 IU vitamin D/week for 8 weeks. The severity of the pain and functional disability, before and after the interventions, were determined by visual analog scale of pain and Oswestry questionnaire, respectively. Data analysis was performed using Paired T-Test and ANOVA with the significance level of less than 0.05. Results: Eight weeks of core stabilizing exercises, vitamin D intake and the combined intervention were associated with a significant reduction (p<0.001) in pain (20.15%, 18.60% and 34.20%, respectively) and functional disability (48.35%, 44.26% and 51.81%, respectively) in women with chronic non-specific low back pain. In addition, combined intervention induced more reduction in the pain compared with two other interventions (p<0.001) Conclusion: It seems that core stabilizing exercises, vitamin D intake, and the combination intervention can reduce the pain and improve the physical function in patients with chronic low back who have low levels of vitamin D. But combined intervention is associated with greater effectiveness in reducing the pain.

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Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case–control study

Cited by 2 publications

References 31 publications

High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants

High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants

Evaluation of the Effectiveness of Core Stabilization Exercise and Vitamin D Intake on Pain and Functional Disability Levels in Women with Chronic Non-specific Low Back Pain

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