Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression

Vriese, S. R. De; Christophe, Armand; Maes, Michaël

doi:10.1016/j.lfs.2003.02.001

Cited by 177 publications

(110 citation statements)

References 24 publications

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“…(1998) (63) C major depression (64) C major depression (65) C major depression (66) C and SC major depression (67) C major depression in ACS patients (68) C major depression in ACS patients (69) C depression in MI patients (70) C postpartum (71) C major depression (72) C major depression (74) NC adolescent depression (75) NC depression in lung cancer patients…”

Section: Trial Evidencementioning

confidence: 99%

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

2008

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Selected biochemical evidence suggests a potential role for n-3 long-chain PUFA (n-3PUFA) in the regulation of mood and behaviour. The present paper reviews the relevant evidence, to date, from epidemiological studies, clinical studies and intervention trials. Most evidence is available investigating a role for n-3PUFA in depression, depressive illness and suicidal behaviour, but work is also available on anxiety and anxiety-related disorders, fatigue and fatigue-related disorders, aggression, hostility and anti-social behaviour, inattention, impulsivity and attention deficit hyperactivity disorder and schizophrenic disorders. For all these aspects of mood and behaviour, the evidence available is currently limited and highly inconsistent, both in terms of study methodology and study findings. There is a clear need for further work in this area.

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Section: Trial Evidencementioning

confidence: 99%

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

2008

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“…There is evidence for associations between poor LC n-3 PUFA status and postnatal depression, and for minor reductions in maternal brain size during, and for 6 months after, pregnancy (Oatridge et al 2002), perhaps indicating a temporary loss of maternal DHA. Useful evidence was provided by a prospective study which compared postpartum fatty acid profiles in women who did (n 10) and did not (n 38) develop postnatal depression (De Vriese et al 2003). The authors found that the n-6:n-3 ratio was higher in the depressed mothers, concluding that LC n-3 PUFA supplementation should be given to women at risk from postnatal depression.…”

Section: Schizophrenia a Cochrane Reviewmentioning

confidence: 99%

The impact of long-chainn-3 polyunsaturated fatty acids on human health

et al. 2005

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A considerable literature has been published on the health benefits of fish, oil-rich fish and fish oils and their constituent long-chain (LC)n-3 PUFA. Evidence from epidemiological studies highlights the cardioprotective attributes of diets rich in fish, especially oil-rich fish. Data from intervention trials are consistent in suggesting that LCn-3 PUFA lower the risk of CVD, probably by the multiple mechanisms of lowering serum triacylglycerols, improving the LDL:HDL ratio, anti-arrhythmic effects on heart muscle, improved plaque stability, anti-thrombotic effects and reduced endothelial activation. Research indicates LCn-3 PUFA provision has an impact during development, and there is preliminary evidence that docosahexaenoic acid supplementation during pregnancy could optimise brain and retina development in the infant. LCn-3 PUFA are also postulated to ameliorate behavioural and mental health disturbances such as depression, schizophrenia, dementia and attention deficit hyperactivity disorder. However, despite some positive evidence in each of these areas, use of LCn-3 PUFA in these conditions remains at the experimental stage. In the case of immune function, there is little doubt that LCn-3 PUFA have a positive effect. Although intervention trials in rheumatoid arthritis show strong evidence of benefit, evidence for efficacy in other inflammatory conditions, including Crohn's disease, ulcerative colitis, psoriasis, lupus, multiple sclerosis, cystic fibrosis and asthma, is inconsistent or inadequate. More promising evidence in some conditions may come from studies which attempt to modify the fetal environment using LCn-3 PUFA supplementation during pregnancy.

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“…Of the former, six were randomized controlled trials (Doornbos et al, 2009;Freeman et al, 2008;Llorent et al, 2003;Makrides et al, 2010;Mozurkewich et al, 2013;Rees, Austin, & Parker, 2008) and two pilot trials (Freeman et al, 2006;Marangell et al, 2004). The nine observational studies included: one ecological study (Hibbeln, 2002), a cross-sectional study (De Vriese, Christophe, & Maes, 2003), a case-control study (Browne, Scott, & Silvers, 2006), and six cohort studies (da Rocha & Kac, 2012;Markhus et al, 2013;Miyake et al, 2006;Otto, De Groot, & Hornstra, 2003;Parker et al, 2014;Strøm, Mortensen, Halldorsson, Thorsdottir, & Olsen, 2009). The included studies and the results of our quality appraisals are summarized in Table A1, while more detail on the characteristics of the studies is presented in Table A2.…”

Section: Overall Results In Context With Expectations Arising From Thmentioning

confidence: 99%

Role of Omega-3 Unsaturated Fatty Acids in the Postpartum Depression: Systematic Review and Narrative Synthesis

Mougharbel¹,

Deonandan²

2016

GJHS

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Background: Postpartum depression (PPD) is a complex mental health disorder that affects women during their childbearing years. It is a serious medical condition that occurs in approximately 15% of women after birth and has an adverse effect on both the mother and the infant. Hypotheses exist relating dietary deficiencies in a pregnant or postnatal woman's diet may cause postnatal depression. It is unclear whether Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are effective for treating or preventing PPD. Objectives:To assess the best available evidence to date regarding the effect of n-3 PUFAs on the etiology, prevention and treatment of postnatal depression. Methods:A systematic review and narrative synthesis was conducted in order to address the gaps in knowledge. For the systematic review, a broad search of electronic databases of published quantitative literature was conducted. The narrative synthesis consists of four elements: 1) developing a theory; 2) developing a preliminary synthesis; 3) exploring relationships in the data; 4) assessing the robustness of the synthesis. Published experimental and observational studies were accepted involving women who were pregnant or who had given birth in the previous six weeks. N-3 PUFAs was the intervention of interest and PPD was the outcome.Results: Out of 181 potential articles, a total of 17 studies met the inclusion criteria. The overwhelming majority of the studies found that n-3 PUFAs had no inverse association with PPD evaluations. Significant heterogeneity was observed among included studies. Conclusions:Overall, This systematic review and narrative synthesis failed to find a significant positive association between n-3 PUFAs intake and PPD.

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Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression

Cited by 177 publications

References 24 publications

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

The impact of long-chainn-3 polyunsaturated fatty acids on human health

Role of Omega-3 Unsaturated Fatty Acids in the Postpartum Depression: Systematic Review and Narrative Synthesis

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