Lower serum triglyceride levels linked to more severe motor performance in Parkinson’s disease

Abstract

Introduction Emerging evidence has suggested that lipid metabolism is correlated with Parkinson’s disease (PD) onset and progression. However, the effect of lipid metabolism on motor performance in PD patients is still unknown. This study estimated the association between lipid profiles and the severity of motor performance in PD. Methods This cross-sectional study enrolled 279 idiopathic PD patients from the Department of Neurology of Beijing Tiantan Hospital from May 2016 to August 2018. Serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and apolipoprotein B (Apo-B) levels were detected in fast serum samples. Motor performance was assessed by Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III (MDS-UPDRS III) total scores and subscores in these patients. The associations of lipid profiles with motor performance were analyzed using multivariable linear regression models. Results Compared to males, females with PD exhibited significantly higher serum TC, LDL-C, HDL-C, Apo-A1, and Apo-B levels. When accounting for covariates, lower serum TG levels were significantly associated with higher MDS-UPDRS III total scores and gait/postural instability subscores. Additionally, the univariate linear regression model showed that in males with PD, serum HDL-C or Apo-A1 levels were significantly associated with tremor subscores. Conclusion Lower serum TG levels were associated with more severe motor performance in patients with PD and TG may be a potential predictive biomarker for motor performance in PD patients.

U-shaped association between triglyceride and risk of incident diabetes in normoglycemic males with NAFLD: A population-base cohort study

“…Besides, Li W et al and Jain M et al demonstrated that low serum TG levels worsened the prognosis in acute ischemic stroke [39,40] . Lower TG levels were also linked with higher hemorrhagic stroke risk in a prospective cohort study among 27,937 women [41] and more severe motor performance in Parkinson's disease [42] both of which are closely associated with diabetes [43][44][45] . Moreover, Statins, with the effect of decrease plasma TG concentration [46,47] and protective against NAFLD [48][49][50][51] and the development of liver fibrosis attributed to NAFLD [52] , has been reported to increased risk of new-onset diabetes by 12% (OR, 1.12) in an intensive-dose therapy compared with moderate-dose statin therapy [53] .…”

Association of lipid levels with motor and cognitive function and decline in Parkinson's disease

“…28 Unlike serum TG levels, serum Apo-A1, HDL-C, LDL-C and TC levels were not significantly associated with motor function, cognitive function or their deterioration in PD, which was consistent with previous research. 11,28 Thus, serum Apo-A1, HDL-C, LDL-C and TC levels do not seem to be significant indicators for assessing motor and cognitive function in PD.…”

“…10 Likewise, lower serum TG levels were associated with more severe motor performance in PD patients, indicating TG as a potential predictive biomarker for motor function. 11 Further research is needed to investigate the impact of blood lipid levels on motor and cognitive function over time. Therefore, this study aims to explore the relationship between blood lipid biomarkers and these indicators in individuals with PD.…”

“…In addition, females with PD were found to have higher serum high‐density lipoprotein cholesterol (HDL‐C) levels, potentially impacting cognitive performance 10 . Likewise, lower serum TG levels were associated with more severe motor performance in PD patients, indicating TG as a potential predictive biomarker for motor function 11 . Further research is needed to investigate the impact of blood lipid levels on motor and cognitive function over time.…”

Serum-Based Lipid Panels for Diagnosis of Idiopathic Parkinson’s Disease

“…The mechanisms by which TGs are involved in PD development and progression are unclear, but could be related to their role in neural communication, signal transduction, and cell membrane and mitochondrial functions [ 28 ]. Lower serum TG levels were associated with more severe motor performance effects in patients with PD [ 29 ]. Our findings indicate that lower TG levels might play a role in accelerating PD progression among early-stage PD individuals, and this could be a potential biomarker for monitoring the progression of the disease.…”