Lower thresholds for lifetime health effects in mammals from high-LET radiation – Comparison with chronic low-LET radiation

Сазыкина, Т. Г.; Крышев, А. И.

doi:10.1016/j.jenvrad.2016.10.013

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…This effort highlighted the challenge of taking a large population of available animal data and carefully extracting experiments that met strict inclusion criteria. Work on data from internal alpha-emitter experiments in both mice and dogs stored in the International Radiobiological Archive has shown the utility of comparing data that are not conducted under the same conditions (Sazykina and Kryshev, 2016). The use of stored data in these studies rather than new experiments on stored specimens is a sign of the additional challenges posed by molecular investigations in archival samples from radiobiological archives conducted many decades earlier (Tapio and Atkinson 2006;Tapio et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data

Morioka

Blyth

Imaoka

et al. 2019

International Journal of Radiation Biology

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Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses for life shortening and cancer prevalence using laboratory animals. Genetic and epigenetic alterations in radiation-induced tumors have been also analyzed, with the aim of better understanding mechanisms of radiation carcinogenesis. As well as the economic and practical limitations of repeating such large-scale experiments, ethical considerations make it vital that we store and share the pathological data and samples of the animal experiments for future use. We are now constructing such an archive called the Japan-Storehouse of Animal Radiobiology Experiments (J-SHARE).Methods: J-SHARE records include information such as detailed experimental protocols, necropsy records and photographs of organs at necropsy. For each animal organs and tumor tissues are dissected, and parts are stored as frozen samples at -80 ˚C. Samples fixed with formalin are also embedded in paraffin blocks for histopathological analyses.Digital copies of stained tissues are being systematically saved using a virtual slide system linked to original records by barcodes. Embedded and frozen tissues are available for molecular analysis. Conclusion:Similar archive systems for radiation biology have been also under construction in the USA and Europe,

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Section: Introductionmentioning

confidence: 99%

Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data

Morioka

Blyth

Imaoka

et al. 2019

International Journal of Radiation Biology

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show abstract

“…The reported findings range from claims of beneficial hormetic effects and adaptive responses to claims of low-dose hypersensitivity, bystander effect and genomic instability increasing the relative effects of low doses [18,19]. Specific studies are detailed in the European Radiobiological Archives (https://era.bfs.de), and in an article on the quantification of thresholds for lifetime health effects in wildlife [20].…”

Section: Review Of Radiation Effect Data For Wildlifementioning

confidence: 99%

Towards an ecological modelling approach for assessing ionizing radiation impact on wildlife populations

Batlle¹,

Biermans²,

Copplestone³

et al. 2022

J. Radiol. Prot.

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The emphasis of the international system of radiological protection of the environment is to protect populations of flora and fauna. Throughout the MODARIA programmes, the United Nations’ International Atomic Energy Agency (IAEA) has facilitated knowledge sharing, data gathering and model development on the effect of radiation on wildlife. We present a summary of the achievements of MODARIA I and II on wildlife dose effect modelling, extending to a new sensitivity analysis and model development to incorporate other stressors. We reviewed evidence on historical doses and transgenerational effects on wildlife from radioactively contaminated areas. We also evaluated chemical population modelling approaches, discussing similarities and differences between chemical and radiological impact assessment in wildlife. We developed population modelling methodologies by sourcing life history and radiosensitivity data and evaluating the available models, leading to the formulation of an ecosystem-based mathematical approach. This resulted in an ecologically relevant conceptual population model, which we used to produce advice on the evaluation of risk criteria used in the radiological protection of the environment and a proposed modelling extension for chemicals. This work seeks to inform stakeholder dialogue on factors influencing wildlife population responses to radiation, including discussions on the ecological relevance of current environmental protection criteria. The area of assessment of radiation effects in wildlife is still developing with underlying data and models continuing to be improved. IAEA’s ongoing support to facilitate the sharing of new knowledge, models and approaches to Member States is highlighted, and we give suggestions for future developments in this regard.

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Influence of chronic low-dose/dose-rate high-LET irradiation from radium-226 in a human colorectal carcinoma cell line

Sokeechand

Seymour

et al. 2017

Environmental Research

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Lower thresholds for lifetime health effects in mammals from high-LET radiation – Comparison with chronic low-LET radiation

Cited by 5 publications

References 38 publications

Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data

Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data

Towards an ecological modelling approach for assessing ionizing radiation impact on wildlife populations

Influence of chronic low-dose/dose-rate high-LET irradiation from radium-226 in a human colorectal carcinoma cell line

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