Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants

Çetınkaya, Merih; Çekmez, Ferhat; Büyükkale, Gökhan; Erener-Ercan, Tuğba; Demir, Ferhat; Tunç, Turan; Aydin, FN; Aydemir, Gökhan

doi:10.1038/jp.2014.146

Cited by 94 publications

(110 citation statements)

References 39 publications

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“…18,38,39 In a recent study of our group, we demonstrated that lower maternal and neonatal 25-OHD levels were associated with early-onset sepsis in term infants. 40 In a very recent study, VDR Fok 1 polymorphism was found to be associated with increased frequency of BPD. 41 Our study is the first in the literature to demonstrate a possible association between maternal/neonatal 25-OHD levels and BPD.…”

Section: Discussionmentioning

confidence: 98%

Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

et al. 2015

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Section: Discussionmentioning

confidence: 98%

Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

et al. 2015

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“…For the entire group of 50 infants with early-onset neonatal sepsis (EONS), the postpartum maternal and neonatal 25(OH)D levels were 56 nmol/l (SD = 17 nmol/l), compared with 91 nmol/l (SD = 5 nmol/l) and 45 nmol/l (SD = 12 nmol/l) respectively for the controls [Cetinkaya et al 2015a]. A second study in Turkey involving 40 neonates with EONS and 43 controls found that cord blood 25(OH)D levels were 32 nmol/l (8-197 nmol/l) for those with EONS and 53 nmol/l (13-295 nmol/l) for controls, p = 0.04 [Cizmeci et al 2015].…”

Section: Maternal Hypovitaminosis D Impact On Neonatal Infections Andmentioning

confidence: 99%

Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications

Karras

Fakhoury

Muscogiuri³

et al. 2016

Therapeutic Advances in Musculoskeletal

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Low maternal vitamin D levels during pregnancy have been associated with a plethora of adverse neonatal outcomes, including small for gestational age and preterm births, detrimental effect on offspring bone and teeth development, and risk of infectious diseases. Although most observational studies indicate a significant linear relationship between maternal 25-hydroxyvitamin D and the above outcomes, some randomized controlled trials to date are inconclusive, mostly due to differences in study design and supplementation regimen. The currently available results indicate that vitamin D supplementation during pregnancy reduces the risk of preterm birth, low birth weight, dental caries of infancy, and neonatal infectious diseases such as respiratory infections and sepsis. This narrative review aims to summarize available trial results regarding the effect of low maternal vitamin D levels during pregnancy, in conjunction with neonatal outcomes on the field, with a discourse on the appropriate clinical approach of this important issue.

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“…59,60 One of these studies only included patients with culture-proven sepsis, while the other did not find significant associations in the subset of cases with culture-proven sepsis. The Gad et al 61 study similarly found lower cord 25(OH)D levels in subjects with neonatal pneumonia compared with healthy controls.…”

Section: Infectious Diseasementioning

confidence: 99%

Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

et al. 2016

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Context: It is unclear how in utero vitamin D deficiency affects the extraskeletal health of children, despite the known risks for adverse pregnancy/birth outcomes. Objective: This systematic review seeks to assess the effect of in utero vitamin D exposure on childhood allergy and infection outcomes using the PRISMA guidelines. Data Sources: MEDLINE, Cochrane Library, and Web of Science databases were searched. Study Selection: Literature published through April 2015 was searched for studies reporting on the association between maternal pregnancy or cord blood vitamin D status and childhood allergy and infection. Data Extraction: Of 4175 articles identified, 43 studies met the inclusion criteria. They examined a wide variety of outcomes, using many different vitamin D cutoff values in their analyses. Data Synthesis: For most outcomes, results were inconsistent, although there appeared to be a protective effect between higher in utero vitamin D status and childhood lower respiratory tract infection (5 of 10 studies). Conclusions: More research is needed on childhood allergy and infection outcomes, and future studies should standardize outcome reporting, especially with regard to cutoff values for vitamin D concentrations. Evidence of a protective association between in utero vitamin D exposure and lower respiratory tract infection was found, while the other outcomes were either understudied or showed inconsistent results. PROSPERO registration no. CRD42013006156.

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Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants

Abstract: Lower maternal and neonatal 25-OHD levels are associated with EOS. These data suggest that adequate vitamin D supplementation during pregnancy may be helpful to prevent EOS in term neonates.

Cited by 94 publications

References 39 publications

Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications

Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

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