Lower skeletal muscle mass is associated with diabetes and insulin resistance: A cross‐sectional study

Park, Jin Hun; Lee, Mi Yeon; Shin, Hocheol; Yoon, Kyung Jae; Lee, JunYeop; Park, Jai Hyung

doi:10.1002/dmrr.3681

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…Usually, greater muscle mass is associated with greater insulin sensitivity. Park et al[ 5 ] reported that lower skeletal muscle mass is associated with greater insulin resistance. However, previous studies have shown that a greater muscle mass index is associated with greater insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Accompanying islet α- and β-cell dysregulation in T2D at the microscopic scale, alterations in body composition may take part in the processes of T2D at the macroscopic scale. Body composition alterations in T2D patients are characterized by increases in whole-body fat mass, ectopic fat deposition (visceral fat accumulation), and a decrease in skeletal muscle mass [ 5 , 6 ]. Is there any relationship between the macroscale of body composition and the microscale of α- and β-cell dysfunctions in the background of T2D?…”

Section: Introductionmentioning

confidence: 99%

“…Data from NHANES 1999 to 2004 (6147 men and 6369 women) revealed a positive correlation between DXA-measured metrics of adiposity (trunk fat mass, subtotal fat mass and total fat mass) and HOMA-IR (insulin resistance) and HOMA-β (β-cell function) [ 8 ]. A Korean study by Park et al [ 5 ] revealed that lower skeletal muscle mass was associated with insulin resistance and diabetes. Anoop et al [ 9 ] reported that elevated fasting plasma glucagon levels were positively associated with subcutaneous abdominal adipose tissue in 81 nonobese patients with T2D, but they failed to be associated with measures of lean muscle mass.…”

Section: Introductionmentioning

confidence: 99%

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Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes

Miao,

Xu,

Wang

et al. 2024

Diabetol Metab Syndr

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Background Accompanying islet α- and β-cell dysregulation in type 2 diabetes (T2D) at the microscopic scale, alterations in body composition at the macroscopic scale may affect the pathogenesis of T2D. However, the connections between body composition and islet α-cell and β-cell functions in T2D have not been thoroughly explored. Methods For this cross-sectional study, we recruited a total of 729 Chinese Han patients with T2D in a consecutive manner. Dual-energy X-ray absorptiometry (DXA) was used to measure body composition, which included total bone-free mass, total fat and lean mass, trunk fat and lean mass and limb fat and lean mass. Every patient underwent an oral glucose tolerance test to simultaneously detect glucose, C-peptide and glucagon. The indices of islet α-cell function included fasting glucagon levels and the area under the curve of glucagon after a challenge (AUCglucagon), while the indices of β-cell function included the insulin sensitivity index derived from C-peptide (ISIC-peptide) and the area under the curve of C-peptide after a challenge (AUCC-peptide). Results Among all patients, fat mass, especially trunk fat mass, was significantly correlated with ISIC-peptide and AUCC-peptide levels (r = − 0.330 and 0.317, respectively, p < 0.001), while lean mass, especially limb lean mass, was significantly correlated with fasting glucagon and AUCglucagon levels (r = − 0.196 and − 0.214, respectively, p < 0.001). Moreover, after adjusting for other relevant variables via multivariate linear regression analysis, increased trunk fat mass was independently associated with decreased ISIC-peptide (β = − 0.247, t = − 3.628, p < 0.001, partial R2 = 10.9%) and increased AUCC-peptide (β = 0.229, t = 3.581, p < 0.001, partial R2 = 8.2%), while decreased limb lean mass was independently associated with increased fasting glucagon (β = − 0.226, t = − 2.127, p = 0.034, partial R2 = 3.8%) and increased AUCglucagon (β = − 0.218, t = − 2.050, p = 0.041, partial R2 = 2.3%). Additionally, when separate analyses were performed with the same concept for both sexes, we found that increased trunk fat mass was still independently associated with decreased ISIC-peptide and increased AUCC-peptide, while decreased limb lean mass was still independently associated with increased fasting glucagon and AUCglucagon. Conclusions Increased trunk fat mass may partly account for decreased insulin sensitivity and increased insulin secretion, while decreased limb lean mass may be connected to increased fasting glucagon and postprandial glucagon secretion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes

Miao,

Xu,

Wang

et al. 2024

Diabetol Metab Syndr

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“…In individuals with obesity, it proves sufficiently reliable for estimating fat mass, exhibiting a strong correlation and minimal bias compared to DXA [ 27 ]. Two cross-sectional studies, involving over 400,000 Korean adults, employed BIA as a dependable option for measuring skeletal muscle, further affirming its reliability in the diverse populations [ 28 , 29 ]. In this study, VSR was computed as an indicator of MASLD risk by dividing the VFA (cm 2 ) by SMM (kg).…”

Section: Methodsmentioning

confidence: 99%

Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of metabolic dysfunction-associated steatotic liver disease in a Chinese population

Liu,

Li,

Sheng

et al. 2024

Lipids Health Dis

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Background The diagnosis and comprehension of nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) are gaining a better understanding. In this study, we examined the association between visceral fat area and skeletal muscle mass ratio (VSR) and the prevalence of MASLD in a Chinese population. Methods A cross-sectional study was conducted involving 10,916 individuals who underwent bioelectrical impedance analysis, along with anthropometric and biochemical measurements, from January 2022 to June 2023. According to the VSR distribution, sex-specific quartiles of VSR within the study population were defined. Linear trend tests were performed for the categorized VSR variables. Logistic regression models were performed to estimate the odds ratio and 95% confidence intervals between VSR distribution and MASLD prevalence stratified by sex. Results The prevalence of MASLD was 37.94% in the overall population (56.34% male), and it gradually increased with higher VSR levels in both genders (P < 0.001). Logistic regression analysis demonstrated a significant association between VSR and MASLD prevalence after adjusting for confounders. The odds ratio (95% confidence interval) for MASLD, comparing the lowest to the highest VSR quartile, was 3.159 (2.671, 3.736) for men and 2.230 (1.764, 2.819) for women (all P < 0.001). Restricted cubic splines also indicated significant non-linear relationships between VSR and MASLD prevalence. Conclusions VSR is positively associated with the prevalence of MASLD in this Chinese population, with a notably higher risk for men as VSR increases compared to women.

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“… 3 Previous studies have shown that it is associated with increased secretion of inflammatory cytokines and insulin resistance. 5 Therefore, reduced skeletal muscle mass disturbs normal glucose metabolism and affects insulin sensitivity and blood sugar levels. Sarcopenia is considered to be a novel complication observed in the middle-aged and elderly population with T2DM and has received increasing attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

Importance of Assessing Sarcopenia in Patients with Type 2 Diabetes Mellitus Based on Body Fat Percentage Measured by Dual-Energy X-Ray Absorptiometry in Different Genders

Hou,

Wei,

Yang

et al. 2024

DMSO

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Lower skeletal muscle mass is associated with diabetes and insulin resistance: A cross‐sectional study

Cited by 13 publications

References 34 publications

Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes

Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes

Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of metabolic dysfunction-associated steatotic liver disease in a Chinese population

Importance of Assessing Sarcopenia in Patients with Type 2 Diabetes Mellitus Based on Body Fat Percentage Measured by Dual-Energy X-Ray Absorptiometry in Different Genders

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