Lower serum zinc level is associated with higher fasting insulin in type 2 diabetes mellitus (T2DM) and relates with disturbed glucagon suppression response in male patients

Safarzad, Mahdieh; Jazi, Marie Saghaeian; Kiaei, Mohammadreza; Asadi, Jahanbakhsh

doi:10.1016/j.pcd.2023.05.008

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…found that lower serum zinc level is associated with higher fasting insulin in T2DM. 11 Not only that, but the role of copper is coming into focus. High plasma copper concentrations have been reported to mediate the formation of damaging ROS, which are associated with insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

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The association between serum copper concentration and prevalence of diabetes among US adults with hypertension (NHANES 2011–2016)

Wu,

Chen,

Kong

et al. 2024

J Cellular Molecular Medi

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The objective of this study was to examine the association between the serum copper concentration and the prevalence of diabetes among US adults with hypertension using the data from the National Health and Nutrition Examination Survey (NHANES). The study population was selected from adults aged over 20 years old in the three survey cycles of NHANES from 2011 to 2016. Logistic regression model analyses were applied to determine the independent risky effect of copper to the prevalence of diabetes. Also, a restricted cubic spline (RCS) model was performed to explore the potential nonlinear association between serum copper concentration and the prevalence of diabetes. A total of 1786 subjects (742 cases and 1044 controls) were included, and 924 were men (51.7%), and 742 (41.5%) were diabetic. Compared with non‐diabetic individuals, the concentration of serum copper in diabetic patients with hypertension was higher. After adjusting for age, sex, race, education, marital status, body mass index (BMI), family poverty income ratio (PIR), smoking, alcohol drinking, physical activity, systolic blood pressure (SBP), diastolic blood pressure (DBP), and hyperlipidemia, the highest quartile of serum copper concentration significantly increased the risk of diabetes as compared with the lowest quartile (OR: 1.38, 95% CI: 1.01–1.92, ptrend = 0.036). The results of RCS analysis showed significant non‐linear relationship between serum copper concentration and prevalence of diabetes (p‐non‐linear = 0.010). This study finds that serum copper concentration are significantly associated with risk of diabetes in hypertensive patients, which suggests copper as an important risk factor of diabetes development.

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Section: Discussionmentioning

confidence: 99%

“…Recently, there has been an increased emphasis on studying the effect of trace elements on the risk of diabetes. 11 , 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

The association between serum copper concentration and prevalence of diabetes among US adults with hypertension (NHANES 2011–2016)

Wu,

Chen,

Kong

et al. 2024

J Cellular Molecular Medi

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“…Our findings indicate a notable decrease in zinc content in the hair samples from individuals with t2DM, aligning with experimental studies that emphasize the pivotal role of zinc in glucose metabolism. Zinc is thought to be involved in insulin release mechanisms within the β-cells of the islets of Langerhans [48], gluconeogenesis [49][50][51], as well as in the regulation of tissue sensitivity to insulin [52]. Furthermore, its supplementation was suggested to have potential benefits for patients with t2DM [50,53].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score

Dziedzic,

Gąsior,

Tuzimek

et al. 2023

Biology

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Coronary artery disease (CAD) continues to be a foremost contributor to global mortality, and the quest for modifiable risk factors could improve prophylactic strategies. Recent studies suggest a significant role of zinc (Zn) and copper (Cu) deficiency in atheromatous plaque formation. Furthermore, hair was previously described as a valuable source of information on elemental burden during the 6–8 week period before sampling. The aim of this study was to investigate the possibility of correlation between the extent of CAD evaluated with the SYNergy Between PCI With TAXUS and the Cardiac Surgery (SYNTAX) score with Cu and Zn content in hair samples, as well as with the Cu/Zn ratio in a cohort of 130 patients. Our findings describe a statistically significant inverse correlation between Cu content and the Cu/Zn ratio in hair samples and the extent of CAD. In contrast, no significant correlation was found between Zn content and the extent of CAD. Considering the scarcity of existing data on the subject, the analysis of hair samples could yield a novel insight into elemental deficiencies and their potential influence on CAD extent.

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The Relationship between Levels of Zinc and Copper and Insulin Resistance in Polycystic Ovary Syndrome Patients in Homs

Alzahr,

Alwassouf

2024

Jordan j. pharm. sci.

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Objective: To investigate the association between zinc and copper levels and insulin resistance, a key pathological mechanism of Polycystic Ovary Syndrome (PCOS), and to compare these levels with those of healthy subjects in Homs. Methods: The study included 63 female patients newly diagnosed with PCOS, prior to treatment at Al-Basil Hospital in Homs, Syria, along with 25 healthy subjects of similar age. Blood samples were collected using dry tubes for laboratory measurements of zinc, copper, glucose, and insulin hormone levels. Subsequently, the HOMA-IR and QUICKI indices were calculated. Results: In the patients' group, serum zinc levels were significantly lower (p-value=0.000), and serum copper levels were significantly higher (p-value=0.000) compared to healthy subjects. Among patients with insulin resistance, serum zinc levels were significantly lower (p-value=0.004), and serum copper levels were significantly higher (p-value=0.000) compared to patients without insulin resistance. Patients without insulin resistance had significantly lower serum zinc levels (p-value=0.000) and significantly higher serum copper levels (p-value=0.000) compared to healthy subjects. There was a positive correlation between copper and HOMA-IR (r=0.572**, p-value=0.000), and a negative correlation between zinc and HOMA-IR (r=-0.865**, p-value=0.000). Conclusion: The imbalance in zinc and copper levels appears to play a role in the development of PCOS, both in relation to insulin resistance and potentially as an independent factor.

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Lower serum zinc level is associated with higher fasting insulin in type 2 diabetes mellitus (T2DM) and relates with disturbed glucagon suppression response in male patients

Cited by 4 publications

References 48 publications

The association between serum copper concentration and prevalence of diabetes among US adults with hypertension (NHANES 2011–2016)

The association between serum copper concentration and prevalence of diabetes among US adults with hypertension (NHANES 2011–2016)

Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score

The Relationship between Levels of Zinc and Copper and Insulin Resistance in Polycystic Ovary Syndrome Patients in Homs

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