Lowering of body temperature affects human platelet functions and norepinephrine release

Opper, C.; Hennig, Jürgen; Clement, Cristina C.; Laschefski, U; Dey, Daniela; Dieckwisch, Jutta; Netter, Petra; Wesemann, W.

doi:10.1016/0091-3057(94)00432-i

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…29 A mobilisation of granulocytes has been observed,30 and red cell counts and plasma cholesterol and fibrinogen concentrations, all of which may be thrombogenic, seem to be raised after exposure to cold 2831 Finally, one study has suggested that the density distribution of blood platelet subpopulations may be affected, with an observed increase in less dense platelets that were more sensitive towards agents that induce aggregation 32. These small experimental studies combine to suggest that a pathway for cold induced thrombogenesis might involve a combination of factors, including haemoconcentration, an inflammatory response, and a tendency for an increased state of hypercoagulability.…”

Section: Discussionmentioning

confidence: 99%

Short term effects of temperature on risk of myocardial infarction in England and Wales: time series regression analysis of the Myocardial Ischaemia National Audit Project (MINAP) registry

Bhaskaran

Hajat

Haines

et al. 2010

BMJ

195

166

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Objective To examine the short term relation between ambient temperature and risk of myocardial infarction. Design Daily time series regression analysis. Setting 15 conurbations in England and Wales. Participants 84 010 hospital admissions for myocardial infarction recorded in the Myocardial Ischaemia National Audit Project during 2003-6 (median 57 events a day). Main outcome measures Change in risk of myocardial infarction associated with a 1°C difference in temperature, including effects delayed by up to 28 days. Results Smoothed graphs revealed a broadly linear relation between temperature and myocardial infarction, which was well characterised by log-linear models without a temperature threshold: each 1°C reduction in daily mean temperature was associated with a 2.0% (95% confidence interval 1.1% to 2.9%) cumulative increase in risk of myocardial infarction over the current and following 28 days, the strongest effects being estimated at intermediate lags of 2-7 and 8-14 days: increase per 1°C reduction 0.6% (95% confidence interval 0.2% to 1.1%) and 0.7% (0.3% to 1.1%), respectively. Heat had no detrimental effect. Adults aged 75-84 and those with previous coronary heart disease seemed more vulnerable to the effects of cold than other age groups (P for interaction 0.001 or less in each case), whereas those taking aspirin were less vulnerable (P for interaction 0.007). Conclusions Increases in risk of myocardial infarction at colder ambient temperatures may be one driver of cold related increases in overall mortality, but an increased risk of myocardial infarction at higher temperatures was not detected. The risk of myocardial infarction in vulnerable people might be reduced by the provision of targeted advice or other interventions, triggered by forecasts of lower temperature. INTRODUCTIONIn the light of global climate change the relations between weather and health are of increasing interest.

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Section: Discussionmentioning

confidence: 99%

Short term effects of temperature on risk of myocardial infarction in England and Wales: time series regression analysis of the Myocardial Ischaemia National Audit Project (MINAP) registry

Bhaskaran

Hajat

Haines

et al. 2010

BMJ

195

166

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“… 20 Cold exposure has been shown to increase plasma catecholamine concentration. 21 , 22 , 23 , 24 , 25 As a result of splenic constriction induced by plasma catecholamine, 26 pooled thrombocytes in the spleen are released into the blood stream, leading to increased PLT count. 27 , 28 Although the plasma catecholamine has a short half-life and disappears quickly (within 30 min), a part of the plasma catecholamine is taken up by the PLTs 29 , 30 and demonstrates a relatively long-term effect.…”

Section: Discussionmentioning

confidence: 99%

Platelet count and indoor cold exposure among elderly people: A cross-sectional analysis of the HEIJO-KYO study

Saeki

Obayashi

Kurumatani

2017

Journal of Epidemiology

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BackgroundExcess mortality from cardiovascular disease during cold seasons is a worldwide issue. Although some physiologic studies suggests that platelet activation via cold exposure may cause an increased incidence of cardiovascular disease in winter, the influence of indoor cold exposure in real-life situations on platelet (PLT) count remains unclear.MethodsA cross-sectional study was conducted among 1095 elderly individuals. After obtaining a venous sample in the morning, indoor temperature of participants' home was measured every 10 min for 48 h. The mean indoor temperature while the participants stayed at home was calculated. All measurement was conducted during cold seasons (October to April) from 2010 to 2014.ResultsThe mean age of the 1095 participants was 71.9 years. They spent 87.3% of the day at home (20 h 27 min). A 1 °C lower daytime indoor temperature was associated with a significant increase in PLT count of 1.47 × 109/L (95% confidence interval, 0.39–2.56 × 109/L). Compared with the warmest tertile group (20.1 [standard deviation {SD}, 0.09] °C), the coldest group (11.7 [SD, 0.12] °C) showed a 5.2% higher PLT count (238.84 [SD, 3.30] vs. 226.48 [SD, 3.32] × 109/L; P = 0.01), even after adjusting for basic characteristics (age, gender, body weight, and smoking), antihypertensive medication, comorbidities (diabetes, estimated glomerular filtration rate), socioeconomic status (household income and education), day length, and outdoor temperature.ConclusionsWe found a significant and independent association between lower indoor temperature and higher PLT count among elderly in winter.

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“…Commercial climate (or environmental) chambers that monitor and control temperature and humidity levels are available in various forms and sizes, but many researchers have chosen to develop their own climate chambers in order to fit their research objectives. Commercial and custom-made climate chambers, incubators and bioreactors have been used in studies with cell cultures [2,15,16], animal models [4,8,10], and human subjects [3,9,[11][12][13][14]. In the following sections we describe a new desktop climate chamber that was developed for application of respiratory airflows on cultured nasal epithelial cells (NEC) under controlled temperature and humidity conditions.…”

Section: Introductionmentioning

confidence: 99%

Climate chamber for environmentally controlled laboratory airflow experiments

Even-Tzur

Zaretsky

Grinberg

et al. 2010

THC

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Climate chambers have been widely used in in vitro and in vivo studies which require controlled environmental temperature and humidity conditions. This article describes a new desktop climate chamber that was developed for application of respiratory airflows on cultured nasal epithelial cells (NEC) under controlled temperature and humidity conditions. Flow experiments were performed by connecting the climate chamber to an airflow generator via a flow chamber with cultured NEC. Experiments at two controlled climate conditions, 25 • C and 40% relative humidity (RH) and 37 • C and 80%RH, were conducted to study mucin secretion from the cultures in response to the flow. The new climate chamber is a relatively simple and inexpensive apparatus which can easily be connected to any flow system for climate controlled flow experiments. This chamber can be easily adjusted to various in vitro experiments, as well as to clinical studies with animals or human subjects which require controlled climate conditions.

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Lowering of body temperature affects human platelet functions and norepinephrine release

Cited by 13 publications

References 22 publications

Short term effects of temperature on risk of myocardial infarction in England and Wales: time series regression analysis of the Myocardial Ischaemia National Audit Project (MINAP) registry

Short term effects of temperature on risk of myocardial infarction in England and Wales: time series regression analysis of the Myocardial Ischaemia National Audit Project (MINAP) registry

Platelet count and indoor cold exposure among elderly people: A cross-sectional analysis of the HEIJO-KYO study

Climate chamber for environmentally controlled laboratory airflow experiments

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