Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia Patients: Orchestrated by Chronic Prostatic Inflammation and Prostatic Calculi?

Abstract

Objective: This study aims to examine the relationship between chronic prostatic inflammation and prostatic calculi, and clinical parameters of benign prostatic hyperplasia (BPH). Materials and Methods: This study was based on 225 patients who underwent transurethral resection of the prostate for BPH. Chronic inflammation was graded as 0 (n = 44), I (n = 54), II (n = 88) or III (n = 39) according to severity. Prostatic calculi were classified into types A (n = 66), B (n = 44), M (n = 77) and N (n = 38). The relationship between inflammation and calculus type was analyzed, and clinical parameters of BPH were compared for each group. Results: There was no correlation between severity of inflammation and calculus type. Prostatic volume increased with the severity of inflammation and showed significant differences between G2, G3 and G0. The International Prostate Symptom Score also increased with increasing inflammation. There was no significant difference between each clinical parameter according to calculus type. Conclusions: Prostatic calculi had no significant association with chronic inflamma- tion and clinical parameters of BPH. Chronic inflammation was associated with the volume of the prostate and storage symptoms; thus, it is not only presumed to be related to the progression of BPH, but may also be one of the causes of lower urinary tract symptoms.

Is There A Relation Between Serum Uric Acid Values and Prostatic Calculi Presence?

“…Previous studies have reported that there may be a relationship between an increase in prostate volume and the incidence of PCal [19,20]. In our study, the PCal+ group had a higher prostate volume than the PCal-group, but this difference was not significant (51.63 vs .50.85, p = 0.7).…”

Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study

“…However, there is increasing evidence linking histologic prostate inflammation with benign prostate hyperplasia (BPH) and degree of lower urinary tract symptoms (28,29). For example, a previous study using data from the REDUCE trial found significant correlation between chronic inflammation and urinary symptoms (17).…”

Is Periurethral Calcification Associated With Urinary Flow Rate and Symptom Severity in Men With Lower Urinary Tract Symptoms-Benign Prostatic Hyperplasia? A Retrospective Review

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